Immunohistochemistry CD19 Test: Advanced B-Cell Cancer Detection
Understanding the Immunohistochemistry CD19 Test
The Immunohistochemistry CD19 Test represents a cornerstone in modern cancer diagnostics, specifically designed to detect the presence of CD19 antigens on cell surfaces. CD19 is a critical B-cell marker expressed throughout B-cell development, making this test invaluable for identifying B-cell lineage malignancies. This sophisticated diagnostic approach utilizes specific antibodies that bind to CD19 proteins, allowing pathologists to visualize and quantify B-cell populations within tissue samples with exceptional precision.
As a specialized immunohistochemical procedure, this test plays a pivotal role in distinguishing between different types of lymphomas and leukemias, providing clinicians with essential information for accurate diagnosis and treatment planning. The test’s ability to confirm B-cell origin in malignant cells makes it particularly crucial for hematological malignancies where precise lineage determination directly impacts therapeutic decisions and patient outcomes.
What the CD19 Test Measures and Detects
The Immunohistochemistry CD19 Test specifically measures the expression of CD19 glycoprotein, a member of the immunoglobulin superfamily that serves as a reliable marker for B-cells at various stages of development. This test detects:
- Presence and distribution of CD19-positive B-cells in tissue samples
- B-cell lineage confirmation in suspected lymphomas and leukemias
- Patterns of CD19 expression that help differentiate between benign and malignant B-cell populations
- Intensity and localization of CD19 staining within tissue architecture
- Co-expression patterns with other B-cell markers for comprehensive profiling
This detailed analysis enables pathologists to identify abnormal B-cell proliferation patterns characteristic of various hematological malignancies, including diffuse large B-cell lymphoma, follicular lymphoma, chronic lymphocytic leukemia, and other B-cell neoplasms.
Who Should Consider the CD19 Test
The Immunohistochemistry CD19 Test is recommended for patients presenting with symptoms or clinical findings suggestive of B-cell malignancies. Consider this essential diagnostic test if you experience:
- Unexplained, persistent lymph node enlargement or swelling
- Unexplained fever, night sweats, or weight loss (B symptoms)
- Persistent fatigue and weakness without clear cause
- Abnormal blood counts suggesting hematological disorders
- Enlarged spleen or liver detected during physical examination
- Previous diagnosis requiring confirmation of B-cell lineage
- Monitoring treatment response in known B-cell malignancies
- Suspected lymphoma based on imaging studies or clinical presentation
Clinical Benefits of CD19 Testing
Undergoing the Immunohistochemistry CD19 Test provides numerous clinical advantages for accurate diagnosis and effective treatment planning:
- Precise Diagnosis: Confirms B-cell origin of malignant cells, enabling accurate classification of lymphomas and leukemias
- Treatment Guidance: Helps oncologists select appropriate targeted therapies, including monoclonal antibodies and CAR-T cell therapies
- Prognostic Information: Provides valuable insights into disease behavior and potential treatment responses
- Minimal Tissue Requirement: Can be performed on small biopsy samples, reducing the need for additional invasive procedures
- Comprehensive Analysis: Can be combined with other immunohistochemical markers for complete immunophenotyping
- Therapeutic Monitoring: Assists in evaluating treatment effectiveness and detecting residual disease
Understanding Your CD19 Test Results
Interpreting Immunohistochemistry CD19 Test results requires specialized expertise from our board-certified pathologists. Here’s general guidance on understanding your results:
Positive CD19 Expression
A positive result indicates the presence of CD19 markers on cell surfaces, confirming B-cell lineage. The pattern, intensity, and distribution of staining provide additional diagnostic information:
- Strong, diffuse staining: Typically indicates mature B-cell malignancies
- Variable intensity: May suggest different stages of B-cell development or heterogeneous tumor populations
- Specific localization: Membrane staining confirms surface expression, while cytoplasmic staining may indicate intracellular accumulation
Negative CD19 Expression
Absence of CD19 staining suggests the cells are not of B-cell origin, which helps exclude B-cell malignancies and directs further diagnostic evaluation toward other cell lineages.
Interpretation Context
Your results will be interpreted in the context of clinical history, other laboratory findings, and additional immunohistochemical markers. Our expert pathologists provide comprehensive reports with detailed explanations and clinical correlations to ensure you and your healthcare provider have all necessary information for informed decision-making.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Immunohistochemistry CD19 Test | $88 USD | $126 USD |
Nationwide Availability and Convenient Testing
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas. Our state-of-the-art facilities in New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose ensure accessible, high-quality diagnostic services for everyone.
Sample Requirements and Turnaround Time
For optimal results, please provide:
- Tumor tissue preserved in 10% formal-saline OR formalin-fixed paraffin-embedded block
- Ship samples at room temperature with proper packaging
- Include a copy of the histopathology report, biopsy site information, and complete clinical history
Turnaround Times:
- Blocks: 5 days
- Tissue Biopsy: 5 days
- Tissue Large Complex: 7 days
- Samples accepted daily by 6 PM
Take Control of Your Health Today
Don’t wait to get the answers you need for proper diagnosis and treatment. The Immunohistochemistry CD19 Test provides critical information that can significantly impact your healthcare journey. Our experienced team is ready to assist you with convenient scheduling, expert sample processing, and comprehensive result interpretation.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your Immunohistochemistry CD19 Test and take the first step toward accurate diagnosis and effective treatment planning.
Our dedicated customer service representatives are available to answer your questions, explain the testing process, and help you coordinate sample collection and delivery. Trust General Genetics Corporation for reliable, accurate, and timely cancer diagnostics that put your health first.
