Chromosome Analysis Products of Conception Reflex Testing to FISH for Aneuploidy Detection
Comprehensive Genetic Analysis for Pregnancy Loss Evaluation
The Chromosome Analysis Products of Conception with FISH Aneuploidy Detection represents a sophisticated diagnostic approach for investigating the genetic causes of pregnancy loss. This integrated testing protocol combines traditional cytogenetic methods with advanced molecular techniques to provide a comprehensive assessment of chromosomal integrity in fetal tissue. Understanding the genetic basis of miscarriage is crucial for providing appropriate medical care, emotional closure, and informed reproductive planning for affected couples.
What This Advanced Genetic Test Measures
This comprehensive diagnostic procedure evaluates multiple aspects of chromosomal health and structure:
- Chromosomal Aneuploidies: Detects abnormal chromosome numbers, including trisomies and monosomies
- Structural Abnormalities: Identifies chromosomal rearrangements, deletions, and duplications
- Mosaicism: Assesses for the presence of multiple cell lines with different chromosomal compositions
- Common Aneuploidies: Specifically targets chromosomes 13, 18, 21, X, and Y using FISH technology
- Karyotype Analysis: Provides a complete chromosomal picture through microscopic examination
Who Should Consider This Genetic Testing
This specialized testing is particularly recommended for:
- Couples experiencing recurrent pregnancy loss (two or more miscarriages)
- Women with a history of unexplained stillbirth
- Patients with advanced maternal age (35 years and older)
- Couples with previous pregnancies affected by chromosomal abnormalities
- Women with abnormal ultrasound findings in current or previous pregnancies
- Patients seeking closure and understanding after pregnancy loss
- Couples planning future pregnancies who want genetic risk assessment
Significant Benefits of Chromosomal Analysis
Undergoing this comprehensive genetic evaluation offers multiple advantages:
- Clarification of Cause: Provides definitive answers about whether chromosomal abnormalities contributed to pregnancy loss
- Emotional Closure: Helps couples understand the medical reasons behind their loss, reducing self-blame
- Future Planning Guidance: Informs reproductive decisions and potential interventions for subsequent pregnancies
- Risk Assessment: Helps determine recurrence risks for future pregnancies
- Medical Management: Guides appropriate medical follow-up and genetic counseling
- Comprehensive Analysis: Combines traditional and molecular methods for enhanced detection capability
Understanding Your Test Results
Normal Results Interpretation
A normal chromosomal result indicates that no significant numerical or structural abnormalities were detected in the analyzed tissue. This finding suggests that the pregnancy loss may have been due to non-chromosomal factors, such as uterine abnormalities, hormonal issues, immune factors, or other medical conditions. However, it’s important to note that some subtle genetic abnormalities may not be detectable with current testing methods.
Abnormal Results Guidance
Abnormal results typically indicate the presence of chromosomal abnormalities that likely contributed to the pregnancy loss:
- Trisomies: The most common finding, particularly involving chromosomes 13, 16, 18, 21, or 22
- Monosomy X: Associated with Turner syndrome
- Triploidy: Presence of three complete sets of chromosomes
- Structural Rearrangements: Translocations or other chromosomal rearrangements
When abnormal results are obtained, genetic counseling is strongly recommended to discuss the implications for future pregnancies and available testing options.
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | Chromosome Analysis Products of Conception Reflex Testing to FISH for Aneuploidy Detection |
| Regular Price | $300 USD |
| Discount Price | $212 USD |
| Turnaround Time | 4-5 weeks |
| Sample Type | Submit curetted tissue in normal saline (Fetus not accepted) |
| Shipping Requirements | Ship immediately at 18-22°C. Specimens must reach laboratory within 24 hours |
| Specialty | Gynecologist, Cytogenetics |
| Testing Methods | Culture, Microscopy, Karyotype, FISH |
Important Pre-Test Instructions
To ensure accurate results, please follow these critical preparation guidelines:
- Mandatory Documentation: Duly filled Chromosome & FISH Analysis Requisition form (Form 17) is required
- Sample Collection: Submit curetted tissue in normal saline only
- Exclusions: Formalin fixed specimens are not acceptable
- Timely Shipping: Specimens must be shipped immediately and reach the laboratory within 24 hours
- Temperature Control: Maintain specimens at 18-22°C during transport
Nationwide Availability and Booking
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network of certified laboratories ensures consistent, high-quality testing standards nationwide.
Take the Next Step Toward Understanding
If you’ve experienced pregnancy loss and want to understand the potential genetic factors involved, this comprehensive chromosomal analysis can provide valuable insights. Our team of genetic specialists and counselors are available to discuss your situation and help you make informed decisions about your reproductive health.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your Chromosome Analysis Products of Conception test or to speak with a genetic counselor about your specific situation.
Don’t let unanswered questions about pregnancy loss prevent you from moving forward with confidence. Our advanced genetic testing provides the clarity you need to make informed decisions about your reproductive future.
