Immunohistochemistry STAT6 Test
Understanding the Immunohistochemistry STAT6 Test
The Immunohistochemistry STAT6 Test represents a cutting-edge diagnostic approach in modern pathology and oncology. This specialized laboratory procedure utilizes advanced immunohistochemical techniques to detect the presence and distribution of the STAT6 protein within tissue samples. STAT6 (Signal Transducer and Activator of Transcription 6) serves as a crucial biomarker that plays significant roles in cellular signaling pathways and has emerged as an essential diagnostic tool for identifying specific tumor types, particularly solitary fibrous tumors.
Scientific Foundation and Clinical Importance
Immunohistochemistry (IHC) represents a sophisticated laboratory technique that enables pathologists to visualize specific proteins within tissue sections. The STAT6 protein functions as a transcription factor involved in interleukin-4 and interleukin-13 signaling pathways. When this protein becomes overexpressed or shows abnormal patterns in tumor cells, it provides valuable diagnostic information that helps distinguish between different types of soft tissue tumors and guides appropriate treatment decisions.
What the STAT6 Test Detects and Measures
The Immunohistochemistry STAT6 Test specifically identifies and measures:
- Presence and intensity of STAT6 protein expression in tumor cells
- Nuclear localization patterns of STAT6 protein
- Distribution of STAT6 across different tissue compartments
- Expression levels that help differentiate tumor types
- Cellular patterns indicative of specific genetic alterations
Primary Diagnostic Applications
This test is particularly valuable for diagnosing solitary fibrous tumors (SFTs), which are mesenchymal tumors that can occur in various anatomical locations. The detection of nuclear STAT6 expression has become a highly sensitive and specific marker for identifying these tumors, helping pathologists distinguish them from other spindle cell neoplasms that may have similar histological appearances but require different treatment approaches.
Who Should Consider the STAT6 Test
This diagnostic test is recommended for patients presenting with:
- Suspicious soft tissue masses requiring precise classification
- Previously diagnosed tumors needing further characterization
- Cases where solitary fibrous tumor is suspected based on imaging or initial pathology
- Patients with spindle cell neoplasms requiring differential diagnosis
- Individuals with recurrent tumors needing confirmation of diagnosis
- Cases where treatment planning depends on accurate tumor classification
Clinical Indications and Symptoms
Patients typically present with palpable masses, abnormal imaging findings, or symptoms related to tumor location and size. The STAT6 test becomes particularly important when conventional histological examination cannot definitively classify the tumor type, or when specific targeted therapies might be indicated based on the molecular characteristics of the tumor.
Benefits of the Immunohistochemistry STAT6 Test
Choosing the STAT6 test provides numerous clinical advantages:
- Accurate Diagnosis: Enables precise identification of solitary fibrous tumors and differentiation from similar-looking tumors
- Treatment Guidance: Helps oncologists develop targeted treatment strategies based on specific tumor characteristics
- Prognostic Information: Provides insights into tumor behavior and potential clinical outcomes
- Minimized Misdiagnosis: Reduces the risk of incorrect tumor classification that could lead to inappropriate treatments
- Personalized Medicine: Supports the development of individualized treatment plans based on molecular markers
- Comprehensive Assessment: Complements other diagnostic modalities for a complete clinical picture
Understanding Your Test Results
Interpreting STAT6 test results requires specialized pathological expertise:
Positive STAT6 Expression
A positive result typically shows strong nuclear staining for STAT6 in tumor cells. This finding strongly supports the diagnosis of solitary fibrous tumor and helps distinguish it from histological mimics. The intensity and distribution of staining provide additional information about the tumor’s characteristics.
Negative STAT6 Expression
Absence of STAT6 nuclear staining suggests alternative diagnoses and helps exclude solitary fibrous tumor from consideration. Your pathologist will correlate these findings with other histological features and potentially recommend additional testing to establish a definitive diagnosis.
Clinical Correlation
It’s essential to understand that test results must be interpreted in the context of clinical presentation, imaging findings, and other pathological features. Your healthcare provider will explain how these results impact your diagnosis and treatment plan.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $88 |
| Regular Price | $112 |
Turnaround Time and Sample Requirements
Our laboratory maintains efficient processing with the following turnaround times:
- Sample Submission: Daily by 6 PM
- Block Samples: 5 days
- Tissue Biopsy: 5 days
- Large Complex Tissue: 7 days
Sample Collection and Preparation
For optimal results, please provide:
- Tumor tissue preserved in 10% formal-saline OR formalin-fixed paraffin-embedded block
- Ship samples at room temperature with appropriate packaging
- Include complete clinical documentation including histopathology report
- Provide biopsy site information and detailed clinical history
- Submit a copy of the original histopathology report
Nationwide Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and numerous other cities. Our network of certified laboratories ensures consistent quality and reliable results nationwide.
Take Control of Your Health Today
Don’t leave your diagnosis to chance. The Immunohistochemistry STAT6 Test provides the clarity and precision needed for accurate cancer diagnosis and effective treatment planning. Our team of experienced pathologists and laboratory specialists are committed to delivering reliable results that your healthcare team can trust.
Ready to Schedule Your Test?
Contact us today to book your Immunohistochemistry STAT6 Test and take the first step toward precise diagnosis and personalized treatment. Our patient care coordinators are available to answer your questions and guide you through the testing process.
Call or WhatsApp: +1(267) 388-9828
Schedule your appointment now and benefit from our specialized expertise in cancer diagnostics. Early and accurate diagnosis can make all the difference in your treatment journey.
