BCL2/IGH t(14;18) FISH Test – Advanced Genetic Testing for Lymphoma Diagnosis
Understanding the BCL2/IGH t(14;18) Genetic Test
The BCL2/IGH t(14;18) FISH test represents a cornerstone in modern molecular oncology, providing critical insights into the genetic underpinnings of B-cell lymphomas. This sophisticated diagnostic tool detects a specific chromosomal translocation that occurs when genetic material from chromosome 14 and chromosome 18 abnormally fuse together. This translocation creates a powerful oncogenic event that disrupts the body’s natural ability to regulate cell death, leading to uncontrolled lymphocyte proliferation and the development of lymphoma.
What Does the BCL2/IGH t(14;18) Test Measure?
This advanced genetic test specifically identifies the presence of the t(14;18) chromosomal translocation, which involves:
- BCL2 Gene Detection: Identifies abnormalities in the BCL2 gene located on chromosome 18
- IGH Gene Analysis: Examines the immunoglobulin heavy chain gene on chromosome 14
- Translocation Confirmation: Detects the fusion between BCL2 and IGH genes
- Fluorescence In Situ Hybridization (FISH): Utilizes cutting-edge molecular technology for precise chromosomal analysis
Who Should Consider BCL2/IGH t(14;18) Testing?
This specialized genetic test is recommended for individuals presenting with:
- Suspected or confirmed follicular lymphoma cases
- Unexplained lymph node enlargement or swelling
- Persistent fatigue and unexplained weight loss
- Night sweats and recurrent fevers without infection
- Abnormal blood cell counts suggesting hematologic malignancy
- Patients with family history of lymphoma or hematologic cancers
- Individuals requiring diagnostic confirmation for treatment planning
Clinical Indications and Symptoms
The BCL2/IGH translocation is most commonly associated with follicular lymphoma, accounting for approximately 85-90% of cases. Patients experiencing persistent symptoms such as painless lymph node swelling, abdominal discomfort, chest pain, breathing difficulties, or recurrent infections should consider this testing for accurate diagnosis and appropriate management.
Benefits of BCL2/IGH t(14;18) Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous advantages:
- Definitive Diagnosis: Provides conclusive evidence for lymphoma classification
- Treatment Guidance: Helps oncologists develop targeted therapeutic strategies
- Prognostic Information: Offers insights into disease behavior and expected outcomes
- Monitoring Capability: Enables tracking of treatment response and disease progression
- Personalized Medicine: Supports individualized treatment approaches based on genetic profile
- Early Detection: Facilitates timely intervention and improved survival rates
Scientific Importance and Clinical Relevance
The BCL2/IGH translocation represents one of the most well-characterized genetic abnormalities in cancer biology. The resulting fusion gene leads to overexpression of the BCL2 protein, which normally functions as an anti-apoptotic factor. This overexpression prevents programmed cell death, allowing malignant B-cells to accumulate and form tumors. Understanding this mechanism has revolutionized lymphoma treatment and paved the way for targeted therapies.
Understanding Your Test Results
Interpreting BCL2/IGH t(14;18) test results requires professional medical expertise:
Positive Result Interpretation
- Confirms presence of t(14;18) translocation
- Strongly supports diagnosis of follicular lymphoma or related B-cell malignancy
- Provides valuable information for treatment planning and prognosis
- May indicate need for additional staging and monitoring
Negative Result Interpretation
- Absence of detectable t(14;18) translocation
- Does not completely rule out lymphoma diagnosis
- May suggest alternative lymphoma subtypes or genetic abnormalities
- Often requires additional diagnostic testing for comprehensive evaluation
Result Consultation
All test results should be discussed with your healthcare provider who can interpret the findings in the context of your complete clinical picture, including symptoms, physical examination findings, and other laboratory results.
Test Specifications and Pricing
| Test Parameter | Details |
|---|---|
| Test Name | BCL2/IGH t(14;18) FISH Test |
| Regular Price | $300 USD |
| Discount Price | $226 USD |
| Turnaround Time | 7-8 Days |
| Sample Type | Tumor Tissue |
| Test Components | Paraffin Embedded Tissue Blocks |
| Testing Method | Fluorescence In Situ Hybridization (FISH) |
| Medical Specialty | Oncology Genetics |
Pre-Test Instructions and Requirements
The BCL2/IGH t(14;18) test requires a physician’s prescription for proper medical supervision. Please note that prescription requirements do not apply to surgical cases, pregnancy-related testing, or individuals planning international travel. Our experienced medical team will guide you through the sample collection process and ensure proper handling of paraffin-embedded tissue blocks.
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and numerous other cities. Our extensive network ensures accessible genetic testing services for patients nationwide.
Why Choose Our Genetic Testing Services?
- Expertise in Molecular Oncology: Specialized focus on cancer genetics
- Advanced Technology: State-of-the-art FISH methodology
- Rapid Turnaround: Results within 7-8 business days
- Comprehensive Support: Professional genetic counseling available
- Insurance Coordination: Assistance with coverage verification
- Patient-Centered Care: Compassionate support throughout testing process
Take Control of Your Health Today
Don’t wait to get the answers you need for proper diagnosis and treatment. Our BCL2/IGH t(14;18) FISH test provides the critical genetic information necessary for effective lymphoma management. With our discounted price of $226 USD and rapid 7-8 day turnaround, you can access world-class genetic testing without delay.
Ready to Schedule Your Test?
Contact our dedicated patient care team today to schedule your BCL2/IGH t(14;18) genetic testing. Call us at +1(267) 388-9828 or book your appointment online. Our genetic specialists are available to answer your questions and guide you through the testing process with compassion and expertise.
Take the first step toward accurate diagnosis and personalized treatment – schedule your genetic test today!
