CARD14 Gene Pityriasis Rubra Pilaris NGS Genetic DNA Test
Comprehensive Genetic Analysis for Inflammatory Skin Disorders
The CARD14 Gene Pityriasis Rubra Pilaris NGS Genetic DNA Test represents a breakthrough in dermatological genetic testing, offering precise identification of mutations responsible for pityriasis rubra pilaris (PRP). This rare inflammatory skin condition affects approximately 1 in 400,000 individuals and can significantly impact quality of life. Our advanced next-generation sequencing technology provides comprehensive analysis of the CARD14 gene, enabling accurate diagnosis and personalized treatment approaches.
What Does This Test Measure and Detect?
This sophisticated genetic test specifically targets the CARD14 (caspase recruitment domain family member 14) gene, which plays a crucial role in regulating inflammatory responses in the skin. The test detects:
- Pathogenic variants in the CARD14 gene associated with autosomal dominant PRP
- Specific mutations that lead to abnormal NF-kB pathway activation
- Genetic variations responsible for familial and sporadic cases of pityriasis rubra pilaris
- Novel and known mutations using comprehensive NGS analysis
Who Should Consider This Genetic Test?
This test is particularly recommended for individuals experiencing:
- Widespread orange-red scaling and erythema covering large body areas
- Characteristic follicular papules with central keratotic plugs
- Palmoplantar keratoderma with orange-yellow thickening
- Family history of similar skin conditions or confirmed PRP diagnosis
- Resistant skin inflammation unresponsive to conventional treatments
- Suspected genetic basis for chronic inflammatory dermatosis
Significant Benefits of Genetic Testing
Undergoing the CARD14 Gene Pityriasis Rubra Pilaris NGS Genetic DNA Test provides numerous advantages:
- Accurate Diagnosis: Confirms or rules out genetic basis for skin symptoms
- Personalized Treatment: Informs targeted therapeutic approaches based on genetic findings
- Family Planning: Provides crucial information for genetic counseling and reproductive decisions
- Early Intervention: Enables proactive management before severe symptoms develop
- Disease Prognosis: Helps predict disease course and potential complications
- Research Contribution: Advances understanding of rare genetic skin disorders
Understanding Your Test Results
Our comprehensive genetic analysis provides detailed insights into your CARD14 gene status:
- Positive Result: Indicates presence of pathogenic CARD14 mutation, confirming genetic basis for PRP symptoms
- Negative Result: Suggests symptoms may have alternative causes, requiring further dermatological evaluation
- Variant of Uncertain Significance: Identifies genetic changes requiring additional clinical correlation
- Carrier Status: Determines inheritance patterns and family member risk assessment
All results include detailed interpretation by our certified genetic counselors and dermatology specialists, ensuring you receive comprehensive guidance for next steps.
Test Specifications and Pricing
| Test Component | Details |
|---|---|
| Test Name | CARD14 Gene Pityriasis Rubra Pilaris NGS Genetic DNA Test |
| Regular Price | $700 USD |
| Discount Price | $500 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Testing Method | Next-Generation Sequencing (NGS) Technology |
Pre-Test Requirements and Preparation
To ensure optimal testing outcomes, we recommend:
- Complete clinical history documentation of the patient
- Genetic counseling session to create detailed family pedigree chart
- Documentation of affected family members with similar symptoms
- Current dermatological assessment and treatment history
- Informed consent for genetic testing and potential implications
Nationwide Accessibility and Convenience
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified collection centers ensures easy access to this advanced genetic testing.
Take Control of Your Skin Health Today
Don’t let uncertainty about your skin condition affect your quality of life. Our CARD14 Gene Pityriasis Rubra Pilaris NGS Genetic DNA Test provides the clarity you need for proper diagnosis and effective treatment planning. With our discounted price of $500 USD and comprehensive genetic analysis, you can make informed decisions about your dermatological health.
Ready to begin your genetic testing journey? Contact our specialists today at +1(267) 388-9828 or book your appointment online. Our genetic counselors are available to answer your questions and guide you through the testing process.
