ACTN4 Gene Focal Segmental Glomerulosclerosis Type 1 NGS Genetic DNA Test
Comprehensive Genetic Testing for Hereditary Kidney Disease
The ACTN4 Gene Focal Segmental Glomerulosclerosis Type 1 NGS Genetic DNA Test represents a breakthrough in precision medicine for kidney health. This advanced diagnostic tool specifically targets mutations in the ACTN4 gene, which encodes alpha-actinin-4, a crucial protein involved in maintaining the structural integrity of kidney podocytes. When this gene malfunctions, it leads to progressive kidney damage characteristic of focal segmental glomerulosclerosis (FSGS) type 1.
What This Test Measures and Detects
Our comprehensive NGS-based genetic analysis examines the entire coding region of the ACTN4 gene to identify:
- Pathogenic mutations associated with autosomal dominant FSGS
- Missense variants affecting alpha-actinin-4 protein function
- Genetic alterations impacting podocyte cytoskeletal organization
- Inherited mutations causing progressive glomerular scarring
- Specific genetic markers for early-onset kidney disease
The test utilizes state-of-the-art Next-Generation Sequencing technology, providing unparalleled accuracy in detecting even rare genetic variants that conventional methods might miss.
Who Should Consider This Genetic Test
This specialized genetic test is recommended for individuals experiencing:
- Unexplained proteinuria or nephrotic syndrome
- Family history of FSGS or hereditary kidney disease
- Early-onset renal dysfunction without clear cause
- Resistant hypertension with kidney involvement
- Progressive decline in kidney function
- Children or young adults with steroid-resistant nephrotic syndrome
- Individuals with multiple family members affected by kidney failure
Significant Benefits of Genetic Testing
Undergoing the ACTN4 Gene FSGS Type 1 test provides numerous advantages:
- Early Intervention: Identify genetic predisposition before significant kidney damage occurs
- Personalized Treatment: Guide medication choices and therapeutic approaches based on genetic profile
- Family Planning: Make informed decisions about genetic inheritance risks
- Proactive Monitoring: Implement targeted surveillance for at-risk family members
- Accurate Diagnosis: Differentiate between genetic and acquired forms of FSGS
- Improved Outcomes: Enable timely interventions to preserve kidney function
Understanding Your Test Results
Our comprehensive genetic counseling service helps you interpret your results:
- Positive Result: Indicates presence of ACTN4 gene mutation associated with FSGS type 1. Our genetic counselors will explain inheritance patterns and recommend appropriate monitoring and management strategies.
- Negative Result: Suggests absence of tested ACTN4 mutations. However, other genetic or environmental factors may still contribute to kidney disease.
- Variant of Uncertain Significance: Some genetic changes require additional research. We provide ongoing support as scientific understanding evolves.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
| Turnaround Time | 3-4 Weeks |
| Sample Type | Blood |
Nationwide Testing Availability
We have conveniently located testing centers across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network ensures accessible genetic testing services regardless of your location.
Take Control of Your Kidney Health Today
Don’t wait for symptoms to progress. Early genetic detection of ACTN4 mutations can significantly impact your kidney health management and treatment outcomes. Our team of genetic specialists, nephrologists, and counselors are ready to support you through every step of the testing process.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your ACTN4 Gene FSGS Type 1 NGS Genetic DNA Test. Take the first step toward personalized kidney health management and peace of mind.
