Immunohistochemistry Cytokeratin 20 (CK20) Test
Understanding the CK20 Test
The Immunohistochemistry Cytokeratin 20 (CK20) Test represents a cornerstone in modern cancer diagnostics, utilizing advanced immunohistochemical techniques to detect specific protein markers in tissue samples. This sophisticated laboratory procedure helps healthcare providers accurately classify various types of carcinomas, enabling more precise treatment decisions and improved patient outcomes.
What is Cytokeratin 20?
Cytokeratin 20 is a specific type of intermediate filament protein expressed in certain epithelial cells. Unlike other cytokeratins that are widely distributed, CK20 has a restricted expression pattern, making it an invaluable diagnostic marker for identifying specific cancer types and distinguishing between different tumor origins.
What the Test Measures and Detects
The Immunohistochemistry CK20 Test specifically identifies the presence and distribution of cytokeratin 20 protein within tissue samples. This advanced diagnostic tool provides critical information about:
- Presence of CK20 protein expression in tumor cells
- Pattern and intensity of CK20 staining
- Cellular localization of the marker
- Percentage of positive tumor cells
- Comparison with other cytokeratin markers for differential diagnosis
Who Should Consider This Test
The CK20 test is particularly valuable for patients with:
- Suspected gastrointestinal carcinomas (colorectal, gastric, pancreatic)
- Urothelial (bladder) carcinoma evaluation
- Merkel cell carcinoma diagnosis
- Metastatic tumors of unknown primary origin
- Differentiation between various adenocarcinoma types
- Patients with abnormal biopsy findings requiring further characterization
Clinical Indications
This test is commonly ordered when patients present with symptoms including unexplained weight loss, gastrointestinal bleeding, abdominal pain, urinary symptoms, or when imaging studies reveal suspicious masses requiring pathological confirmation and classification.
Benefits of Taking the CK20 Test
- Accurate Cancer Classification: Helps distinguish between different types of carcinomas with similar histological appearances
- Treatment Guidance: Provides essential information for selecting appropriate targeted therapies
- Prognostic Information: Certain CK20 expression patterns correlate with disease progression and outcomes
- Metastasis Identification: Aids in determining the origin of metastatic tumors
- Personalized Medicine: Enables tailored treatment approaches based on specific biomarker profiles
Understanding Your Test Results
Your CK20 test results will be interpreted by experienced pathologists and may include:
Positive CK20 Expression
A positive result typically indicates the presence of CK20 protein in the tested tissue. This finding is commonly associated with:
- Gastrointestinal adenocarcinomas (colorectal, gastric)
- Urothelial carcinomas
- Merkel cell carcinomas
- Some mucinous ovarian tumors
- Cholangiocarcinomas
Negative CK20 Expression
A negative result suggests the absence of CK20 protein and may indicate:
- Lung adenocarcinomas
- Breast carcinomas
- Prostate adenocarcinomas
- Mesotheliomas
- Certain neuroendocrine tumors
Interpretation Context
It’s important to understand that CK20 results are typically interpreted in conjunction with other immunohistochemical markers (such as CK7) and clinical information. Your healthcare provider will discuss the specific implications of your results in the context of your overall clinical picture.
Test Pricing Information
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $88 |
| Regular Price | $126 |
Turnaround Time and Sample Requirements
Our laboratory maintains efficient processing times to ensure timely results:
- Sample Acceptance: Daily by 6 PM
- Standard Tissue Block: 5 days
- Tissue Biopsy: 5 days
- Large Complex Tissue: 7 days
Sample Submission Guidelines
For accurate testing, please submit:
- Tumor tissue preserved in 10% formal-saline OR
- Formalin-fixed paraffin-embedded tissue block
- Ship samples at room temperature
- Include complete clinical documentation
Required Documentation
To ensure proper test interpretation, please provide:
- Copy of the histopathology report
- Specific site of biopsy
- Detailed clinical history
- Relevant imaging studies if available
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network of certified laboratories ensures consistent, high-quality testing standards nationwide.
Book Your Test Today
Take the next step in your diagnostic journey with confidence. Our team of experienced oncologists and pathologists is ready to provide you with comprehensive testing and expert interpretation. Contact us today to schedule your Immunohistochemistry Cytokeratin 20 Test.
Call or WhatsApp: +1(267) 388-9828
Don’t delay critical diagnostic information. Early and accurate cancer classification can significantly impact treatment success and patient outcomes. Our dedicated healthcare professionals are available to answer your questions and guide you through the testing process.
