CARD11 Gene Immunodeficiency Type 11 NGS Genetic DNA Test
Comprehensive Genetic Analysis for Immune System Disorders
The CARD11 Gene Immunodeficiency Type 11 NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for immune system disorders. This advanced test specifically targets the CARD11 gene, which encodes a critical protein involved in nuclear factor kappa B (NF-κB) signaling pathway activation. When mutations occur in this gene, they can disrupt normal immune cell function, leading to various immunodeficiency conditions that affect multiple body systems including dermatology, osteology, and immunology.
What Does This Test Measure and Detect?
This comprehensive genetic analysis utilizes Next-Generation Sequencing (NGS) technology to identify specific mutations within the CARD11 gene. The test detects:
- Point mutations affecting protein structure and function
- Insertions and deletions that disrupt gene expression
- Splice site variants impacting mRNA processing
- Regulatory region mutations affecting gene regulation
- Compound heterozygous mutations in familial cases
The CARD11 protein functions as a scaffold protein in the CARD11-BCL10-MALT1 (CBM) complex, which is essential for antigen receptor-mediated NF-κB activation in lymphocytes. Mutations in this gene can lead to either gain-of-function or loss-of-function phenotypes, resulting in distinct clinical presentations ranging from severe combined immunodeficiency to autoimmune lymphoproliferative syndromes.
Who Should Consider This Test?
This genetic test is particularly recommended for individuals presenting with:
- Recurrent severe bacterial, viral, or fungal infections
- Chronic skin conditions including eczema, psoriasis, or dermatitis
- Autoimmune manifestations affecting multiple organ systems
- Family history of immunodeficiency disorders
- Unexplained inflammatory conditions
- Growth and developmental delays in children
- Multiple hospitalizations for infectious diseases
- Poor response to conventional treatments
Clinical Benefits of Genetic Testing
Undergoing the CARD11 Gene Immunodeficiency Type 11 NGS Genetic DNA Test provides numerous clinical advantages:
- Accurate Diagnosis: Provides definitive genetic confirmation of immunodeficiency type 11
- Personalized Treatment: Enables targeted therapeutic approaches based on specific mutation type
- Family Planning: Offers genetic counseling for family members and future pregnancies
- Early Intervention: Facilitates proactive management before severe complications develop
- Disease Monitoring: Establishes baseline for tracking disease progression and treatment response
- Research Contribution: Contributes to ongoing medical research and understanding of immune disorders
Understanding Your Test Results
Your genetic test results will be carefully interpreted by our team of genetic specialists and immunologists. The report will include:
- Mutation Classification: Pathogenic, likely pathogenic, variant of uncertain significance, likely benign, or benign
- Clinical Correlation: How the identified mutation relates to your symptoms and medical history
- Inheritance Pattern: Information about autosomal dominant or recessive inheritance
- Management Recommendations: Specific guidance for clinical management and monitoring
- Family Testing Suggestions: Recommendations for testing other family members
Our genetic counselors will provide comprehensive post-test counseling to help you understand your results and their implications for your health management.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | CARD11 Gene Immunodeficiency Type 11 NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, serving major metropolitan areas including New York City, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art laboratories ensure consistent, high-quality testing results regardless of your location.
Pre-Test Requirements
Before undergoing testing, we recommend:
- Comprehensive clinical history documentation
- Genetic counseling session to discuss testing implications
- Development of a detailed family pedigree chart
- Review of potential insurance coverage options
- Discussion of psychological preparedness for results
Take Control of Your Health Today
Don’t let unexplained symptoms or family history of immune disorders remain a mystery. The CARD11 Gene Immunodeficiency Type 11 NGS Genetic DNA Test provides the clarity needed for proper diagnosis and management. Our team of genetic specialists, immunologists, and dermatologists are ready to support you through every step of the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Take the first step toward understanding your genetic health and developing an effective management strategy for immune system disorders.
