Immunohistochemistry CD21 Test
Understanding the Immunohistochemistry CD21 Test
The Immunohistochemistry CD21 Test represents a cutting-edge diagnostic approach in modern pathology and oncology. This specialized laboratory technique utilizes advanced antibody-based staining methods to detect the presence and distribution of CD21 protein within tissue samples. CD21, also known as complement receptor 2 (CR2), serves as a critical biomarker primarily expressed on mature B-lymphocytes and follicular dendritic cells within the immune system.
This sophisticated diagnostic tool plays an indispensable role in cancer diagnosis and characterization, particularly in hematological malignancies. By providing precise visualization of cellular architecture and protein expression patterns, the CD21 test enables healthcare professionals to make accurate diagnostic determinations and develop targeted treatment strategies.
What the CD21 Test Measures and Detects
The Immunohistochemistry CD21 Test specifically identifies and quantifies the expression of CD21 antigen within tissue specimens. This comprehensive analysis provides crucial information about:
- Presence and distribution of CD21-positive B-cells
- Architecture of follicular dendritic cell networks
- Patterns of lymphoid tissue organization
- Identification of abnormal cellular proliferation
- Characterization of lymphoma subtypes
This test is particularly valuable for distinguishing between different types of lymphomas and assessing the integrity of the immune system’s architecture. The detection of CD21 expression patterns helps pathologists differentiate between reactive lymphoid hyperplasia and malignant lymphoproliferative disorders.
Who Should Consider the CD21 Test?
This specialized diagnostic test is recommended for individuals presenting with specific clinical indications and symptoms, including:
Primary Clinical Indications
- Patients with unexplained lymph node enlargement or swelling
- Individuals with suspected lymphoma based on clinical presentation
- Cases requiring differentiation between benign and malignant lymphoid proliferations
- Patients with abnormal blood counts suggesting hematological disorders
- Individuals with persistent fever, night sweats, or unexplained weight loss
Symptom Profile
- Persistent lymphadenopathy (swollen lymph nodes)
- Unexplained fatigue and weakness
- Recurrent infections or immune system abnormalities
- Night sweats and unexplained fever
- Unexplained weight loss exceeding 10% of body weight
Benefits of Taking the CD21 Test
The Immunohistochemistry CD21 Test offers numerous advantages for patients and healthcare providers:
Diagnostic Precision
This test provides highly specific information about cellular composition and organization, enabling accurate diagnosis and classification of lymphoid disorders. The precise identification of CD21 expression patterns helps distinguish between various lymphoma subtypes, guiding appropriate treatment selection.
Treatment Guidance
By characterizing the specific type of lymphoid proliferation, the CD21 test assists oncologists in developing targeted treatment strategies. The information obtained helps determine whether aggressive chemotherapy, radiation therapy, or watchful waiting represents the most appropriate approach.
Prognostic Information
The pattern and intensity of CD21 staining provide valuable prognostic information, helping predict disease behavior and potential treatment response. This enables healthcare providers to establish realistic expectations and optimize patient management strategies.
Monitoring Capabilities
For patients undergoing treatment, subsequent CD21 testing can monitor treatment response and detect early signs of disease recurrence, allowing for timely intervention and treatment adjustments.
Understanding Your Test Results
Interpreting CD21 test results requires specialized expertise from trained pathologists and oncologists. Here’s a general guide to understanding your results:
Normal Findings
Normal CD21 staining typically shows well-organized follicular dendritic cell networks within lymphoid tissues. The presence of CD21-positive B-cells in expected anatomical locations indicates normal immune system architecture.
Abnormal Patterns
- Increased CD21 Expression: May indicate certain types of B-cell lymphomas or reactive conditions
- Decreased or Absent CD21: Could suggest specific lymphoma subtypes or immune deficiencies
- Disrupted Architecture: Often indicates malignant transformation or significant immune system disruption
- Atypical Distribution: May suggest specific lymphoma subtypes requiring specialized treatment approaches
Clinical Correlation
Your healthcare provider will correlate CD21 test results with clinical findings, other laboratory tests, and imaging studies to establish a comprehensive diagnosis and treatment plan. The CD21 findings represent one piece of the diagnostic puzzle that, when combined with other information, provides a complete clinical picture.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Immunohistochemistry CD21 Test | $76 USD | $112 USD |
Nationwide Testing Availability
GGC DNA maintains comprehensive testing facilities across the United States, ensuring convenient access to the Immunohistochemistry CD21 Test in all major metropolitan areas. Our network includes specialized laboratories in:
- New York City and surrounding regions
- Los Angeles and Southern California
- Chicago and the Midwest
- Houston and Texas metropolitan areas
- Miami and Florida locations
- Seattle and Pacific Northwest facilities
- Boston and New England regions
- Atlanta and Southeastern centers
Sample Requirements and Processing
For accurate CD21 testing, proper sample collection and handling are essential:
Sample Type
- Submit tumor tissue preserved in 10% formal-saline solution
- Formalin-fixed paraffin-embedded tissue blocks
- Ship samples at room temperature with appropriate packaging
Required Documentation
- Complete Histopathology report
- Detailed site of biopsy information
- Comprehensive clinical history
Turnaround Times
- Sample acceptance: Daily by 6:00 PM
- Tissue block processing: 5 days
- Standard tissue biopsy: 5 days
- Large complex tissue specimens: 7 days
Take Action for Your Health
Don’t delay in obtaining the critical diagnostic information provided by the Immunohistochemistry CD21 Test. Early and accurate diagnosis significantly improves treatment outcomes and quality of life. Our team of experienced pathologists and laboratory specialists stands ready to provide you with precise, reliable results.
Book your Immunohistochemistry CD21 Test today by calling our dedicated healthcare line at +1(267) 388-9828 or schedule your appointment through our online booking system. Take the first step toward comprehensive diagnostic clarity and personalized treatment planning with GGC DNA’s advanced testing capabilities.
