HLA T & B Cell Lymphocyte Crossmatch Test
Understanding HLA Crossmatch Testing for Organ Transplantation
The HLA T & B Cell Lymphocyte Crossmatch Test represents a cornerstone of modern transplant medicine, providing critical immunological assessment before organ transplantation procedures. This sophisticated laboratory analysis evaluates the compatibility between donor and recipient immune systems, specifically targeting potential antibody-mediated rejection risks that could compromise transplant success.
What Does the HLA Crossmatch Test Measure?
This comprehensive test detects and measures donor-specific antibodies in the recipient’s serum that could target donor T and B lymphocytes. The test utilizes advanced Complement Dependent Cytotoxicity methodology with DTT treatment to:
- Identify pre-formed antibodies against donor HLA antigens
- Assess both T cell and B cell reactivity patterns
- Detect current and historical sensitization events
- Evaluate crossmatch compatibility for transplant safety
Who Should Consider HLA Crossmatch Testing?
This essential test is recommended for:
- Organ transplant candidates awaiting kidney, heart, liver, or pancreas transplantation
- Patients with previous transplant history requiring re-evaluation
- Individuals with blood transfusion history that may cause sensitization
- Women with pregnancy history who may have developed HLA antibodies
- Patients with autoimmune conditions that could affect transplant compatibility
Clinical Indications and Symptoms
While this is primarily a preventive screening test, it’s crucial for patients experiencing:
- End-stage renal disease requiring transplantation
- Heart failure patients awaiting cardiac transplantation
- Liver failure candidates for transplant evaluation
- Previous transplant rejection episodes
- Known HLA sensitization from prior medical events
Benefits of HLA Crossmatch Testing
Undergoing HLA crossmatch testing provides numerous advantages for transplant success:
- Prevents Hyperacute Rejection: Identifies incompatible donor-recipient pairs before transplantation
- Improves Transplant Outcomes: Reduces risk of early graft failure
- Personalized Treatment Planning: Guides immunosuppression strategies
- Enhanced Safety: Minimizes post-transplant complications
- Informed Decision Making: Provides critical data for transplant team decisions
Understanding Your Test Results
Your HLA crossmatch results will be interpreted by experienced transplant immunologists:
- Negative Crossmatch: Indicates no detectable donor-specific antibodies, suggesting compatibility
- Positive Crossmatch: Shows presence of donor-reactive antibodies, requiring careful evaluation
- T Cell vs B Cell Reactivity: Different patterns provide specific risk assessment information
- Clinical Correlation: Results are interpreted in context with your complete medical history
Test Pricing Information
| Test Description | Price (USD) |
|---|---|
| HLA T & B Cell Lymphocyte Crossmatch Test – Discount Price | $250 |
| HLA T & B Cell Lymphocyte Crossmatch Test – Regular Price | $326 |
Nationwide Testing Availability
We provide comprehensive HLA crossmatch testing services across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more cities. Our network of certified laboratories ensures consistent, high-quality testing standards nationwide.
Sample Collection Requirements
Proper specimen collection is essential for accurate results:
- Recipient Specimen: 6 mL whole blood in Yellow Top (ACD) tube AND 3 mL serum from SST
- Donor Specimen: 12 mL whole blood in 2 Yellow Top (ACD) tubes
- Timing: Collect recipient specimen preferably 48 hours after dialysis
- Shipping: Refrigerated transport required – DO NOT FREEZE
- Documentation: Doctor’s prescription, photographs, and Solid Organ Transplant Consent form mandatory
Take the Next Step Toward Transplant Success
Don’t leave your transplant compatibility to chance. Our HLA T & B Cell Lymphocyte Crossmatch Test provides the critical immunological information needed for safe and successful organ transplantation. With results delivered within 10-12 days and our comprehensive nationwide network, we make transplant compatibility testing accessible and reliable.
Ready to schedule your HLA crossmatch test? Call our transplant specialists today at +1(267) 388-9828 or book your appointment online. Your journey to successful transplantation begins with accurate compatibility assessment.
