HLA Celiac Disease DRDQB1DQA1 Haplotype Association Including DQ2DQ8 Test
Comprehensive Genetic Screening for Celiac Disease Risk
The HLA Celiac Disease DRDQB1DQA1 Haplotype Association Including DQ2DQ8 Test represents a cutting-edge genetic screening approach for identifying individuals at risk for developing celiac disease. This sophisticated molecular analysis examines specific human leukocyte antigen (HLA) genes that play a crucial role in the immune system’s response to gluten proteins. Understanding your genetic predisposition to celiac disease can provide invaluable insights for early intervention and personalized dietary management strategies.
What Does This Test Measure?
This advanced genetic test specifically targets the HLA-DQB1 and HLA-DQA1 gene regions, focusing on the detection of DQ2 and DQ8 haplotypes. These genetic markers are strongly associated with celiac disease susceptibility:
- DQ2 Haplotype Detection: Identifies the presence of HLA-DQ2.5 and HLA-DQ2.2 variants
- DQ8 Haplotype Analysis: Screens for HLA-DQ8 genetic markers
- Comprehensive HLA Profiling: Examines the complete DRDQB1DQA1 haplotype association
- Genetic Risk Assessment: Determines your inherited predisposition to celiac disease
Who Should Consider This Genetic Test?
This test is particularly recommended for individuals experiencing:
- Unexplained gastrointestinal symptoms including chronic diarrhea, bloating, or abdominal pain
- Family history of celiac disease or autoimmune disorders
- Iron-deficiency anemia or other nutritional deficiencies
- Unexplained weight loss or failure to thrive in children
- Associated autoimmune conditions like type 1 diabetes or thyroid disease
- Dermatitis herpetiformis or other skin manifestations
- Unexplained elevated liver enzymes
- First-degree relatives of confirmed celiac disease patients
Clinical Benefits of HLA Celiac Testing
Undergoing HLA celiac disease genetic testing offers numerous advantages:
- Early Risk Identification: Detect genetic predisposition before symptoms develop
- Diagnostic Clarity: Help confirm or exclude celiac disease in complex cases
- Family Screening: Identify at-risk relatives for proactive monitoring
- Personalized Management: Guide dietary and lifestyle interventions
- Reduced Diagnostic Uncertainty: Provide definitive genetic evidence
- Cost-Effective Screening: Avoid unnecessary invasive procedures
Understanding Your Test Results
Your HLA celiac disease genetic test results will fall into one of several categories:
- Positive for DQ2/DQ8: Indicates genetic susceptibility to celiac disease. This result doesn’t confirm active disease but suggests increased risk. Further antibody testing and clinical evaluation are recommended.
- Negative for DQ2/DQ8: Strongly suggests celiac disease is unlikely (over 99% negative predictive value). Alternative causes for symptoms should be investigated.
- Partial Haplotype Detection: Some individuals may carry only partial DQ2 components, which still confer some risk but typically lower than complete haplotypes.
Test Pricing and Availability
| Test Component | Price (USD) |
|---|---|
| HLA Celiac Disease DRDQB1DQA1 Haplotype Association Including DQ2DQ8 Test – Discount Price | $200 |
| HLA Celiac Disease DRDQB1DQA1 Haplotype Association Including DQ2DQ8 Test – Regular Price | $376 |
Nationwide Testing Availability
We proudly offer comprehensive genetic testing services across the United States with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our state-of-the-art laboratories ensure consistent, reliable results regardless of your location.
Sample Collection and Processing
This test requires a simple blood draw with the following specifications:
- Sample Type: 4 mL (3 mL minimum) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL minimum) whole blood in 1 Yellow Top (ACD) tube
- Shipping Instructions: Ship refrigerated. DO NOT FREEZE
- Turnaround Time: 1 week
- Preparation: No special preparation required
- Testing Methodology: Sequence Specific Primer – Polymerase Chain Reaction (SSP-PCR)
Take Control of Your Digestive Health
Don’t let unexplained gastrointestinal symptoms control your life. The HLA Celiac Disease DRDQB1DQA1 Haplotype Association Including DQ2DQ8 Test provides the genetic clarity needed to make informed decisions about your health. Our experienced gastroenterology specialists and genetic counselors are available to help interpret your results and develop personalized management strategies.
Ready to uncover your genetic risk for celiac disease? Book your test today by calling +1(267) 388-9828 or visit our website to schedule your appointment. Take the first step toward definitive diagnosis and personalized care.
