Cortisol Serum Midnight Sample Test
Understanding Cortisol and Its Importance
Cortisol is a vital steroid hormone produced by the adrenal glands that plays a crucial role in regulating numerous bodily functions, including metabolism, immune response, blood pressure, and stress management. The Cortisol Serum Midnight Sample Test is a specialized diagnostic tool designed to measure cortisol levels during the late evening hours when they should naturally be at their lowest point in the body’s 24-hour circadian rhythm.
What the Test Measures and Detects
This test specifically measures the concentration of cortisol in your blood serum collected between 10 PM and midnight. Unlike random cortisol tests, this timed measurement provides critical information about your body’s natural cortisol rhythm. The test helps detect:
- Abnormal cortisol secretion patterns
- Cushing’s syndrome (excess cortisol production)
- Adrenal gland dysfunction
- Pituitary gland disorders affecting cortisol regulation
- Disruption of normal circadian cortisol rhythm
Who Should Consider This Test
This test is recommended for individuals experiencing symptoms that may indicate cortisol imbalance or adrenal disorders:
- Unexplained weight gain, particularly in the face and abdomen
- High blood pressure that’s difficult to control
- Mood swings, anxiety, or depression
- Muscle weakness and fatigue
- Irregular menstrual cycles in women
- Purple stretch marks on the skin
- Buffalo hump (fat accumulation between shoulders)
- Thinning skin that bruises easily
- Increased thirst and urination
Benefits of Taking the Cortisol Midnight Test
Undergoing this specialized test offers numerous advantages for your health assessment:
- Early Detection: Identifies adrenal disorders before they progress to more serious complications
- Accurate Diagnosis: Provides precise information about cortisol rhythm abnormalities
- Treatment Guidance: Helps healthcare providers develop targeted treatment plans
- Monitoring Tool: Allows tracking of treatment effectiveness for adrenal conditions
- Comprehensive Assessment: Complements other endocrine tests for complete adrenal evaluation
Test Methodology and Procedure
The Cortisol Serum Midnight Sample Test utilizes advanced Chemiluminescent Immunoassay technology, providing highly accurate and reliable results. The testing process involves:
- Blood sample collection between 10 PM and midnight
- Requirement of 2 mL (minimum 1 mL) serum from one SST tube
- Proper labeling with exact collection time and date
- Refrigerated or frozen shipment to maintain sample integrity
- Daily turnaround time for prompt results
Understanding Your Test Results
Interpreting your Cortisol Serum Midnight Sample Test results requires professional medical guidance, but here’s general information about what the findings might indicate:
- Normal Results: Low cortisol levels (typically below 5 mcg/dL) suggest normal adrenal function and circadian rhythm
- Elevated Levels: High midnight cortisol may indicate Cushing’s syndrome or other adrenal disorders
- Follow-up Testing: Abnormal results often require additional testing, such as dexamethasone suppression tests or 24-hour urinary free cortisol measurements
- Clinical Correlation: Results should always be interpreted in context with your symptoms, medical history, and other test findings
Test Pricing Information
| Test Name | Price |
|---|---|
| Cortisol Serum Midnight Sample Test | $16 USD (Discounted) |
| Regular Price | $18 USD |
Nationwide Testing Availability
GGC DNA provides comprehensive Cortisol Serum Midnight Sample testing services across the United States. We have conveniently located branches in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art facilities ensure accurate testing and reliable results for patients nationwide.
Take Control of Your Adrenal Health Today
Don’t let unexplained symptoms affect your quality of life. The Cortisol Serum Midnight Sample Test provides valuable insights into your adrenal function and can help identify underlying hormonal imbalances. With our affordable pricing at only $16 USD and daily turnaround times, getting the answers you need has never been more accessible.
Ready to schedule your test? Call or WhatsApp us today at +1(267) 388-9828 to book your appointment at any of our nationwide locations. Our experienced healthcare professionals are ready to assist you with comprehensive adrenal function testing and personalized care.

