Immunohistochemistry CD15 Test
Comprehensive Introduction to CD15 Immunohistochemistry Testing
The Immunohistochemistry CD15 Test represents a cornerstone in modern cancer diagnostics, utilizing advanced molecular techniques to detect specific cellular markers that play crucial roles in tumor identification and classification. This sophisticated laboratory procedure combines the precision of immunohistochemistry with the specificity of CD15 antigen detection, providing clinicians with invaluable information for accurate cancer diagnosis and treatment planning.
Immunohistochemistry (IHC) has revolutionized cancer pathology by enabling the visualization of specific proteins within tissue samples. The CD15 test specifically targets the CD15 antigen, also known as Lewis X or stage-specific embryonic antigen-1 (SSEA-1), which serves as a critical biomarker in various hematologic malignancies and solid tumors. This test’s importance extends beyond mere detection—it provides essential data for tumor typing, prognosis assessment, and therapeutic decision-making.
What the CD15 Test Measures and Detects
The Immunohistochemistry CD15 Test specifically identifies the presence and distribution of the CD15 antigen within tissue samples. This carbohydrate antigen is primarily expressed on:
- Granulocytes (neutrophils, eosinophils)
- Reed-Sternberg cells in Hodgkin lymphoma
- Certain myeloid leukemia cells
- Select epithelial tumors
- Germ cell tumors
The test utilizes specialized antibodies that bind specifically to the CD15 antigen, followed by visualization techniques that highlight positive cells under microscopic examination. This allows pathologists to determine not only the presence of CD15 but also its pattern of expression, intensity, and cellular localization—all critical factors in diagnostic interpretation.
Clinical Applications and Detection Capabilities
The CD15 test is particularly valuable for:
- Diagnosing and classifying Hodgkin lymphoma
- Distinguishing between different types of lymphomas
- Identifying myeloid lineage in acute leukemias
- Detecting certain carcinomas and germ cell tumors
- Providing prognostic information in specific cancer types
Who Should Consider the CD15 Immunohistochemistry Test
This specialized test is recommended for patients presenting with:
Suspected Hematologic Malignancies
- Unexplained lymphadenopathy (swollen lymph nodes)
- Persistent fever, night sweats, or unexplained weight loss
- Abnormal blood counts suggesting bone marrow involvement
- Suspected lymphoma based on imaging studies
Cancer Diagnosis and Staging
- Patients with biopsy-proven tumors requiring precise classification
- Individuals with metastatic cancer of unknown primary origin
- Cases where routine histopathology provides inconclusive results
- Patients requiring targeted therapy selection
Treatment Monitoring and Follow-up
- Post-treatment evaluation for residual disease
- Assessment of treatment response in known CD15-positive malignancies
- Recurrence monitoring in previously diagnosed cases
Significant Benefits of CD15 Testing
Precision in Diagnosis
The CD15 test provides unparalleled specificity in identifying particular cancer subtypes, enabling accurate diagnosis that directly impacts treatment decisions. This precision reduces diagnostic uncertainty and ensures patients receive the most appropriate therapeutic interventions.
Enhanced Treatment Planning
By accurately identifying CD15-positive malignancies, clinicians can tailor treatment strategies to target specific molecular characteristics, potentially improving treatment efficacy while minimizing unnecessary side effects from inappropriate therapies.
Prognostic Value
CD15 expression patterns can provide valuable prognostic information, helping physicians predict disease behavior and outcomes, which informs both treatment intensity and follow-up strategies.
Comprehensive Cancer Profiling
When used as part of a broader immunohistochemistry panel, the CD15 test contributes to comprehensive tumor profiling, offering a more complete understanding of the cancer’s biological characteristics.
Understanding Your CD15 Test Results
Interpretation Guidelines
CD15 test results are interpreted by board-certified pathologists who consider multiple factors:
- Positive Result: Indicates CD15 antigen expression, typically seen in Hodgkin lymphoma, certain leukemias, and specific carcinomas. The pattern and intensity of staining provide additional diagnostic information.
- Negative Result: Absence of CD15 expression, which may help exclude certain diagnoses or suggest alternative tumor types.
- Focal/Patchy Staining: Limited CD15 expression that may have specific diagnostic implications depending on the clinical context.
Clinical Correlation
It’s essential to understand that CD15 results are interpreted in conjunction with:
- Clinical history and presentation
- Other laboratory findings
- Additional immunohistochemistry markers
- Morphological features from routine histology
Next Steps After Testing
Your healthcare provider will discuss the results in the context of your overall clinical picture and develop an appropriate management plan. Positive results typically lead to targeted treatment strategies, while negative results may prompt further diagnostic evaluation.
Test Pricing and Availability
| Test Description | Price (USD) |
|---|---|
| Immunohistochemistry CD15 Test – Discount Price | $76 |
| Immunohistochemistry CD15 Test – Regular Price | $112 |
Turnaround Time
- Sample Acceptance: Daily by 6 PM
- Report Delivery: Block – 5 days | Tissue Biopsy – 5 days | Tissue Large Complex – 7 days
Sample Requirements
Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block. Ship at room temperature. Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Nationwide Availability and Booking
GGC DNA maintains comprehensive diagnostic facilities across the United States, with branches in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures convenient access to advanced cancer diagnostics regardless of your location.
Why Choose GGC DNA for Your CD15 Testing?
- Board-certified pathologists specializing in oncologic diagnostics
- State-of-the-art immunohistochemistry laboratories
- Rapid turnaround times without compromising accuracy
- Comprehensive result interpretation and clinical correlation
- Seamless integration with your healthcare team
Take Action Today
Don’t leave your cancer diagnosis to chance. The Immunohistochemistry CD15 Test provides critical information that can significantly impact your treatment journey and outcomes. Our team of oncology specialists and pathologists are ready to provide you with the accurate, timely diagnostic information you need.
Book your Immunohistochemistry CD15 Test today by calling +1(267) 388-9828 or schedule through our online portal. Take the first step toward precise cancer diagnosis and personalized treatment planning.
Our dedicated patient care coordinators are available to answer your questions, assist with insurance inquiries, and help coordinate testing with your healthcare provider. Trust GGC DNA for comprehensive, reliable cancer diagnostics that put your health first.
