ADGRG1 Gene Polymicrogyria Bilateral Frontoparietal NGS Genetic DNA Test
Comprehensive Genetic Testing for Brain Malformation Disorders
The ADGRG1 Gene Polymicrogyria Bilateral Frontoparietal NGS Genetic DNA Test represents a breakthrough in neurological genetic diagnostics, specifically designed to identify mutations in the ADGRG1 gene responsible for bilateral frontoparietal polymicrogyria (BFPP). This sophisticated genetic analysis provides critical insights into brain development abnormalities that can significantly impact neurological function and quality of life.
What is ADGRG1 Gene Polymicrogyria?
Bilateral frontoparietal polymicrogyria is a rare neurological condition characterized by abnormal development of the brain cortex, specifically affecting the frontal and parietal lobes. The condition results from mutations in the ADGRG1 gene, which plays a crucial role in brain development during fetal growth. This gene encodes a protein essential for proper neuronal migration and cortical organization, and when mutated, leads to the formation of excessive small folds (gyri) in the brain’s surface.
What Does This Test Detect?
Our advanced NGS (Next-Generation Sequencing) technology specifically targets and analyzes the ADGRG1 gene to identify:
- Point mutations and single nucleotide variants
- Small insertions and deletions
- Copy number variations affecting the ADGRG1 gene
- Pathogenic variants associated with BFPP
- Novel mutations not previously documented
The test provides comprehensive coverage of the entire ADGRG1 gene coding region, ensuring high detection rates for both known and novel mutations associated with this neurological condition.
Who Should Consider This Test?
Clinical Indications and Symptoms
This genetic test is recommended for individuals presenting with:
- Developmental delays in motor skills and speech
- Intellectual disability of varying severity
- Seizures or epilepsy beginning in childhood
- Motor coordination difficulties and ataxia
- Strabismus (crossed eyes) or other ocular abnormalities
- Dysarthria (speech articulation problems)
- Family history of similar neurological conditions
- Abnormal brain MRI showing polymicrogyria patterns
High-Risk Populations
- Children with unexplained developmental delays
- Individuals with family history of BFPP
- Patients with characteristic brain MRI findings
- Couples planning pregnancy with family history of neurological disorders
Benefits of ADGRG1 Genetic Testing
Comprehensive Diagnostic Advantages
- Definitive Diagnosis: Provides conclusive genetic confirmation of BFPP
- Early Intervention: Enables timely medical management and therapeutic interventions
- Family Planning: Offers crucial information for reproductive decision-making
- Prognostic Information: Helps predict disease progression and potential complications
- Personalized Care: Guides development of individualized treatment plans
- Genetic Counseling: Supports informed family discussions about inheritance patterns
Understanding Your Test Results
Result Interpretation Guidelines
Our comprehensive genetic report includes detailed analysis and interpretation:
- Positive Result: Indicates the presence of a pathogenic ADGRG1 mutation confirming BFPP diagnosis
- Negative Result: Suggests absence of detectable ADGRG1 mutations, though other genetic causes should be considered
- Variant of Uncertain Significance: Identifies genetic changes requiring further clinical correlation
- Carrier Status: Determines if individuals carry one copy of the mutated gene
All results are accompanied by detailed explanations and recommendations for next steps, including referral to appropriate specialists and genetic counseling services.
Test Details and Pricing
| Test Component | Details | Price (USD) |
|---|---|---|
| Test Name | ADGRG1 Gene Polymicrogyria Bilateral Frontoparietal NGS Genetic DNA Test | – |
| Discount Price | Special promotional rate | $500 |
| Regular Price | Standard testing fee | $700 |
| Turnaround Time | Comprehensive analysis period | 3-4 Weeks |
| Sample Type | Required specimen | Blood |
| Testing Method | Advanced technology used | NGS Technology |
Pre-Test Requirements
Essential Preparation Steps
- Complete clinical history documentation of the patient
- Genetic counseling session to create detailed family pedigree
- Review of any previous neurological evaluations or brain imaging
- Discussion of testing implications and potential outcomes
- Informed consent process for genetic testing
Nationwide Testing Availability
We have conveniently located testing centers across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, Charlotte, San Francisco, Indianapolis, Seattle, Denver, Washington DC, Boston, El Paso, Nashville, Detroit, Oklahoma City, Portland, Las Vegas, Memphis, Louisville, Baltimore, and Milwaukee.
Take Control of Your Genetic Health Today
Don’t let uncertainty about neurological conditions affect your family’s future. Our ADGRG1 Gene Polymicrogyria Bilateral Frontoparietal NGS Genetic DNA Test provides the answers you need for informed medical decisions and comprehensive care planning.
Call or WhatsApp us now at +1(267) 388-9828 to schedule your genetic test consultation and take the first step toward definitive diagnosis and personalized treatment.
Our dedicated genetic specialists are available to answer your questions, discuss testing options, and help you understand the benefits of comprehensive genetic analysis for neurological conditions. Early detection through advanced genetic testing can make a significant difference in management outcomes and quality of life.
