Immunoglobulin IgG Subclass 4 Test
Comprehensive Immune System Analysis
The Immunoglobulin IgG Subclass 4 Test represents a sophisticated diagnostic tool designed to evaluate specific components of your immune system’s defense mechanisms. Immunoglobulin G (IgG) is the most abundant antibody class in human serum, comprising approximately 75-80% of all circulating antibodies. Within the IgG class, there are four distinct subclasses (IgG1, IgG2, IgG3, and IgG4), each with unique biological functions and structural characteristics.
IgG4 antibodies play specialized roles in immune regulation and protection against specific pathogens. Unlike other IgG subclasses, IgG4 has unique properties including functional monovalency and the ability to undergo Fab-arm exchange, which contributes to its anti-inflammatory characteristics. This test provides crucial insights into your immune system’s capacity to mount appropriate responses to infections, allergens, and other immunological challenges.
What Does the Immunoglobulin IgG Subclass 4 Test Measure?
This specialized laboratory assessment precisely quantifies the concentration of IgG4 antibodies circulating in your bloodstream. The test specifically measures:
- Absolute IgG4 antibody levels in milligrams per deciliter (mg/dL)
- Relative proportion of IgG4 within the total IgG spectrum
- Comparison against established reference ranges for different age groups
- Detection of abnormal IgG4 patterns that may indicate underlying conditions
Using advanced nephelometry technology, the test provides highly accurate and reproducible results. Nephelometry measures the concentration of particles in a solution by detecting the amount of light scattered by the antigen-antibody complexes formed during the testing process, ensuring precise quantification of IgG4 levels.
Who Should Consider This Test?
Clinical Indications and Symptoms
The Immunoglobulin IgG Subclass 4 Test is recommended for individuals experiencing:
- Recurrent Infections: Frequent respiratory, sinus, or ear infections that suggest possible immune deficiency
- Autoimmune Symptoms: Unexplained inflammatory conditions or suspected autoimmune disorders
- IgG4-Related Disease Suspicions: Symptoms including swelling of glands, pancreatic inflammation, or retroperitoneal fibrosis
- Poor Response to Vaccinations: Inadequate immune response to standard immunizations
- Chronic Fatigue and Malaise: Persistent tiredness without clear explanation
- Family History: Known inherited immunodeficiency disorders in close relatives
- Monitoring Treatment: Patients undergoing immunoglobulin replacement therapy or immunosuppressive treatments
Benefits of Taking the Immunoglobulin IgG Subclass 4 Test
Undergoing this comprehensive immune assessment provides numerous clinical advantages:
- Early Detection: Identify immune system abnormalities before they lead to serious complications
- Accurate Diagnosis: Differentiate between various types of immunodeficiency disorders
- Personalized Treatment Planning: Guide appropriate therapeutic interventions based on specific immune deficiencies
- Disease Monitoring: Track the effectiveness of treatments for immune-related conditions
- Preventive Health Insights: Understand your immune system’s strengths and vulnerabilities
- Comprehensive Immune Profile: Gain valuable information about your body’s defense mechanisms
Understanding Your Test Results
Interpretation Guidelines
Your Immunoglobulin IgG Subclass 4 Test results will be interpreted by qualified healthcare professionals, but here’s general guidance on understanding the findings:
Normal IgG4 Levels
Normal IgG4 concentrations typically range between 8-140 mg/dL in adults, though reference ranges may vary slightly between laboratories. Normal results indicate adequate IgG4 production and suggest proper immune system function for this specific antibody subclass.
Elevated IgG4 Levels
Increased IgG4 concentrations may indicate:
- IgG4-related diseases affecting various organs
- Chronic inflammatory conditions
- Allergic disorders or atopic conditions
- Certain autoimmune diseases
- Parasitic infections in some cases
Decreased IgG4 Levels
Low IgG4 levels might suggest:
- Selective IgG4 deficiency
- Common variable immunodeficiency (CVID)
- Other primary immunodeficiency disorders
- Secondary immunodeficiencies due to underlying conditions
It’s essential to discuss your specific results with your healthcare provider, who will consider your complete clinical picture, symptoms, and other laboratory findings to provide comprehensive interpretation and recommendations.
Test Details and Pricing
| Test Component | Details |
|---|---|
| Test Name | Immunoglobulin IgG Subclass 4 Test |
| Discount Price | $226 USD |
| Regular Price | $376 USD |
| Sample Type | 2 mL (1 mL min.) serum from 1 SST |
| Sample Requirements | Ship refrigerated or frozen |
| Turnaround Time | Same day (Sample Mon/Thu by 4 pm) |
| Testing Method | Nephelometry |
| Pre-test Instructions | Overnight fasting is preferred |
Nationwide Accessibility
GGC DNA maintains comprehensive testing facilities across the United States, ensuring convenient access to the Immunoglobulin IgG Subclass 4 Test in all major metropolitan areas. Our state-of-the-art laboratories in New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose provide consistent, high-quality testing services with rapid turnaround times.
Each facility adheres to strict quality control standards and employs certified laboratory professionals to ensure the accuracy and reliability of your test results. Our nationwide network allows for seamless sample processing and result delivery, regardless of your location within the United States.
Take Control of Your Immune Health Today
Understanding your immune system’s function is crucial for maintaining optimal health and preventing serious complications. The Immunoglobulin IgG Subclass 4 Test provides valuable insights that can guide appropriate medical interventions and help you make informed decisions about your healthcare.
Don’t wait to address concerns about your immune function. Our team of experienced healthcare professionals is ready to assist you in scheduling your test and answering any questions you may have about the procedure, preparation, or results interpretation.
Book your Immunoglobulin IgG Subclass 4 Test today by calling +1(267) 388-9828 or visiting your nearest GGC DNA location. Take the first step toward comprehensive immune system evaluation and personalized health management.
