BRAF Gene Selective Sequencing of Exon 15 NGS Genetic DNA Test
Comprehensive Introduction to BRAF Gene Testing
The BRAF Gene Selective Sequencing of Exon 15 NGS Genetic DNA Test represents a breakthrough in precision oncology, offering targeted analysis of one of the most critical genetic regions in cancer development. This sophisticated diagnostic tool utilizes Next-Generation Sequencing (NGS) technology to specifically examine exon 15 of the BRAF gene, where the majority of clinically significant mutations occur. The BRAF gene encodes a protein that plays a vital role in regulating cell growth and division through the MAPK/ERK signaling pathway. When mutations occur in this gene, particularly in exon 15, they can lead to uncontrolled cell proliferation and cancer development.
What This Advanced Test Detects
Our specialized NGS-based test precisely identifies mutations within exon 15 of the BRAF gene, with particular focus on:
- BRAF V600E mutation – the most common and clinically relevant alteration
- Other V600 mutations including V600K, V600D, and V600R
- Rare exon 15 mutations that may impact treatment decisions
- Specific nucleotide changes that activate the MAPK signaling pathway
Clinical Significance of BRAF Mutations
BRAF mutations, especially those in exon 15, drive tumor growth in multiple cancer types and serve as important biomarkers for targeted therapy selection. The detection of these mutations helps oncologists determine eligibility for BRAF inhibitor treatments and predict treatment response.
Who Should Consider BRAF Gene Testing
This specialized genetic test is recommended for individuals with:
- Diagnosed melanoma seeking targeted therapy options
- Colorectal cancer patients for treatment stratification
- Thyroid cancer cases requiring mutation analysis
- Non-small cell lung cancer with suspected BRAF mutations
- Patients with family history of BRAF-related cancers
- Individuals with multiple cancers or unusual tumor presentations
Symptoms and Clinical Indications
Patients experiencing unexplained skin lesions, persistent digestive issues, thyroid nodules, or those with confirmed cancer diagnoses should discuss BRAF testing with their healthcare provider. Early detection of BRAF mutations can significantly impact treatment planning and outcomes.
Key Benefits of BRAF Genetic Testing
- Personalized Treatment Planning: Identifies patients who may benefit from targeted BRAF inhibitor therapies
- Improved Prognostic Information: Provides valuable insights into disease progression and treatment response
- Family Risk Assessment: Helps identify hereditary cancer syndromes and assess family member risks
- Therapeutic Guidance: Informs treatment decisions for multiple cancer types including melanoma and colorectal cancer
- Comprehensive Analysis: Utilizes advanced NGS technology for accurate and reliable results
Understanding Your Test Results
Your BRAF gene test results will fall into one of several categories:
Positive for BRAF Mutation
A positive result indicates the presence of a BRAF mutation in exon 15. This finding may make you eligible for targeted therapies such as BRAF inhibitors. Your oncologist will discuss specific treatment options based on the exact mutation detected and your cancer type.
Negative for BRAF Mutation
A negative result means no clinically significant BRAF mutations were detected in exon 15. This information helps guide treatment away from BRAF-targeted therapies and toward other appropriate options.
Variant of Uncertain Significance
In some cases, the test may identify genetic changes whose clinical significance is not yet fully understood. Your genetic counselor and oncologist will help interpret these findings in the context of your specific situation.
Test Pricing and Details
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Additional Test Information
- Turnaround Time: 3 to 4 weeks
- Sample Type: Blood, Extracted DNA, or One drop Blood on FTA Card
- Methodology: Next-Generation Sequencing (NGS) Technology
- Specialty: Oncology Genetics
Pre-Test Requirements
Before undergoing BRAF gene testing, patients should provide:
- Complete clinical history relevant to the testing indication
- Participation in a genetic counseling session
- Development of a pedigree chart documenting family members affected by BRAF-related conditions
- Informed consent understanding the implications of genetic testing
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major cities including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified genetic counselors and oncology specialists ensures you receive comprehensive care regardless of your location.
Take Control of Your Cancer Care Today
Don’t leave your treatment decisions to chance. The BRAF Gene Selective Sequencing of Exon 15 NGS Genetic DNA Test provides critical information that can transform your cancer treatment journey. With our discounted price of $500 and comprehensive nationwide coverage, advanced genetic testing has never been more accessible.
Ready to schedule your test? Call our dedicated genetics team at +1(267) 388-9828 or book your appointment online. Our genetic counselors are available to answer your questions and guide you through the testing process.
Take the first step toward personalized cancer care with the most advanced BRAF genetic testing available. Your journey to targeted treatment begins with a single phone call.
