FISH 1p 19q Codeletion Test: Advanced Genetic Analysis for Brain Tumor Diagnosis
Understanding the FISH 1p 19q Codeletion Test
The FISH 1p 19q Codeletion Test represents a breakthrough in molecular diagnostics for brain tumor classification and treatment planning. This sophisticated genetic analysis utilizes Fluorescence In Situ Hybridization (FISH) technology to detect specific chromosomal abnormalities that are critical for accurate diagnosis and prognosis in neuro-oncology.
This test specifically examines the simultaneous deletion of genetic material from the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q). The presence of this combined deletion serves as a definitive molecular marker that distinguishes oligodendrogliomas from other types of brain tumors, enabling more precise treatment decisions and improved patient outcomes.
What the Test Measures and Detects
The FISH 1p 19q Codeletion Test provides comprehensive analysis of specific chromosomal regions:
- Chromosome 1p Deletion Detection: Identifies loss of genetic material from the short arm of chromosome 1
- Chromosome 19q Deletion Detection: Detects loss from the long arm of chromosome 19
- Codeletion Status: Determines whether both deletions are present simultaneously
- Tumor Classification: Helps differentiate oligodendrogliomas from astrocytomas and other glioma subtypes
Technical Methodology
Using advanced FISH technology, the test employs fluorescent DNA probes that bind specifically to the 1p and 19q chromosomal regions. When these regions are deleted, the fluorescent signals are reduced or absent, providing visual confirmation of the genetic abnormality under specialized microscopy.
Who Should Consider This Test
This genetic test is recommended for patients with:
- Suspected or confirmed brain tumors on imaging studies
- Clinical symptoms including persistent headaches, seizures, neurological deficits, or cognitive changes
- MRI findings suggestive of oligodendroglioma or mixed glioma
- Previous inconclusive biopsy results requiring molecular confirmation
- Need for treatment planning and prognosis determination
- Family history of brain tumors or genetic syndromes
Symptoms and Clinical Indications
Patients experiencing any of the following symptoms should discuss this test with their healthcare provider:
- Unexplained headaches that worsen over time
- New-onset seizures or changes in seizure patterns
- Progressive weakness or numbness in limbs
- Speech difficulties or language problems
- Vision changes or visual disturbances
- Personality changes or cognitive decline
- Balance problems or coordination difficulties
Benefits of Taking the FISH 1p 19q Codeletion Test
This advanced genetic testing offers numerous advantages for patients and healthcare providers:
Diagnostic Precision
- Provides definitive molecular classification of brain tumors
- Differentiates oligodendrogliomas from other glioma subtypes
- Reduces diagnostic uncertainty and misclassification
- Supports World Health Organization (WHO) tumor grading criteria
Treatment Guidance
- Predicts response to chemotherapy and radiation therapy
- Helps determine optimal treatment combinations
- Guides decisions about surgical intervention extent
- Supports personalized medicine approaches
Prognostic Information
- Provides valuable information about expected treatment outcomes
- Helps predict tumor behavior and progression patterns
- Supports long-term treatment planning and monitoring strategies
- Enables more accurate patient counseling and expectation setting
Understanding Your Test Results
Your FISH 1p 19q Codeletion Test results will fall into one of several categories, each with specific clinical implications:
Positive for 1p/19q Codeletion
A positive result indicates the presence of combined 1p and 19q deletions, which strongly supports a diagnosis of oligodendroglioma. Patients with this result typically demonstrate:
- Better response to chemotherapy, particularly PCV (procarbazine, lomustine, vincristine) regimen
- Improved overall survival compared to non-codeleted tumors
- Longer progression-free survival periods
- Potential eligibility for specific clinical trials
Negative for 1p/19q Codeletion
A negative result suggests the absence of the characteristic codeletion pattern, which may indicate:
- Diagnosis of astrocytoma or other glioma subtypes
- Different treatment response patterns
- Alternative molecular testing recommendations
- Consideration of additional diagnostic procedures
Inconclusive Results
In some cases, technical factors or sample quality may lead to inconclusive results, requiring:
- Repeat testing with additional tissue samples
- Alternative molecular testing methods
- Correlation with clinical and radiological findings
- Consultation with neuropathology specialists
Test Information and Pricing
| Test Parameter | Details |
|---|---|
| Test Name | FISH 1p 19q Codeletion Test |
| Discount Price | $300 USD |
| Regular Price | $450 USD |
| Turnaround Time | 1 Week |
| Sample Type | Formalin fixed paraffin embedded tissue block with 10% tumor tissue |
| Shipping Requirements | Room temperature with completed Form 17 |
Nationwide Availability and Booking
GGC DNA maintains comprehensive testing facilities across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures accessible, reliable genetic testing services for patients nationwide.
How to Prepare for Your Test
Proper preparation ensures accurate and reliable results:
- Consult with your healthcare provider to determine test necessity
- Ensure tissue sample meets technical requirements (10% tumor content)
- Complete the mandatory Chromosome & FISH analysis Requisition Form (Form 17)
- Coordinate sample collection and shipping with your medical facility
- Discuss insurance coverage and payment options in advance
Take Control of Your Brain Health Today
Don’t let uncertainty about your brain tumor diagnosis delay your treatment journey. The FISH 1p 19q Codeletion Test provides the critical genetic information needed for accurate diagnosis and personalized treatment planning. Our team of genetic specialists and oncology experts are ready to support you through every step of the testing process.
Call us now at +1(267) 388-9828 to schedule your FISH 1p 19q Codeletion Test or to speak with our genetic counseling team. Take the first step toward precise diagnosis and optimal treatment outcomes today.
Our commitment to excellence in genetic testing ensures you receive the highest quality analysis, comprehensive reporting, and personalized support throughout your diagnostic journey. Trust GGC DNA for accurate, reliable genetic testing that makes a difference in your brain tumor management.
