AML PCR Panel (AML/ETO, inv(16), PML/RARA)
Comprehensive Genetic Testing for Acute Myeloid Leukemia
The AML PCR Panel represents a cutting-edge molecular diagnostic approach specifically designed for the detection and monitoring of Acute Myeloid Leukemia (AML). This sophisticated test utilizes Real-Time PCR technology to identify three critical genetic abnormalities that play pivotal roles in AML pathogenesis, classification, and treatment response prediction.
What Does the AML PCR Panel Detect?
This comprehensive panel targets three specific genetic markers essential for AML diagnosis and management:
- AML/ETO Fusion Gene: Resulting from t(8;21) translocation, this fusion gene creates a potent transcription factor that disrupts normal hematopoietic differentiation and promotes leukemogenesis.
- Inversion 16 (inv16): This chromosomal abnormality leads to the CBFB-MYH11 fusion gene, associated with acute myelomonocytic leukemia with eosinophilia and typically indicating favorable prognosis with appropriate treatment.
- PML/RARA Fusion Gene: Arising from t(15;17) translocation, this fusion characterizes acute promyelocytic leukemia (APL) and is particularly significant due to its responsiveness to targeted therapy with all-trans retinoic acid (ATRA).
Who Should Consider This Test?
The AML PCR Panel is recommended for individuals presenting with:
- Unexplained fatigue, weakness, or pallor
- Recurrent infections or fever without apparent cause
- Easy bruising, petechiae, or abnormal bleeding
- Bone pain or tenderness
- Unexplained weight loss or night sweats
- Abnormal complete blood count (CBC) results
- Suspected leukemia based on clinical presentation
- Monitoring treatment response in diagnosed AML patients
- Assessment of minimal residual disease (MRD) post-treatment
Clinical Benefits of AML PCR Testing
This advanced molecular panel offers numerous advantages for patients and healthcare providers:
- Accurate Diagnosis: Provides definitive genetic confirmation of specific AML subtypes
- Prognostic Information: Helps predict disease course and treatment response
- Treatment Guidance: Informs targeted therapy selection, particularly for APL cases
- Monitoring Capability: Enables sensitive detection of minimal residual disease
- Early Detection: Identifies genetic abnormalities before clinical manifestations become severe
- Personalized Medicine: Supports tailored treatment approaches based on genetic profile
Understanding Your Test Results
Your AML PCR Panel results will provide critical information about your genetic status:
- Positive Result: Indicates the presence of one or more targeted genetic abnormalities, confirming specific AML subtypes and guiding treatment decisions
- Negative Result: Suggests absence of the tested mutations, though other genetic abnormalities may still be present
- Quantitative Results: For monitoring purposes, the test can provide quantitative data to track disease burden over time
It’s essential to discuss your results with a qualified hematologist or oncologist who can interpret them in the context of your complete clinical picture and recommend appropriate management strategies.
Test Specifications and Pricing
| Test Component | Details |
|---|---|
| Test Name | AML PCR Panel (AML/ETO, inv(16), PML/RARA) |
| Regular Price | $276 USD |
| Discount Price | $206 USD |
| Turnaround Time | 5-6 days |
| Sample Type | Bone marrow / Peripheral blood (Transport immediately) |
| Test Components | EDTA Vacutainer (2ml) |
| Methodology | Real Time PCR |
Pre-Test Instructions
The AML PCR Panel requires a Doctor’s prescription for testing. Please note that prescription requirements do not apply for surgery and pregnancy cases or individuals planning to travel abroad. Our experienced staff will guide you through the sample collection process and ensure proper handling of your specimen for optimal test accuracy.
Nationwide Accessibility
We have branches conveniently located across the United States, serving major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our nationwide network ensures that quality genetic testing is accessible to patients throughout the country.
Take Action for Your Health
Early detection and accurate diagnosis are crucial for effective leukemia management. Don’t wait to get the answers you need. Our dedicated team is ready to assist you with scheduling, answer your questions, and provide the comprehensive genetic testing services you deserve.
Book your AML PCR Panel test today by calling or WhatsApp: +1(267) 388-9828
Take the first step toward understanding your genetic health and receiving the personalized care you need for optimal leukemia management and treatment outcomes.