FISH inv16 or LSI CBFB Test – Advanced Leukemia Genetic Analysis
Understanding the FISH inv16 or LSI CBFB Test
The FISH inv16 or LSI CBFB Test represents a cutting-edge molecular diagnostic approach for detecting specific chromosomal abnormalities in leukemia patients. This sophisticated fluorescence in situ hybridization (FISH) technique targets the inversion 16 abnormality involving the CBFB (Core Binding Factor Beta) gene, which plays a critical role in normal blood cell development and differentiation.
When the CBFB gene becomes disrupted through chromosomal inversion, it creates fusion genes that interfere with normal cellular processes, leading to uncontrolled cell growth characteristic of acute myeloid leukemia (AML). The precision of this test allows for early detection and accurate classification of leukemia subtypes, enabling healthcare providers to implement targeted treatment strategies that significantly improve patient outcomes.
What the Test Measures and Detects
The FISH inv16 or LSI CBFB Test specifically identifies:
- Inversion 16 chromosomal abnormalities involving the CBFB gene
- Presence of CBFB-MYH11 fusion genes
- Chromosomal rearrangements at chromosome 16p13
- Genetic markers associated with core-binding factor acute myeloid leukemia
- Specific molecular signatures that predict treatment response
This advanced genetic analysis provides crucial information about the underlying genetic architecture of leukemia cells, helping oncologists understand the disease at a molecular level and make informed decisions about therapeutic interventions.
Who Should Consider This Test
This specialized genetic test is recommended for individuals experiencing:
- Unexplained fatigue, weakness, or persistent tiredness
- Frequent infections or unusual susceptibility to illness
- Unexplained bruising, bleeding, or petechiae
- Bone pain or tenderness
- Enlarged lymph nodes, liver, or spleen
- Unexplained weight loss or night sweats
- Abnormal blood counts detected during routine examinations
- Suspected or newly diagnosed acute myeloid leukemia
- Monitoring treatment response in known AML cases
Clinical Indications Include:
- Patients with suspected acute myeloid leukemia
- Individuals with abnormal bone marrow findings
- Patients requiring accurate leukemia subtype classification
- Cases where treatment planning depends on genetic markers
- Monitoring minimal residual disease after treatment
Benefits of Taking the FISH inv16 or LSI CBFB Test
Choosing this advanced genetic analysis provides numerous clinical advantages:
- Accurate Diagnosis: Provides definitive identification of specific leukemia subtypes
- Personalized Treatment: Enables targeted therapy selection based on genetic markers
- Prognostic Information: Helps predict disease course and treatment response
- Treatment Monitoring: Allows tracking of treatment effectiveness over time
- Early Detection: Identifies genetic abnormalities before clinical symptoms worsen
- Comprehensive Analysis: Offers detailed genetic profiling for informed decision-making
- Rapid Results: Provides critical information within 4 working days
Understanding Your Test Results
Your FISH inv16 or LSI CBFB Test results will provide valuable insights into your genetic profile:
Positive Results:
A positive result indicates the presence of inversion 16 abnormalities involving the CBFB gene. This finding typically confirms a diagnosis of core-binding factor acute myeloid leukemia, which generally has a favorable prognosis with appropriate treatment. Your oncologist will use this information to develop a targeted treatment plan that may include specific chemotherapy regimens.
Negative Results:
A negative result means no inversion 16 abnormalities were detected. This helps exclude certain leukemia subtypes and may guide your healthcare provider toward alternative diagnostic considerations or different treatment approaches. Negative results are equally valuable for comprehensive disease characterization.
Interpretation Guidance:
- Results should always be interpreted by qualified hematologists or oncologists
- Genetic findings must be considered alongside clinical symptoms and other laboratory results
- Regular follow-up testing may be recommended for monitoring purposes
- Results contribute to ongoing treatment adjustments and long-term care planning
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| FISH inv16 or LSI CBFB Test | $150 USD | $212 USD |
Turnaround Time and Sample Requirements
Turnaround: Samples accepted daily by 4 PM | Results delivered in 4 working days
Sample Type: 5 mL (3 mL minimum) whole blood OR 4 mL (2 mL minimum) Bone Marrow from 2 Green Top (Sodium Heparin) tubes
Shipping: Ship at 18-22°C | DO NOT FREEZE
Required Documentation: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory
Nationwide Availability Across USA
GGC DNA maintains comprehensive testing facilities across all major United States metropolitan areas, including:
- New York City and surrounding tri-state area
- Los Angeles and Southern California region
- Chicago and greater Illinois territory
- Houston and Texas Gulf Coast locations
- Phoenix and Arizona metropolitan centers
- Philadelphia, Miami, Atlanta, and other key cities
Our nationwide network ensures convenient access to advanced genetic testing services regardless of your location. Each facility maintains the same high standards of quality, accuracy, and professional service that define the GGC DNA commitment to excellence in patient care.
Take Action Today – Book Your Test
Don’t delay in obtaining the critical genetic information you need for informed healthcare decisions. Our team of genetic specialists and oncology consultants are ready to assist you with:
- Comprehensive test explanations and clinical guidance
- Convenient appointment scheduling at locations near you
- Professional sample collection and handling
- Clear result interpretation and follow-up recommendations
- Coordination with your healthcare providers
Call us today at +1(267) 388-9828 to schedule your FISH inv16 or LSI CBFB Test. Our genetic counseling team is available to answer your questions, discuss testing options, and help you understand how this advanced genetic analysis can contribute to your personalized healthcare strategy.
Take the first step toward comprehensive genetic understanding and targeted treatment planning. Contact GGC DNA now and benefit from our expertise in cancer cytogenetics and molecular diagnostics.
