Immunohistochemistry SOX11 Test: Advanced Cancer Diagnosis and Classification
Understanding the Immunohistochemistry SOX11 Test
The Immunohistochemistry SOX11 Test represents a cutting-edge diagnostic approach in modern oncology, specifically designed to detect the presence of SOX11 protein expression in tissue specimens. This specialized immunohistochemical analysis plays a pivotal role in cancer diagnosis, particularly in the classification of hematologic malignancies and solid tumors. SOX11 (SRY-related HMG-box 11) is a transcription factor that serves as a crucial biomarker for identifying specific cancer subtypes, with significant implications for treatment planning and prognostic assessment.
This sophisticated diagnostic tool utilizes advanced immunohistochemistry techniques to visualize SOX11 protein localization within tissue samples, providing pathologists with essential information about tumor characteristics and behavior. The test’s precision and reliability make it an indispensable component of comprehensive cancer evaluation protocols, enabling healthcare providers to make informed decisions about patient management strategies.
What the SOX11 Test Measures and Detects
The Immunohistochemistry SOX11 Test specifically measures the expression levels and cellular localization of the SOX11 protein within tumor tissue samples. This biomarker detection provides critical diagnostic information for:
- Identification of mantle cell lymphoma (MCL) and its differentiation from other B-cell lymphomas
- Detection of SOX11-positive tumor cells in various hematologic malignancies
- Assessment of tumor aggressiveness and proliferation patterns
- Evaluation of nuclear staining patterns that indicate SOX11 protein expression
- Classification of ambiguous lymphoid proliferations and lymphomas
The test employs specific antibodies that bind to SOX11 proteins, creating visible staining patterns that pathologists can interpret to determine the presence and intensity of SOX11 expression. This molecular profiling helps distinguish between different lymphoma subtypes that may appear similar under conventional microscopic examination.
Who Should Consider SOX11 Testing
SOX11 immunohistochemistry testing is particularly valuable for patients presenting with specific clinical scenarios and symptoms:
Clinical Indications Include:
- Patients with suspected or diagnosed lymphoma requiring precise classification
- Individuals with B-cell lymphoproliferative disorders showing ambiguous features
- Cases where mantle cell lymphoma is in the differential diagnosis
- Patients with lymphadenopathy or organomegaly of unknown origin
- Individuals requiring prognostic stratification for treatment planning
- Cases with atypical lymphoid infiltrates in tissue biopsies
Symptoms That May Warrant Testing:
- Persistent swollen lymph nodes
- Unexplained weight loss and fatigue
- Night sweats and fever without infection
- Abdominal discomfort or fullness
- Skin rashes or lesions in lymphoma cases
- Generalized itching without apparent cause
Benefits of SOX11 Immunohistochemistry Testing
Undergoing SOX11 testing provides numerous advantages for both patients and healthcare providers:
- Precise Diagnosis: Enables accurate classification of lymphoma subtypes, particularly distinguishing mantle cell lymphoma from other B-cell neoplasms
- Treatment Guidance: Results directly influence therapeutic decisions, including the selection of targeted therapies and chemotherapy regimens
- Prognostic Information: SOX11 expression patterns provide valuable insights into disease behavior and expected outcomes
- Minimized Misdiagnosis: Reduces the risk of incorrect lymphoma classification that could lead to inappropriate treatment
- Comprehensive Assessment: Complements other diagnostic modalities to provide a complete picture of the disease
- Monitoring Capability: Can be used to assess treatment response and disease progression in follow-up evaluations
Understanding Your SOX11 Test Results
Interpreting SOX11 immunohistochemistry results requires specialized expertise, but general guidance can help patients understand their reports:
Positive SOX11 Expression:
- Typically indicates the presence of SOX11-positive tumor cells
- Strongly supports the diagnosis of mantle cell lymphoma in appropriate clinical contexts
- May suggest specific biological behavior and treatment responsiveness
- Requires correlation with other clinical and pathological findings
Negative SOX11 Expression:
- Suggests the absence of significant SOX11 protein in the tested tissue
- May help exclude certain lymphoma subtypes from consideration
- Should be interpreted in the context of the complete diagnostic picture
- Does not necessarily rule out all malignancies, as some tumors may not express SOX11
Interpretation Considerations:
- Results should always be reviewed by an experienced hematopathologist
- Clinical correlation with patient symptoms and other test results is essential
- Pattern and intensity of staining provide additional diagnostic information
- Technical factors and sample quality can influence test interpretation
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| Immunohistochemistry SOX11 Test – Discount Price | $88 |
| Immunohistochemistry SOX11 Test – Regular Price | $112 |
Nationwide Testing Availability
General Genetics Corporation provides comprehensive SOX11 testing services across the United States, with convenient locations in all major metropolitan areas. Our network includes specialized testing facilities in:
- New York City and surrounding tri-state area
- Los Angeles and Southern California region
- Chicago and Midwest locations
- Houston, Dallas, and Texas facilities
- Phoenix, Arizona diagnostic centers
- Philadelphia and East Coast locations
- All other major US cities and regions
Sample Requirements and Turnaround Time
For optimal SOX11 testing results, please ensure proper sample collection and submission:
Sample Type:
- Submit tumor tissue in 10% formal-saline OR formalin fixed paraffin embedded block
- Ship samples at room temperature with appropriate packaging
- Include complete clinical documentation
Required Documentation:
- Copy of the histopathology report
- Site of biopsy specification
- Detailed clinical history
Turnaround Times:
- Sample acceptance: Daily by 6 PM
- Block processing: 5 days
- Tissue biopsy analysis: 5 days
- Large complex tissue specimens: 7 days
Take Action for Your Health Today
Don’t leave your cancer diagnosis to chance. The Immunohistochemistry SOX11 Test provides the precise information needed for accurate diagnosis and effective treatment planning. Our specialized oncology team is ready to assist you with comprehensive testing and expert interpretation.
Book your Immunohistochemistry SOX11 Test today by calling our dedicated healthcare line at +1(267) 388-9828 or schedule your appointment online. Take the first step toward precise cancer diagnosis and personalized treatment guidance with our advanced SOX11 testing services.
Our experienced medical professionals are available to answer your questions, discuss testing options, and guide you through the diagnostic process. With convenient locations nationwide and competitive pricing at only $88 USD, there’s no reason to delay this essential diagnostic evaluation.
