Anti-dsDNA Antibody Crithidia IFA Test: Comprehensive Diagnostic Solution
Understanding the Anti-dsDNA Antibody Crithidia IFA Test
The Anti-dsDNA Antibody Crithidia IFA Test represents a gold standard in autoimmune disease diagnostics, specifically designed to detect antibodies against double-stranded DNA (dsDNA). This sophisticated immunofluorescence assay utilizes Crithidia luciliae, a unique protozoan substrate that contains pure double-stranded DNA in its kinetoplast, providing exceptional specificity for lupus-related antibodies.
What This Test Measures and Detects
This specialized test specifically identifies IgG antibodies directed against native double-stranded DNA. Unlike other DNA antibody tests, the Crithidia IFA method offers superior specificity because:
- Detects antibodies exclusively against double-stranded DNA
- Uses Crithidia luciliae’s kinetoplast as natural substrate
- Provides highly specific results for systemic lupus erythematosus
- Measures antibody levels in precise dilutions for accurate quantification
Who Should Consider This Test?
This diagnostic test is particularly important for individuals experiencing symptoms suggestive of autoimmune disorders, especially systemic lupus erythematosus. Consider testing if you experience:
- Unexplained joint pain and swelling
- Persistent skin rashes, particularly butterfly rash across cheeks
- Chronic fatigue and unexplained fever
- Hair loss without clear cause
- Sensitivity to sunlight with skin reactions
- Mouth or nose ulcers
- Chest pain with deep breathing
- Kidney problems or abnormal urinalysis
- Neurological symptoms like seizures or confusion
Clinical Indications and Specialty Referrals
This test is commonly ordered by rheumatologists, dermatologists, and physicians specializing in autoimmune conditions. It serves as a crucial diagnostic tool for:
- Confirming systemic lupus erythematosus diagnosis
- Monitoring disease activity in established lupus patients
- Assessing risk of lupus nephritis and other organ involvement
- Differentiating lupus from other autoimmune conditions
- Evaluating patients with positive ANA tests
Benefits of Anti-dsDNA Antibody Testing
Choosing the Crithidia IFA method for anti-dsDNA antibody detection offers numerous advantages:
- High Specificity: Exceptional specificity for lupus diagnosis reduces false positives
- Disease Monitoring: Antibody levels often correlate with disease activity
- Early Detection: Enables early intervention and treatment planning
- Prognostic Value: Helps predict risk of kidney and other organ involvement
- Treatment Guidance: Assists in monitoring response to therapy
Understanding Your Test Results
Test results are reported in dilutions, with higher titers generally indicating more significant antibody presence:
- Negative Result: No detectable anti-dsDNA antibodies – suggests low probability of active lupus
- Low Positive: May indicate early disease or mild activity
- Moderate to High Positive: Strongly suggestive of active systemic lupus erythematosus
- Very High Titers: Often associated with increased risk of kidney involvement
Always discuss your results with your healthcare provider, as interpretation requires clinical correlation with symptoms and other laboratory findings.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $112 |
| Regular Price | $150 |
Test Specifications
- Turnaround Time: Sample collected daily by 11 am; Report available next day
- Sample Type: 3 mL (1.5 mL minimum) serum from 1 SST
- Shipping Requirements: Ship refrigerated or frozen
- Pre-test Instructions: Overnight fasting is preferred
- Testing Method: Immunofluorescence Assay (IFA)
- Department: Immunopathology
Nationwide Testing Availability
We have diagnostic centers conveniently located across the United States, serving major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, and many other cities. Our network ensures accessible, high-quality autoimmune testing for patients nationwide.
Take Control of Your Health Today
Don’t let unexplained symptoms compromise your quality of life. The Anti-dsDNA Antibody Crithidia IFA Test provides critical information for accurate diagnosis and effective management of autoimmune conditions. Our experienced team is ready to assist you with professional testing and comprehensive result interpretation.
Ready to schedule your test? Call or WhatsApp us today at +1(267) 388-9828 to book your appointment or discuss your testing needs with our healthcare specialists.
