BCR-ABL Variant Panel: Comprehensive Genetic Testing for Leukemia Detection
Understanding the BCR-ABL Variant Panel Test
The BCR-ABL Variant Panel represents a breakthrough in molecular diagnostics for hematological malignancies. This sophisticated genetic test specifically targets the Philadelphia chromosome abnormality, which results from a reciprocal translocation between chromosomes 9 and 22. This chromosomal rearrangement creates the BCR-ABL fusion gene, a well-established driver mutation in several types of leukemia.
At General Genetics Corporation, we utilize state-of-the-art Multiplex End Point PCR technology to deliver highly accurate and reliable results. Our test is designed to detect the most common BCR-ABL variants, including b2a2, b3a2, and b2a3, providing comprehensive genetic profiling essential for modern leukemia management.
What the Test Measures and Detects
The BCR-ABL Variant Panel specifically identifies:
- BCR-ABL b2a2 variant: The most common fusion transcript in chronic myeloid leukemia
- BCR-ABL b3a2 variant: Another frequent fusion transcript with clinical significance
- BCR-ABL b2a3 variant: Less common but clinically important fusion transcript
- Presence of Philadelphia chromosome-related genetic abnormalities
- Quantitative assessment of fusion gene expression levels
This test provides crucial information about the specific genetic makeup of leukemia cells, enabling precise diagnosis and targeted treatment approaches.
Who Should Consider This Test?
Clinical Indications and Symptoms
This test is recommended for individuals experiencing:
- Unexplained fatigue, weakness, or persistent tiredness
- Unexplained weight loss and night sweats
- Abdominal discomfort or fullness due to spleen enlargement
- Frequent infections or unusual bleeding/bruising
- Bone pain or joint discomfort
- Abnormal blood counts detected during routine examinations
- Family history of hematological malignancies
- Suspected or confirmed diagnosis of chronic myeloid leukemia (CML)
- Patients with acute lymphoblastic leukemia (ALL)
- Individuals requiring monitoring of treatment response to tyrosine kinase inhibitors
Benefits of Taking the BCR-ABL Variant Panel
Choosing our comprehensive genetic testing provides numerous advantages:
- Early and Accurate Diagnosis: Detect leukemia at molecular levels before clinical symptoms become severe
- Personalized Treatment Planning: Guide selection of targeted therapies like imatinib, dasatinib, or nilotinib
- Treatment Monitoring: Track response to therapy and detect emerging resistance
- Minimal Residual Disease Detection: Identify low levels of leukemia cells that may cause relapse
- Prognostic Information: Understand disease progression and long-term outcomes
- Family Risk Assessment: Provide genetic counseling for family members
Understanding Your Test Results
Interpretation Guidelines
Your BCR-ABL Variant Panel results will provide detailed information about:
- Positive Result: Indicates presence of BCR-ABL fusion gene, confirming Philadelphia chromosome-positive leukemia
- Negative Result: Suggests absence of detectable BCR-ABL fusion genes
- Variant Identification: Specific detection of b2a2, b3a2, or b2a3 variants
- Quantitative Levels: Measurement of fusion gene expression for treatment monitoring
Important Note: All results should be interpreted by a qualified hematologist or oncologist in the context of your complete clinical picture. Our genetic counselors are available to help you understand your results and discuss next steps.
Test Information and Pricing
| Test Parameter | Details |
|---|---|
| Test Name | BCR-ABL Variant Panel |
| Discount Price | $226 USD |
| Regular Price | $300 USD |
| Turnaround Time | 5-7 days |
| Sample Type | Bone marrow / Peripheral blood (Transport immediately) |
| Test Components | EDTA Vacutainer (4ml) |
| Testing Method | Multlex End Point PCR |
| Medical Specialty | Genetic Hematology |
Pre-Test Instructions and Requirements
The BCR-ABL Variant Panel requires a Doctor’s prescription for most cases. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad. Please ensure proper sample collection and immediate transport to maintain sample integrity.
Nationwide Availability
We have branches across all major cities in the USA, including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, San Francisco, and many more. Our state-of-the-art laboratories ensure consistent, high-quality testing nationwide.
Take Control of Your Health Today
Don’t wait to get the answers you need for proper leukemia diagnosis and management. Our BCR-ABL Variant Panel provides the critical genetic information required for effective treatment planning and monitoring.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your appointment or speak with our genetic counseling team.
Early detection through comprehensive genetic testing can significantly improve treatment outcomes and quality of life. Trust General Genetics Corporation for accurate, reliable, and timely genetic testing services.
