HLA DNA Typing for Bone Marrow Transplant 10 Antigens PCR Test
Comprehensive Introduction to HLA DNA Typing
HLA DNA Typing for Bone Marrow Transplant represents a cornerstone of modern transplant medicine, providing critical genetic matching information that can determine the success or failure of life-saving bone marrow transplantation procedures. This sophisticated PCR-based test analyzes 10 specific human leukocyte antigens (HLA) that play a fundamental role in immune system recognition and compatibility between donors and recipients.
The importance of HLA matching cannot be overstated in transplantation medicine. When HLA types between donor and recipient closely match, the recipient’s immune system is less likely to recognize the transplanted bone marrow as foreign and attack it. Conversely, significant mismatches can lead to devastating complications including graft rejection, graft-versus-host disease (GVHD), and poor engraftment outcomes.
What This Test Measures and Detects
Our advanced HLA DNA Typing test specifically examines 10 critical antigens across five major HLA loci using Sequence Specific Primer (SSP) PCR methodology:
- HLA-A Locus: Identifies specific A series antigens crucial for immune recognition
- HLA-B Locus: Analyzes B series antigens that influence transplant compatibility
- HLA-C Locus: Examines C series antigens important for natural killer cell regulation
- HLA-DR Locus: Tests DR antigens critical for immune response coordination
- HLA-DQ Locus: Assesses DQ antigens that impact long-term transplant success
The PCR-SSP methodology provides high-resolution typing with exceptional accuracy, enabling precise matching that significantly improves transplant outcomes and reduces complication risks.
Who Should Consider HLA DNA Typing
This essential test is recommended for several patient populations and clinical scenarios:
Primary Candidates Include:
- Patients diagnosed with leukemia, lymphoma, or multiple myeloma requiring bone marrow transplantation
- Individuals with aplastic anemia or other bone marrow failure syndromes
- Patients with inherited immune deficiencies or metabolic disorders
- Potential bone marrow donors being evaluated for family members or registry matching
- Patients with sickle cell disease or thalassemia considering curative transplantation
Clinical Indications:
- Preparation for allogeneic bone marrow or stem cell transplantation
- Family donor compatibility assessment
- Unrelated donor search through national registries
- Cord blood unit matching evaluation
- Pre-transplant compatibility confirmation
Significant Benefits of HLA DNA Testing
Undergoing HLA DNA Typing provides numerous critical advantages for transplant candidates and their medical teams:
- Enhanced Transplant Success: Precise HLA matching significantly improves engraftment rates and reduces rejection risks
- Reduced GVHD Risk: Better HLA compatibility minimizes the likelihood and severity of graft-versus-host disease
- Informed Donor Selection: Enables identification of the most suitable donor from available options
- Improved Survival Outcomes: Well-matched transplants demonstrate superior long-term survival statistics
- Comprehensive Compatibility Assessment: Evaluates multiple HLA loci for thorough matching analysis
- Advanced Technology: PCR-SSP methodology ensures high accuracy and reliability
Understanding Your Test Results
Interpreting HLA typing results requires specialized hematological expertise, but general guidance includes:
Result Interpretation Framework:
- Full Match: Identical HLA types across all tested loci represent ideal donor-recipient compatibility
- Partial Match: Some antigen differences may be acceptable depending on clinical circumstances
- Mismatch: Significant differences typically require alternative donor consideration
- Haplotype Analysis: Family testing may identify haploidentical donors when full matches aren’t available
Your hematologist will explain your specific results in detail, discussing compatibility levels, potential donor options, and implications for your transplant journey. The degree of matching required may vary based on your specific medical condition, age, and available donor sources.
Test Pricing and Specifications
| Test Feature | Details |
|---|---|
| Test Name | HLA DNA Typing for Bone Marrow Transplant 10 Antigens PCR Test |
| Discount Price | $614 USD |
| Regular Price | $682 USD |
| Turnaround Time | 10-12 days |
| Sample Type | 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube |
| Shipping Instructions | Ship refrigerated. DO NOT FREEZE |
| Testing Methodology | SSP – PCR (Sequence Specific Primer Polymerase Chain Reaction) |
| Test Components | HLA-A, B, C, DR & DQ Low Resolution Typing |
| Preparation Required | No special preparation required |
Nationwide Testing Accessibility
We maintain comprehensive testing facilities across the United States, ensuring convenient access to this critical HLA typing service. Our network includes specialized collection centers in major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Each facility maintains the highest standards of sample processing and genetic testing expertise.
Take the Next Step Toward Transplantation Success
Don’t leave your transplant compatibility to chance. Our HLA DNA Typing test provides the essential genetic information needed to optimize your bone marrow transplantation journey. With rapid 10-12 day turnaround and comprehensive 10-antigen analysis, you’ll receive the detailed matching information required for informed medical decisions.
Ready to begin your transplant compatibility assessment? Contact our specialized transplantation genetics team today to schedule your HLA DNA typing test. Call or WhatsApp us at +1(267) 388-9828 to book your appointment or discuss your testing needs with our genetic counseling specialists.
Early HLA typing can significantly streamline your transplant preparation process and help identify potential donors more efficiently. Take control of your transplantation journey with precise, reliable genetic matching information from America’s leading genetics testing provider.
