CUL3 Gene Pseudohypoaldosteronism Type 2E NGS Genetic DNA Test
Comprehensive Genetic Analysis for Rare Hypertension Disorders
The CUL3 Gene Pseudohypoaldosteronism Type 2E NGS Genetic DNA Test represents a breakthrough in molecular diagnostics for rare inherited forms of hypertension. This advanced genetic screening utilizes cutting-edge Next-Generation Sequencing technology to identify mutations in the CUL3 gene, which plays a critical role in the ubiquitin-proteasome system regulating blood pressure homeostasis. Pseudohypoaldosteronism Type 2E, also known as Gordon’s syndrome, is characterized by salt-sensitive hypertension, hyperkalemia, and metabolic acidosis due to impaired renal sodium handling.
What Does This Test Measure and Detect?
This comprehensive genetic analysis specifically targets the CUL3 gene located on chromosome 2q36.2, which encodes a core component of the Cullin-RING E3 ubiquitin ligase complex. The test detects:
- Point mutations, insertions, and deletions in the CUL3 gene
- Pathogenic variants affecting protein function
- Genetic alterations disrupting normal blood pressure regulation pathways
- Inherited mutations causing Pseudohypoaldosteronism Type 2E
- Variants affecting renal sodium and potassium balance mechanisms
Who Should Consider This Genetic Test?
Clinical Indications and Symptoms
This test is particularly recommended for individuals presenting with:
- Early-onset hypertension before age 30
- Unexplained hyperkalemia with normal renal function
- Metabolic acidosis without apparent cause
- Family history of similar hypertension patterns
- Resistant hypertension requiring multiple medications
- Electrolyte imbalances despite normal kidney function
- Salt-sensitive blood pressure responses
Key Benefits of CUL3 Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous clinical advantages:
- Accurate Diagnosis: Confirms Pseudohypoaldosteronism Type 2E with molecular precision
- Personalized Treatment: Guides targeted therapeutic approaches including thiazide diuretics
- Family Planning: Enables informed reproductive decisions and genetic counseling
- Early Intervention: Facilitates proactive management before complications develop
- Differential Diagnosis: Distinguishes from other forms of secondary hypertension
- Prognostic Information: Provides insights into disease progression and management
Understanding Your Test Results
Interpretation Guidelines
Your genetic test results will be carefully analyzed and interpreted by our expert geneticists:
- Positive Result: Indicates presence of pathogenic CUL3 mutation confirming diagnosis
- Negative Result: Suggests absence of tested mutations but doesn’t rule out other genetic causes
- Variant of Uncertain Significance: Requires additional family studies and clinical correlation
- Carrier Status: Important for family members and genetic counseling purposes
All positive results include comprehensive genetic counseling to discuss implications, treatment options, and family testing recommendations.
Test Pricing and Details
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
| Turnaround Time | 3-4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified collection centers ensures easy access to this specialized genetic testing regardless of your location.
Take Control of Your Genetic Health Today
Don’t let unexplained hypertension or electrolyte imbalances compromise your quality of life. The CUL3 Gene Pseudohypoaldosteronism Type 2E NGS Genetic DNA Test provides the definitive answers you need for proper diagnosis and targeted treatment. Our experienced genetic counselors are available to discuss your results and guide you through next steps.
Ready to schedule your test? Contact us today at +1(267) 388-9828 or book your appointment online. Take the first step toward understanding your genetic predisposition and optimizing your cardiovascular health management.
