FISH 17p TP53 Deletion Test
Understanding the FISH 17p TP53 Deletion Test
The FISH 17p TP53 Deletion Test represents a cutting-edge diagnostic approach in cancer genetics, specifically designed to detect critical chromosomal abnormalities in Multiple Myeloma patients. This sophisticated test utilizes Fluorescence In Situ Hybridization (FISH) technology to examine chromosome 17p, where the vital TP53 tumor suppressor gene resides. The TP53 gene plays a crucial role in preventing cancer development by regulating cell division and triggering programmed cell death in damaged cells. When deletions occur in this region, cancer cells can proliferate uncontrollably, leading to more aggressive disease progression and treatment resistance.
What Does This Test Measure?
The FISH 17p TP53 Deletion Test specifically detects:
- Deletions of the TP53 tumor suppressor gene on chromosome 17p
- Genetic abnormalities that indicate high-risk Multiple Myeloma
- Chromosomal changes affecting treatment response and prognosis
- Specific genetic markers that guide personalized therapy selection
Who Should Consider This Test?
This test is particularly important for individuals with:
- Newly diagnosed Multiple Myeloma requiring risk stratification
- Relapsed or refractory Multiple Myeloma cases
- Patients with aggressive disease presentation or rapid progression
- Individuals planning for stem cell transplantation
- Patients requiring personalized treatment strategy development
- Those with family history of hematological malignancies
Clinical Indications and Symptoms
Patients experiencing symptoms such as bone pain, fatigue, recurrent infections, anemia, or kidney dysfunction should discuss this test with their oncologist. The presence of TP53 deletions often correlates with more severe clinical presentations and requires specialized therapeutic approaches.
Benefits of the FISH 17p TP53 Deletion Test
- Prognostic Accuracy: Provides critical information about disease aggressiveness and expected outcomes
- Treatment Guidance: Helps oncologists select the most effective therapeutic regimens
- Risk Stratification: Identifies high-risk patients who may benefit from more intensive treatment
- Monitoring Capability: Enables tracking of genetic changes throughout treatment
- Personalized Medicine: Supports development of tailored treatment strategies
- Early Intervention: Facilitates timely adjustments to therapy based on genetic findings
Understanding Your Test Results
Your FISH 17p TP53 Deletion Test results will be carefully interpreted by our expert cytogeneticists:
Normal Results
A normal result indicates no detectable deletion of the TP53 gene on chromosome 17p. This finding typically suggests standard-risk Multiple Myeloma with potentially better response to conventional treatments.
Abnormal Results
The presence of TP53 deletion indicates high-risk disease characteristics. Patients with this finding may require:
- More aggressive treatment protocols
- Novel therapeutic agents targeting specific pathways
- Closer monitoring and frequent follow-up
- Consideration for clinical trials
Clinical Interpretation
Our comprehensive report includes detailed interpretation by board-certified genetic specialists, explaining the clinical significance of your results and providing recommendations for next steps in your care journey.
Test Pricing and Details
| Test Component | Price (USD) |
|---|---|
| Discount Price | $162 |
| Regular Price | $238 |
Test Specifications
- Turnaround Time: Sample accepted daily by 4 pm; Report delivered in 4 days
- Sample Type: 5 mL (3 mL minimum) whole blood OR 4 mL (2 mL minimum) Bone Marrow from 2 Green Top (Sodium Heparin) tubes
- Shipping Requirements: Ship at 18-22°C. DO NOT FREEZE
- Required Documentation: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory
Nationwide Testing Availability
GGC DNA provides comprehensive genetic testing services across the United States, with convenient locations in major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our network of certified collection centers ensures accessible testing for patients nationwide.
Take Control of Your Health Journey
The FISH 17p TP53 Deletion Test provides invaluable genetic insights that can significantly impact your treatment strategy and long-term outcomes. Don’t leave critical genetic information undiscovered. Our team of genetic specialists is ready to support you through every step of the testing process.
Ready to Schedule Your Test?
Contact our genetic counseling team today to discuss your testing needs and schedule your appointment. Call or WhatsApp us at +1(267) 388-9828 to book your FISH 17p TP53 Deletion Test and take the first step toward personalized cancer care.
Book your test now and receive comprehensive genetic analysis with expert interpretation from our certified cytogenetics laboratory.
