FISH MYCN Amplification Test: Advanced Neuroblastoma Genetic Analysis
Understanding the FISH MYCN Amplification Test
The FISH MYCN Amplification Test represents a critical advancement in cancer diagnostics, specifically designed to detect genetic abnormalities associated with neuroblastoma. This sophisticated molecular test utilizes Fluorescence In Situ Hybridization (FISH) technology to identify amplification of the MYCN oncogene, which plays a pivotal role in neuroblastoma pathogenesis and progression. Neuroblastoma, a common childhood cancer originating from neural crest cells, demonstrates variable clinical behavior largely influenced by MYCN amplification status.
What Does the Test Measure?
The FISH MYCN Amplification Test specifically detects:
- MYCN gene amplification status in tumor cells
- Copy number variations of the MYCN oncogene
- Genetic markers associated with aggressive neuroblastoma behavior
- Chromosomal abnormalities at the 2p24 locus
Who Should Consider This Test?
This test is essential for patients presenting with:
- Newly diagnosed neuroblastoma cases requiring comprehensive staging
- Children with abdominal masses or adrenal tumors
- Patients with suspected high-risk neuroblastoma features
- Cases requiring treatment intensity stratification
- Patients with recurrent or progressive neuroblastoma
- Individuals with family history of neuroblastoma or genetic predisposition
Clinical Symptoms and Indications
Patients exhibiting symptoms such as abdominal swelling, bone pain, unexplained fever, weight loss, or neurological symptoms should be evaluated for neuroblastoma. The FISH MYCN Amplification Test becomes crucial when:
- Initial biopsy confirms neuroblastoma diagnosis
- Treatment planning requires risk stratification
- Prognostic assessment is needed for clinical trial eligibility
- Monitoring treatment response in high-risk cases
Benefits of Taking the FISH MYCN Amplification Test
This comprehensive genetic analysis offers numerous advantages:
- Accurate Prognostic Assessment: MYCN amplification status directly correlates with disease aggressiveness and survival outcomes
- Personalized Treatment Planning: Results guide chemotherapy intensity and treatment duration decisions
- Risk Stratification: Helps classify patients into appropriate risk groups for tailored therapy
- Clinical Trial Eligibility: Essential for enrollment in specific neuroblastoma treatment protocols
- Family Counseling: Provides valuable information for genetic counseling in familial cases
Understanding Your Test Results
Your FISH MYCN Amplification Test results will provide critical information:
- MYCN Amplification Positive: Indicates high-risk neuroblastoma requiring intensive treatment protocols
- MYCN Amplification Negative: Suggests standard or intermediate-risk disease with potentially less aggressive therapy
- Borderline Results: May require additional testing or clinical correlation
- Technical Limitations: Results interpretation considers sample quality and tumor content
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| FISH MYCN Amplification Test | $300 USD | $450 USD |
Turnaround Time and Sample Requirements
Turnaround: Samples accepted daily by 4 PM; Reports delivered within 4 working days
Sample Type: Submit formalin-fixed paraffin-embedded tissue block containing minimum 10% tumor tissue
Shipping: Ship at room temperature with completed Chromosome & FISH Analysis Requisition Form (Form 17)
Nationwide Availability Across USA
We proudly serve patients across the United States with convenient testing locations in:
- New York City and surrounding areas
- Los Angeles and Southern California
- Chicago and Midwest regions
- Houston and Texas metropolitan areas
- Phoenix and Southwest territories
- All major cities and regional centers
Book Your Test Today
Take the first step toward comprehensive neuroblastoma management. Our experienced oncology team and advanced cytogenetics laboratory ensure accurate, reliable results you can trust for critical treatment decisions.
Call or WhatsApp: +1(267) 388-9828 to schedule your FISH MYCN Amplification Test or to speak with our genetic counseling specialists.
Our dedicated patient coordinators are available to assist with insurance verification, sample collection coordination, and result interpretation. Trust General Genetics Corporation for precision oncology testing that makes a difference in patient outcomes.
