Cryoglobulins Panel Test – Comprehensive Diagnostic Analysis
Understanding Cryoglobulins and Their Clinical Significance
Cryoglobulins are unique immunoglobulins that undergo reversible precipitation when exposed to cold temperatures below 37°C and redissolve upon rewarming. These abnormal proteins can form immune complexes that deposit in small blood vessels, leading to inflammation and tissue damage. The Cryoglobulins Panel Test represents a crucial diagnostic tool for identifying these temperature-sensitive proteins and understanding their role in various autoimmune and inflammatory conditions.
What the Cryoglobulins Panel Test Measures
This comprehensive diagnostic panel specifically detects and characterizes cryoglobulins in blood serum through advanced immunofixation electrophoresis technology. The test measures:
- Presence of cryoglobulins in serum samples
- Quantification of cryoglobulin levels
- Classification into Type I, Type II, or Type III cryoglobulins
- Identification of specific immunoglobulin components (IgM, IgG, IgA)
- Detection of rheumatoid factor activity
Advanced Immunofixation Electrophoresis Methodology
Our laboratory employs state-of-the-art immunofixation electrophoresis techniques to precisely classify cryoglobulins. This sophisticated method separates serum proteins based on their electrical charge and molecular size, followed by specific antibody reactions that identify the exact immunoglobulin composition of the cryoprecipitate.
Who Should Consider the Cryoglobulins Panel Test
This test is particularly important for individuals experiencing symptoms suggestive of cryoglobulinemia or related autoimmune conditions:
- Patients with recurrent skin purpura or vasculitic lesions
- Individuals experiencing joint pain and arthritis symptoms
- Those with unexplained kidney dysfunction or proteinuria
- Patients with peripheral neuropathy or neurological symptoms
- Individuals with Raynaud’s phenomenon
- Patients with hepatitis C infection or other chronic infections
- Those with autoimmune disorders like lupus or rheumatoid arthritis
- Individuals with unexplained fever, fatigue, or weight loss
Clinical Benefits of Cryoglobulins Testing
Early detection and characterization of cryoglobulins provide numerous clinical advantages:
- Accurate Diagnosis: Helps confirm cryoglobulinemia and differentiate between types
- Treatment Guidance: Informs appropriate therapeutic strategies based on cryoglobulin type
- Disease Monitoring: Tracks treatment response and disease progression
- Risk Assessment: Identifies patients at risk for severe complications
- Prognostic Information: Provides insights into disease severity and potential outcomes
Understanding Your Test Results
Interpreting cryoglobulins panel results requires careful clinical correlation:
Negative Results
A negative result indicates no detectable cryoglobulins in the serum sample. However, this doesn’t completely rule out cryoglobulinemia, as levels can fluctuate or be below detection limits during testing.
Positive Results and Classification
Positive results are classified into three main types:
- Type I: Monoclonal immunoglobulins, typically associated with hematological malignancies
- Type II: Mixed cryoglobulins with monoclonal rheumatoid factor, often linked to hepatitis C infection
- Type III: Polyclonal mixed cryoglobulins, commonly associated with autoimmune diseases
Quantitative Interpretation
The cryocrit value (percentage of cryoprecipitate) provides additional clinical information, with higher values often correlating with more severe disease manifestations.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $200 |
| Regular Price | $300 |
Test Specifications and Requirements
Sample Collection Protocol
Proper sample collection is critical for accurate cryoglobulins testing:
- Sample Volume: 3 mL (1.5 mL minimum) serum
- Collection Tube: PREWARMED Red Top (No Additive) tube
- Collection Method: PRE-WARMED syringe and needle at 37°C
- Processing: Allow to clot and centrifuge preferably at 37°C
- Transport: Separate serum and transport at room temperature
- Important Notes: DO NOT FREEZE. Do not use SST gel barrier tubes
Turnaround Time
Our laboratory processes samples daily by 9 AM, with results typically available within 5 days from sample receipt.
Preparation Requirements
No special patient preparation is required before sample collection for the Cryoglobulins Panel Test.
Nationwide Testing Availability
GGC DNA maintains comprehensive testing facilities across the United States, with branches in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, and Philadelphia. Our network ensures convenient access to specialized diagnostic services for patients nationwide.
Take Action for Your Health
Don’t let unexplained symptoms go undiagnosed. The Cryoglobulins Panel Test provides essential information for identifying autoimmune conditions and complement system disorders. Early detection can lead to more effective treatment and improved quality of life.
Book your Cryoglobulins Panel Test today by calling our dedicated healthcare line at +1(267) 388-9828 or schedule your appointment online. Our experienced medical team is ready to assist you with comprehensive diagnostic services and personalized care.
