CDON Gene Holoprosencephaly Type 11 NGS Genetic DNA Test
Comprehensive Genetic Testing for Brain Development Disorders
The CDON Gene Holoprosencephaly Type 11 NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for developmental brain disorders. This specialized test utilizes next-generation sequencing technology to analyze the CDON gene, which plays a critical role in embryonic brain development and forebrain formation. Holoprosencephaly type 11 is a rare congenital condition characterized by incomplete separation of the cerebral hemispheres, and mutations in the CDON gene are directly responsible for this specific genetic subtype.
What Does This Test Measure and Detect?
This advanced genetic test specifically targets and sequences the entire CDON gene to identify pathogenic variants, including:
- Point mutations and single nucleotide variants
- Small insertions and deletions
- Copy number variations affecting the CDON gene
- Novel mutations previously unidentified
- Inherited familial variants
The test employs state-of-the-art NGS technology that provides comprehensive coverage of the CDON gene region, ensuring high accuracy and reliability in mutation detection. Our laboratory follows strict quality control protocols and adheres to ACMG guidelines for variant interpretation.
Who Should Consider This Genetic Test?
This test is particularly recommended for individuals presenting with:
- Clinical features suggestive of holoprosencephaly spectrum disorders
- Family history of holoprosencephaly or related craniofacial abnormalities
- Unexplained developmental delays with midline facial defects
- Previous pregnancies with neural tube defects or brain malformations
- Children with characteristic facial features including cyclopia, proboscis, or single central incisor
- Individuals with microcephaly or other brain development concerns
Clinical Benefits of CDON Gene Testing
Undergoing the CDON Gene Holoprosencephaly Type 11 test provides numerous clinical advantages:
- Definitive Diagnosis: Confirms or rules out CDON-related holoprosencephaly with high accuracy
- Genetic Counseling: Enables informed family planning decisions and recurrence risk assessment
- Early Intervention: Facilitates timely medical management and developmental support
- Prenatal Planning: Provides crucial information for future pregnancies
- Research Contribution: Helps advance understanding of rare genetic disorders
- Peace of Mind: Reduces uncertainty and provides clear genetic information
Understanding Your Test Results
Our comprehensive genetic report provides detailed interpretation of your results:
- Positive Result: Indicates the presence of a pathogenic CDON gene mutation. This confirms the diagnosis of holoprosencephaly type 11 and provides specific information about the identified variant.
- Negative Result: No pathogenic mutations detected in the CDON gene. This significantly reduces the likelihood of CDON-related holoprosencephaly but doesn’t exclude other genetic causes.
- Variant of Uncertain Significance (VUS): Identifies genetic changes with unclear clinical significance. Additional family studies may be recommended.
All results are accompanied by detailed clinical interpretation and recommendations from our board-certified genetic counselors. We provide guidance on next steps, including additional testing options and management strategies.
Test Pricing and Sample Requirements
| Test Component | Details |
|---|---|
| Test Name | CDON Gene Holoprosencephaly Type 11 NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
Pre-Test Requirements and Genetic Counseling
Before testing, we recommend:
- Complete clinical history documentation of the patient
- Genetic counseling session to discuss test implications
- Development of a detailed family pedigree chart
- Discussion of potential outcomes and their meanings
- Informed consent process explaining benefits and limitations
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, including major metropolitan areas such as New York City, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, and many other cities. Our network ensures accessible genetic testing services for families throughout the country.
Take the Next Step Toward Genetic Clarity
If you or your family members are concerned about holoprosencephaly or related developmental disorders, the CDON Gene Holoprosencephaly Type 11 NGS Genetic DNA Test provides the definitive answers you need. Our team of genetic specialists is ready to guide you through the testing process and help interpret your results.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Take control of your genetic health with confidence and clarity.
