Immunohistochemistry ATRX Test: Advanced Cancer Diagnosis
Understanding the Immunohistochemistry ATRX Test
The Immunohistochemistry ATRX Test represents a cutting-edge diagnostic approach in modern oncology, specifically designed to evaluate ATRX (Alpha Thalassemia/Mental Retardation Syndrome X-Linked) protein expression in tumor tissues. This sophisticated laboratory technique utilizes specific antibodies to detect the presence or absence of ATRX protein within cancer cells, providing crucial information for accurate tumor classification and treatment planning.
ATRX is a chromatin remodeling protein that plays a vital role in maintaining genomic stability and regulating gene expression. When mutations occur in the ATRX gene, it can lead to loss of protein expression, which has significant implications for tumor behavior and patient outcomes. The Immunohistochemistry ATRX Test serves as an essential tool for oncologists and pathologists in characterizing central nervous system tumors and guiding personalized treatment approaches.
What Does the ATRX Test Measure and Detect?
The Immunohistochemistry ATRX Test specifically measures:
- Presence or absence of ATRX protein expression in tumor nuclei
- Nuclear staining patterns that indicate functional ATRX protein
- Loss of ATRX expression, which correlates with specific genetic mutations
- Tumor cell characteristics that help classify glioma subtypes
This test detects abnormalities in ATRX protein expression that are characteristic of certain brain tumors, particularly diffuse gliomas. The absence of ATRX nuclear staining typically indicates ATRX gene mutations, which are commonly associated with specific molecular subtypes of gliomas and can influence treatment response and prognosis.
Who Should Consider the Immunohistochemistry ATRX Test?
Clinical Indications and Symptoms
This test is recommended for patients experiencing:
- Neurological symptoms suggesting brain tumors (headaches, seizures, vision changes)
- Recently diagnosed brain masses requiring precise classification
- Suspected glioma or astrocytoma based on imaging studies
- Recurrent brain tumors needing molecular characterization
- Patients with family history of cancer syndromes
- Individuals with unexplained neurological deterioration
Medical Conditions That Benefit from ATRX Testing
- Diffuse astrocytomas and oligodendrogliomas
- Glioblastoma multiforme cases requiring molecular subtyping
- Pediatric high-grade gliomas
- Secondary glioblastomas
- Cases where IDH mutation status needs correlation
Benefits of Taking the Immunohistochemistry ATRX Test
Undergoing the Immunohistochemistry ATRX Test provides numerous advantages for both patients and healthcare providers:
Diagnostic Precision
- Enables accurate classification of glioma subtypes
- Helps distinguish between different types of brain tumors
- Provides complementary information to genetic testing
- Supports integrated diagnosis combining histology and molecular features
Treatment Guidance
- Informs selection of appropriate treatment strategies
- Helps predict response to certain therapies
- Guides decisions regarding surgical intervention
- Assists in determining prognosis and survival expectations
Clinical Management Advantages
- Facilitates personalized medicine approaches
- Supports enrollment in clinical trials when appropriate
- Provides basis for long-term monitoring strategies
- Helps family members understand genetic implications
Understanding Your Test Results
Interpretation Guidelines
Your Immunohistochemistry ATRX Test results will typically show one of the following patterns:
ATRX Protein Retained
Normal nuclear staining pattern indicates preserved ATRX protein expression. This result suggests the absence of ATRX gene mutations and may be associated with certain glioma subtypes that have different clinical behaviors and treatment responses.
ATRX Protein Lost
Absence of nuclear staining indicates loss of ATRX protein expression, typically due to ATRX gene mutations. This finding is commonly associated with specific molecular subtypes of gliomas and may influence treatment decisions and prognosis estimates.
Clinical Correlation
It’s essential to understand that ATRX test results should always be interpreted in the context of:
- Other molecular markers (IDH, 1p/19q status)
- Histopathological features
- Clinical presentation and imaging findings
- Patient’s overall health status
Your healthcare provider will integrate these results with other diagnostic information to develop a comprehensive understanding of your condition and create an appropriate treatment plan.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $88 |
| Regular Price | $140 |
Turnaround Time
- Sample Daily by 6 pm
- Report Block: 5 days
- Tissue Biopsy: 5 days
- Tissue large complex: 7 days
Sample Requirements
Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block. Ship at room temperature. Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Nationwide Availability Across USA
We have diagnostic centers conveniently located throughout the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures accessible, high-quality diagnostic services no matter where you are located.
Take Action Today for Better Health Outcomes
Don’t delay in obtaining the critical diagnostic information you need for proper cancer management. The Immunohistochemistry ATRX Test provides essential molecular insights that can significantly impact your treatment journey and overall prognosis.
Call us now at +1(267) 388-9828 to schedule your test or speak with our oncology specialists. Our team is ready to answer your questions, explain the testing process, and help you take the next step toward comprehensive cancer care.
Early and accurate diagnosis through advanced testing like the Immunohistochemistry ATRX Test can make a substantial difference in treatment outcomes. Trust our expertise in molecular diagnostics to provide the clarity and guidance you need for your healthcare journey.
