Activated Protein C Resistance (APCR) Test
Understanding Activated Protein C Resistance Testing
The Activated Protein C Resistance (APCR) Test represents a cornerstone in modern hematological diagnostics, specifically designed to evaluate your body’s natural anticoagulant mechanisms. This sophisticated laboratory analysis examines how effectively your blood responds to activated protein C, a critical regulatory protein that prevents excessive clot formation. When this delicate balance is disrupted, it can lead to thrombophilia—a condition characterized by increased susceptibility to abnormal blood clotting.
What Does the APCR Test Measure?
The APCR test precisely quantifies your blood’s resistance to the anticoagulant effects of activated protein C. This protein normally functions by inactivating clotting factors Va and VIIIa, thereby regulating the coagulation cascade. The test measures:
- Blood clotting time in the presence of activated protein C
- Comparison with baseline clotting time without activated protein C
- The ratio that indicates resistance levels
- Potential Factor V Leiden mutation presence
Who Should Consider APCR Testing?
This specialized test is recommended for individuals experiencing specific clinical scenarios or having particular risk factors:
Clinical Indications
- Personal history of unexplained blood clots (venous thromboembolism)
- Family history of thrombophilia or clotting disorders
- Recurrent pregnancy loss or complications
- Unexplained arterial thrombosis in young patients
- Prior to major surgical procedures with high thrombosis risk
- Women considering hormonal contraception or hormone replacement therapy
- Patients with unusual clot locations (cerebral, mesenteric, portal veins)
Symptoms Warranting Evaluation
- Swelling, pain, or redness in limbs suggesting deep vein thrombosis
- Chest pain, shortness of breath, or coughing blood indicating pulmonary embolism
- Multiple unexplained miscarriages
- Family members diagnosed with hereditary thrombophilia
- Clotting events without typical risk factors
Benefits of APCR Testing
Undergoing APCR testing provides numerous advantages for comprehensive healthcare management:
Early Risk Identification
Detecting activated protein C resistance allows for proactive management strategies before serious clotting events occur. This early identification can prevent life-threatening conditions like pulmonary embolism and stroke.
Personalized Treatment Planning
Test results guide healthcare providers in developing tailored anticoagulation regimens, determining appropriate medication dosages, and establishing optimal monitoring schedules.
Informed Family Planning
For women of childbearing age, understanding thrombophilia risk enables better pregnancy management and reduces complications like recurrent miscarriage or placental insufficiency.
Surgical Safety Enhancement
Pre-operative APCR testing helps surgeons implement appropriate thromboprophylaxis measures, significantly reducing post-operative clotting risks.
Understanding Your Test Results
Normal Results
A normal APCR ratio indicates that your blood responds appropriately to activated protein C, suggesting typical anticoagulant function and lower thrombosis risk.
Abnormal Results Interpretation
- Mild Resistance: May indicate heterozygous Factor V Leiden mutation or other mild thrombophilia factors
- Significant Resistance: Often suggests homozygous Factor V Leiden mutation or severe thrombophilia
- Acquired Resistance: Can result from pregnancy, oral contraceptive use, or certain medical conditions
Next Steps After Testing
Your hematologist will interpret results in context with your clinical history and may recommend:
- Additional confirmatory testing if indicated
- Lifestyle modifications to reduce thrombosis risk
- Prophylactic anticoagulation during high-risk periods
- Regular monitoring and follow-up testing
- Family member screening when hereditary factors are identified
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Activated Protein C Resistance (APCR) Test | $130 USD | $188 USD |
Turnaround Time
Sample collected by Wednesday 11:00 AM | Report delivered next day
Sample Requirements
3 mL whole blood in 1 Blue Top (Sodium Citrate) tube. Proper mixing by inversion is essential. Transport to laboratory within 4 hours. If immediate transport isn’t possible, platelet-poor plasma preparation within 1 hour of collection is required with specific centrifugation protocols. Overnight fasting is preferred for optimal results.
Pre-Test Instructions
Complete Coagulation Requisition Form (Form 15) is mandatory. Consultation with your physician regarding temporary discontinuation of heparin (1 day) and oral anticoagulants (7 days) prior to sampling is recommended, as these medications may affect test accuracy.
Nationwide Testing Availability
We maintain comprehensive testing facilities across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and numerous other cities. Our network ensures accessible, reliable APCR testing regardless of your location.
Book Your APCR Test Today
Take control of your clotting health with our comprehensive Activated Protein C Resistance testing. Our state-of-the-art laboratories utilize advanced electromechanical clot detection methodology to deliver accurate, reliable results. With rapid turnaround times and expert hematological interpretation, you’ll receive the insights needed for informed healthcare decisions.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your APCR test appointment. Our knowledgeable staff will guide you through the testing process, answer your questions, and ensure you receive the highest quality diagnostic care.
Early detection of thrombophilia through APCR testing can be life-saving. Don’t wait—take the first step toward understanding your clotting risk profile and protecting your long-term health.
