DNMT3A Gene Acute Myeloid Leukemia Somatic NGS Genetic DNA Test
Comprehensive Introduction to DNMT3A Gene Testing
The DNMT3A Gene Acute Myeloid Leukemia Somatic NGS Genetic DNA Test represents a breakthrough in precision oncology, offering unprecedented insights into one of the most critical genetic markers associated with Acute Myeloid Leukemia. This sophisticated diagnostic tool leverages advanced Next-Generation Sequencing technology to identify specific mutations in the DNMT3A gene, which plays a pivotal role in DNA methylation and gene regulation processes essential for normal blood cell development.
Acute Myeloid Leukemia is a rapidly progressing cancer of the blood and bone marrow characterized by the uncontrolled growth of abnormal white blood cells. The DNMT3A gene mutations are among the most frequently observed genetic alterations in AML patients, occurring in approximately 20-30% of cases. These mutations significantly impact disease prognosis, treatment response, and overall survival rates, making their detection crucial for optimal patient management.
What the DNMT3A Test Measures and Detects
Our comprehensive NGS-based test specifically targets and analyzes the DNMT3A gene for somatic mutations that contribute to AML pathogenesis. The test provides detailed information about:
- Point mutations in the DNMT3A gene coding regions
- Frameshift mutations affecting protein function
- Missense mutations altering enzymatic activity
- Nonsense mutations leading to truncated proteins
- Specific hotspot mutations including R882 and other critical residues
The test employs state-of-the-art sequencing technology with high sensitivity, capable of detecting mutations present in as little as 1-5% of cells, ensuring accurate results even in cases with low mutation burden.
Who Should Consider DNMT3A Genetic Testing
This specialized genetic test is recommended for individuals presenting with:
Clinical Indications and Symptoms
- Newly diagnosed Acute Myeloid Leukemia patients
- Individuals with unexplained cytopenias or abnormal blood counts
- Patients with recurrent infections and persistent fatigue
- Those experiencing unexplained bruising or bleeding tendencies
- Individuals with bone pain or enlarged lymph nodes
- Patients with family history of hematological malignancies
- Cases of treatment-resistant or relapsed AML
Risk Assessment Candidates
- Patients with myelodysplastic syndromes progressing to AML
- Individuals with clonal hematopoiesis of indeterminate potential
- Patients undergoing stem cell transplantation evaluation
- Those requiring comprehensive molecular profiling for treatment decisions
Significant Benefits of DNMT3A Testing
Undergoing DNMT3A genetic testing provides numerous clinical advantages:
Diagnostic and Prognostic Value
- Accurate molecular classification of AML subtypes
- Enhanced risk stratification and prognosis assessment
- Identification of high-risk genetic profiles requiring intensive therapy
- Prediction of treatment response and potential resistance
- Monitoring of minimal residual disease during treatment
Therapeutic Implications
- Guidance for targeted therapy selection
- Identification of potential clinical trial eligibility
- Personalized treatment planning based on genetic profile
- Optimization of chemotherapy regimens
- Informed decisions regarding stem cell transplantation
Understanding Your Test Results
Our comprehensive genetic counseling services help you interpret and understand your DNMT3A test results:
Positive Results Interpretation
- Detection of DNMT3A mutations indicates molecular evidence of AML
- Specific mutation types provide prognostic information
- Results guide treatment intensity and duration decisions
- Positive findings may influence stem cell transplant timing
- Regular monitoring may be recommended for mutation clearance
Negative Results Interpretation
- Absence of DNMT3A mutations suggests alternative genetic drivers
- May indicate better prognosis in certain AML subtypes
- Requires consideration of additional genetic testing
- Does not rule out AML diagnosis – comprehensive evaluation needed
- May influence choice of conventional versus targeted therapies
Variant of Uncertain Significance
- Some genetic changes require additional clinical correlation
- Ongoing research may provide future clarity
- Regular follow-up and additional testing may be recommended
- Genetic counseling essential for proper interpretation
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Test Specifications
- Turnaround Time: 3 to 4 Weeks
- Sample Type: Blood, Extracted DNA, or One Drop Blood on FTA Card
- Methodology: Next-Generation Sequencing (NGS) Technology
- Specialty: Oncology Genetics
- Department: Genetics and Molecular Pathology
Nationwide Accessibility and Booking
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified genetic counselors and oncology specialists ensures you receive comprehensive care and support throughout the testing process.
Pre-Test Requirements
Before scheduling your DNMT3A genetic test, please ensure:
- Complete clinical history documentation
- Genetic counseling session to discuss testing implications
- Family pedigree chart development for hereditary assessment
- Oncology specialist consultation and referral
- Insurance pre-authorization when applicable
Take Action Today for Better Health Outcomes
Early detection and precise genetic characterization of Acute Myeloid Leukemia can significantly impact treatment success and long-term outcomes. Our DNMT3A Gene Acute Myeloid Leukemia Somatic NGS Genetic DNA Test provides the critical genetic information needed for informed medical decisions and personalized cancer care.
Ready to schedule your test? Contact our genetic specialists today at +1(267) 388-9828 or book your appointment online. Don’t wait – take control of your health journey with advanced genetic testing from America’s leading diagnostics provider.
Our dedicated team of genetic counselors and oncology specialists are available to answer your questions, discuss testing options, and guide you through every step of the process. With convenient locations nationwide and comprehensive support services, we make advanced genetic testing accessible and understandable for every patient.
