Immunohistochemistry INI1 Test: Advanced Cancer Diagnosis
Understanding the INI1 Immunohistochemistry Test
The Immunohistochemistry INI1 Test represents a cutting-edge diagnostic approach in modern oncology, specifically designed to detect the presence or absence of the INI1 protein in tumor tissues. This protein, also known as SMARCB1, functions as a crucial tumor suppressor that regulates cell growth and division. When INI1 expression is lost, it indicates specific types of aggressive cancers that require specialized treatment approaches.
This test utilizes advanced immunohistochemistry techniques, where specific antibodies bind to the INI1 protein in tissue samples. The resulting staining patterns provide pathologists with visual evidence of protein expression levels, enabling precise cancer classification and informing critical treatment decisions for patients facing complex tumor diagnoses.
What the INI1 Test Detects and Measures
The Immunohistochemistry INI1 Test specifically measures:
- Presence or absence of INI1 protein expression in tumor cells
- Nuclear staining patterns indicating normal INI1 function
- Loss of INI1 expression characteristic of specific tumor types
- Protein localization within cell nuclei
- Staining intensity and distribution patterns
This test is particularly valuable for identifying tumors with INI1 deficiency, which includes malignant rhabdoid tumors, epithelioid sarcomas, renal medullary carcinomas, and certain central nervous system tumors. The detection of INI1 loss helps distinguish these aggressive cancers from other tumor types with similar histological appearances.
Who Should Consider INI1 Testing
Clinical Indications and Symptoms
Patients who may benefit from INI1 Immunohistochemistry testing include those with:
- Suspected malignant rhabdoid tumors in children or adults
- Epithelioid sarcoma diagnoses requiring confirmation
- Renal medullary carcinoma presentations
- Atypical teratoid/rhabdoid tumors of the central nervous system
- Poorly differentiated tumors with rhabdoid features
- Complex sarcomas requiring precise classification
- Recurrent tumors needing molecular characterization
Oncologists and pathologists typically recommend this test when standard histological examination reveals ambiguous features or when specific clinical presentations suggest INI1-deficient tumors. Early testing can significantly impact treatment planning and prognostic assessment.
Benefits of INI1 Immunohistochemistry Testing
Undergoing INI1 testing provides numerous clinical advantages:
- Accurate Diagnosis: Precisely identifies INI1-deficient tumors for targeted treatment
- Treatment Guidance: Informs chemotherapy and radiation therapy decisions
- Prognostic Information: Helps predict disease course and outcomes
- Therapeutic Targeting: Identifies patients who may benefit from specific molecular therapies
- Differential Diagnosis: Distinguishes between similar-appearing tumor types
- Clinical Trial Eligibility: Determines suitability for targeted therapy trials
Understanding Your INI1 Test Results
Interpretation Guidelines
Your INI1 Immunohistochemistry results will typically show one of two patterns:
Normal INI1 Expression
Positive nuclear staining in tumor cells indicates preserved INI1 protein expression. This result suggests that the tumor is not among the specific INI1-deficient types and may require alternative diagnostic approaches.
Loss of INI1 Expression
Absent nuclear staining in tumor cells while surrounding normal tissue shows positive staining indicates INI1 deficiency. This pattern strongly supports diagnoses such as malignant rhabdoid tumor, epithelioid sarcoma, or other INI1-deficient neoplasms.
Important: Always discuss your results with your oncologist or pathologist, who will interpret them in the context of your complete clinical picture, including imaging studies, symptoms, and other laboratory findings.
Test Pricing and Availability
| Test Description | Regular Price | Discount Price |
|---|---|---|
| Immunohistochemistry INI1 Test | $126 USD | $88 USD |
Turnaround Time
- Block Samples: 5 days
- Tissue Biopsy: 5 days
- Large Complex Tissue: 7 days
- Sample Submission: Daily by 6 PM
Sample Requirements and Preparation
Sample Type
Submit tumor tissue in 10% formal-saline OR formalin-fixed paraffin-embedded block. Ship at room temperature.
Required Documentation
- Copy of the Histopathology report
- Site of biopsy information
- Complete clinical history
Nationwide Testing Availability
GGC DNA provides comprehensive INI1 Immunohistochemistry testing services across the United States. We have established branches in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and numerous other cities. Our nationwide network ensures accessible, reliable testing for patients and healthcare providers throughout the country.
Book Your INI1 Test Today
Take the next step in your diagnostic journey with confidence. Our specialized team at GGC DNA is ready to provide you with accurate, timely INI1 testing results that can make a significant difference in your cancer care.
Call or WhatsApp us today: +1(267) 388-9828
Schedule your Immunohistochemistry INI1 Test and gain the critical diagnostic information needed for informed treatment decisions. Our experienced pathology team and state-of-the-art laboratory facilities ensure the highest quality testing standards and reliable results you can trust.
