Histamine 24-Hour Urine Test
Comprehensive Diagnostic Assessment for Histamine-Related Disorders
The Histamine 24-Hour Urine Test represents a sophisticated diagnostic approach to evaluating histamine metabolism and mast cell function within the body. Histamine, a crucial biogenic amine, plays essential roles in immune responses, gastric acid secretion, and neurotransmission. However, excessive histamine production or impaired degradation can lead to significant health challenges requiring precise medical evaluation.
What This Advanced Test Measures
This specialized laboratory analysis quantifies histamine levels excreted in urine over a complete 24-hour collection period. The test provides:
- Accurate measurement of total histamine excretion
- Assessment of mast cell activation and degranulation
- Evaluation of histamine metabolism efficiency
- Creatinine measurement to verify proper collection completeness
- Identification of abnormal histamine production patterns
Who Should Consider This Essential Test?
Clinical Indications and Symptoms
Patients experiencing the following symptoms may benefit significantly from histamine testing:
- Chronic Unexplained Flushing: Sudden reddening of skin without apparent cause
- Recurrent Hives and Urticaria: Persistent skin reactions and welts
- Gastrointestinal Distress: Abdominal pain, diarrhea, or nausea after meals
- Systemic Allergic Reactions: Multiple chemical sensitivities or environmental allergies
- Mast Cell Activation Symptoms: Unexplained anaphylaxis-like episodes
- Headaches and Migraines: Particularly those triggered by specific foods
- Cardiovascular Symptoms: Rapid heart rate or blood pressure fluctuations
Significant Benefits of Histamine Testing
Comprehensive Diagnostic Advantages
- Accurate Diagnosis: Differentiates between various histamine-related disorders
- Treatment Guidance: Informs appropriate antihistamine therapy and dietary modifications
- Disease Monitoring: Tracks treatment effectiveness and disease progression
- Preventive Insights: Identifies triggers for future symptom avoidance
- Comprehensive Assessment: Provides broader understanding of immune system function
Understanding Your Test Results
Interpreting Histamine Levels
Your test results will provide valuable insights into your histamine metabolism:
- Normal Range: Indicates typical histamine production and elimination
- Elevated Levels: May suggest mast cell activation disorder, allergies, or histamine intolerance
- Significantly High Levels: Could indicate systemic mastocytosis or severe allergic conditions
- Low Levels: Generally not clinically significant but should be discussed with your physician
Important Note: Always consult with your healthcare provider for proper interpretation of results and personalized medical advice. Test results should be considered in the context of your complete clinical picture.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $538 |
| Regular Price | $626 |
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more cities nationwide.
Sample Collection Instructions
Proper Procedure for Accurate Results
- Collection Period: Complete 24-hour urine collection
- Sample Volume: 5 mL aliquot (minimum 3 mL) from 24-hour collection
- Preservation: Collect with 10 mL of 50% 6N HCl to maintain pH between 1-3
- Documentation: Record 24-hour volume on test request form and urine container
- Shipping: Ship refrigerated or frozen; avoid direct sunlight
- Medication Restrictions: Avoid antihistamines, oral corticosteroids, and H2 receptor blockers 24 hours prior to collection
- Required Forms: Duly filled Test Send Out Consent Form (Form 35) is mandatory
Turnaround Time and Reporting
Sample submission by the 7th of the month ensures timely processing. Comprehensive test reports are typically available within 2-3 weeks after sample receipt, providing detailed analysis and clinical insights for your healthcare provider.
Take Control of Your Health Today
Don’t let unexplained symptoms control your life. The Histamine 24-Hour Urine Test provides the clarity needed for proper diagnosis and effective treatment of histamine-related conditions. Our experienced medical team and state-of-the-art laboratory facilities ensure accurate, reliable results you can trust.
Ready to begin your diagnostic journey? Contact us now to schedule your test:
Call or WhatsApp: +1(267) 388-9828
Our compassionate healthcare professionals are available to answer your questions, discuss testing procedures, and help you take the first step toward better understanding your health. Book your Histamine 24-Hour Urine Test today and move forward with confidence in your diagnosis and treatment plan.

