Coombs Test Direct – Comprehensive Diagnostic Testing
Understanding the Coombs Test Direct
The Coombs Test Direct, clinically known as the Direct Antiglobulin Test (DAT), represents a cornerstone diagnostic procedure in hematological medicine. This sophisticated immunological assay plays a vital role in detecting antibodies that have attached directly to the surface of red blood cells, providing critical insights into various hemolytic conditions and immune-mediated blood disorders.
What Does the Coombs Test Direct Measure?
The Coombs Test Direct specifically identifies and detects:
- IgG antibodies bound to erythrocyte surfaces
- Complement proteins (C3d, C3b) attached to red blood cells
- Immune-mediated destruction of red blood cells
- Autoimmune hemolytic processes
- Transfusion-related immunological reactions
Clinical Importance and Applications
This test serves as an essential diagnostic tool for hematologists and gynecologists in evaluating patients with suspected immune-mediated hemolytic conditions. The Coombs Test Direct helps differentiate between various types of hemolytic anemias and guides appropriate therapeutic interventions, making it indispensable in clinical practice.
Who Should Consider This Test?
Patients experiencing the following symptoms or conditions should discuss Coombs Test Direct with their healthcare provider:
- Unexplained anemia or persistent fatigue
- Jaundice or yellowing of skin and eyes
- Dark-colored urine (hemoglobinuria)
- Recent blood transfusion with adverse reactions
- Suspected hemolytic disease of the newborn
- Autoimmune disorders with hematological manifestations
- Unexplained splenomegaly or hepatomegaly
- Medication-induced hemolytic reactions
Advanced Testing Methodology
At GGC DNA, we employ state-of-the-art Erythrocyte Magnetised Technology for Coombs Test Direct analysis. This innovative approach ensures:
- Enhanced sensitivity in antibody detection
- Superior specificity for accurate results
- Rapid processing with same-day reporting
- Minimal sample requirements
- Consistent, reliable outcomes
Key Benefits of Coombs Test Direct
- Rapid Diagnosis: Same-day results enable prompt clinical decision-making
- No Special Preparation: Convenient testing without dietary restrictions
- Comprehensive Analysis: Detects both IgG and complement-mediated hemolysis
- Expert Interpretation: Results reviewed by specialized immunopathologists
- Nationwide Accessibility: Available at all GGC DNA locations across USA
Understanding Your Test Results
Your Coombs Test Direct results will be clearly interpreted by our expert team:
Positive Result Interpretation
- IgG Positive: Indicates autoimmune hemolytic anemia or drug-induced hemolysis
- Complement Positive: Suggests cold agglutinin disease or immune complex-mediated hemolysis
- Mixed Positive: Both IgG and complement detected, requiring comprehensive evaluation
Negative Result Interpretation
- No evidence of antibody-mediated red cell destruction
>May suggest non-immune hemolytic mechanisms
>Requires correlation with clinical presentation
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Coombs Test Direct | $14 USD | $16 USD |
Sample Requirements and Processing
- Sample Type: 3 mL (2 mL minimum) whole blood from 1 Lavender Top (EDTA) tube
- Transport: Ship refrigerated – DO NOT FREEZE
- Turnaround Time: Sample daily by 9 am; Report same day
- Preparation: No special preparation required
Nationwide Testing Network
GGC DNA maintains comprehensive testing facilities across all major cities in the United States, including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our extensive network ensures convenient access to Coombs Test Direct services regardless of your location.
Why Choose GGC DNA for Your Testing Needs?
- Board-certified hematologists and immunopathologists
- Advanced Erythrocyte Magnetised Technology
- Same-day result availability
- Competitive pricing with discount options
- Comprehensive patient support and counseling
- Nationwide laboratory accreditation
Take Action Today
Don’t let unexplained symptoms compromise your health. The Coombs Test Direct provides crucial diagnostic information that can guide effective treatment strategies for hematological disorders. Our team of specialists is ready to assist you with comprehensive testing and expert interpretation.
Book your Coombs Test Direct today by calling +1(267) 388-9828 or visiting your nearest GGC DNA location. Same-day appointments available for urgent diagnostic needs.
Experience the peace of mind that comes with accurate, timely diagnostic testing from America’s leading genetics and diagnostics provider. Trust GGC DNA for your Coombs Test Direct and comprehensive hematological evaluation.
