Immunohistochemistry H3K27M H3K27me3 Test
Comprehensive Introduction to H3K27M H3K27me3 Testing
The Immunohistochemistry H3K27M H3K27me3 Test represents a groundbreaking advancement in cancer diagnostics, specifically designed to detect critical histone mutations that drive tumor development and progression. This sophisticated laboratory analysis provides oncologists with essential molecular information that directly impacts treatment decisions and patient outcomes.
Histone proteins play a fundamental role in DNA packaging and gene regulation within our cells. When mutations occur in these proteins, particularly the H3K27M alteration, they can trigger aggressive cancer development. The H3K27M H3K27me3 Test simultaneously evaluates both the presence of the H3K27M mutation and the loss of H3K27me3 modification, offering a comprehensive view of the tumor’s molecular landscape.
What This Advanced Test Measures and Detects
The Immunohistochemistry H3K27M H3K27me3 Test specifically identifies:
- H3K27M Mutation Detection: Identifies the presence of specific histone H3 mutations that are characteristic of certain aggressive brain tumors
- H3K27me3 Expression Analysis: Evaluates the trimethylation status of histone H3 at lysine 27, which is often lost in mutation-positive tumors
- Tumor Classification: Helps classify diffuse midline gliomas and other central nervous system tumors based on molecular markers
- Treatment Response Prediction: Provides insights into potential treatment responses and resistance patterns
Who Should Consider This Critical Diagnostic Test
This specialized test is particularly important for patients experiencing:
- Suspected or confirmed brain tumors, especially those located in midline structures
- Diagnosis of diffuse intrinsic pontine glioma (DIPG) in pediatric patients
- Aggressive gliomas with unusual presentation or rapid progression
- Cases where standard histopathology requires molecular confirmation
- Patients being evaluated for targeted therapy options
- Individuals with family history of genetic cancer syndromes
Clinical Symptoms That May Indicate Need for Testing
- Persistent headaches with neurological symptoms
- Vision changes or coordination difficulties
- Unexplained seizures or cognitive changes
- Progressive weakness or sensory alterations
- Speech difficulties or personality changes
Significant Benefits of H3K27M H3K27me3 Testing
Undergoing this advanced diagnostic procedure offers multiple advantages:
- Precise Diagnosis: Provides definitive molecular classification of tumors beyond traditional histology
- Treatment Guidance: Informs targeted therapy selection and clinical trial eligibility
- Prognostic Information: Offers valuable insights into disease progression and expected outcomes
- Personalized Medicine: Enables tailored treatment approaches based on specific molecular alterations
- Early Intervention: Facilitates timely treatment decisions that can significantly impact patient survival
- Comprehensive Care: Supports multidisciplinary treatment planning involving neuro-oncologists, radiation oncologists, and neurosurgeons
Understanding Your Test Results
Your H3K27M H3K27me3 test results will be carefully interpreted by our expert pathologists and oncologists:
Possible Result Interpretations
- H3K27M Positive / H3K27me3 Lost: Typically indicates diffuse midline glioma with H3K27M mutation, requiring specialized treatment approaches
- H3K27M Negative / H3K27me3 Retained: Suggests alternative tumor types that may respond to different treatment strategies
- Mixed Patterns: May indicate tumor heterogeneity or evolving molecular characteristics
- Borderline Results: May require additional testing or clinical correlation
All results are accompanied by detailed explanations and recommendations from our medical team. Your oncologist will discuss the implications of your specific results and develop a personalized treatment plan based on the molecular findings.
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Immunohistochemistry H3K27M H3K27me3 Test | $88 USD | $112 USD |
Turnaround Time and Sample Requirements
- Sample Submission: Daily by 6 PM
- Report Timeline: Block samples: 5 days | Tissue Biopsy: 5 days | Complex Tissue: 7 days
- Sample Type: Submit tumor tissue in 10% formal-saline OR formalin fixed paraffin embedded block
- Shipping: Ship at room temperature with proper documentation
- Required Documentation: Histopathology report, biopsy site information, and complete clinical history
Nationwide Availability and Convenient Testing
General Genetics Corporation provides comprehensive H3K27M H3K27me3 testing services across the United States. Our state-of-the-art laboratories and experienced histology specialists ensure accurate and reliable results for patients in:
- New York, Los Angeles, Chicago, Houston, Phoenix
- Philadelphia, San Antonio, San Diego, Dallas, San Jose
- All major metropolitan areas and regional centers
- Rural communities through our network of collection partners
Take Action for Your Health Today
Don’t delay critical cancer diagnosis and treatment planning. The Immunohistochemistry H3K27M H3K27me3 Test provides essential molecular information that can significantly impact your treatment journey and outcomes.
Call us now at +1(267) 388-9828 to schedule your test or speak with our oncology specialists. Our team is available to answer your questions, explain the testing process, and help you understand how this advanced diagnostic can benefit your specific situation.
With convenient locations nationwide and expert medical guidance, General Genetics Corporation makes advanced cancer diagnostics accessible and understandable for every patient. Trust our commitment to excellence in molecular pathology and personalized cancer care.
