HE4 Human Epididymis Protein 4 Test – Advanced Ovarian Cancer Biomarker Screening
Understanding the HE4 Human Epididymis Protein 4 Test
The HE4 Human Epididymis Protein 4 Test represents a significant advancement in ovarian cancer diagnostics, offering healthcare providers a powerful tool for early detection and monitoring of this serious gynecological condition. As a biomarker specifically associated with epithelial ovarian cancer, HE4 testing has revolutionized how medical professionals approach ovarian cancer screening and management.
Originally discovered in the epididymis tissue, the HE4 protein has proven to be an exceptionally valuable marker when elevated in serum levels. Unlike many other cancer biomarkers, HE4 demonstrates remarkable specificity for ovarian malignancies, making it an indispensable component of modern gynecological oncology practice. The test’s ability to detect ovarian cancer in its earliest stages significantly improves treatment outcomes and survival rates.
What the HE4 Test Measures and Detects
The HE4 Human Epididymis Protein 4 Test specifically measures the concentration of HE4 protein in your blood serum using advanced Chemiluminescent Microparticle Immunoassay (CMIA) technology. This sophisticated methodology ensures:
- Precise quantification of HE4 protein levels
- High sensitivity for detecting early-stage ovarian cancer
- Excellent specificity to distinguish ovarian cancer from benign conditions
- Reliable monitoring of treatment response and disease progression
HE4 levels are particularly valuable when interpreted alongside CA-125 results, as the combination provides superior diagnostic accuracy compared to either marker alone. The test detects elevated protein concentrations that may indicate the presence of epithelial ovarian cancer, even before clinical symptoms become apparent.
Who Should Consider the HE4 Test
Several patient populations benefit significantly from HE4 testing:
Primary Screening Candidates
- Women with persistent pelvic or abdominal symptoms
- Patients with unexplained bloating, pelvic pain, or urinary symptoms
- Women with family history of ovarian or breast cancer
- Individuals with known BRCA gene mutations
- Postmenopausal women with elevated CA-125 levels
Monitoring and Follow-up
- Patients undergoing ovarian cancer treatment
- Women in remission requiring surveillance
- Patients with pelvic masses of uncertain origin
- Individuals with borderline ovarian tumors
Clinical Benefits of HE4 Testing
The HE4 Human Epididymis Protein 4 Test offers numerous advantages in clinical practice:
- Early Detection Capability – Identifies ovarian cancer at more treatable stages
- Improved Diagnostic Accuracy – Enhances specificity when combined with CA-125
- Treatment Monitoring – Tracks response to therapy and detects recurrence
- Risk Assessment – Helps evaluate malignancy risk in women with pelvic masses
- Minimal Patient Burden – Simple blood draw with no special preparation required
- Rapid Results – Same-day reporting for timely clinical decisions
Understanding Your HE4 Test Results
Interpreting HE4 results requires professional medical expertise, but general guidance includes:
Normal HE4 Levels
Normal HE4 values typically fall below established cutoff points, which vary by menopausal status. Your healthcare provider will consider your age, menopausal status, and clinical presentation when interpreting results.
Elevated HE4 Levels
Increased HE4 concentrations may indicate:
- Epithelial ovarian cancer
- Other gynecological malignancies
- Certain benign conditions (less commonly)
- Require further diagnostic evaluation
Clinical Interpretation
Your physician will interpret HE4 results in the context of:
- CA-125 levels and other clinical findings
- Imaging studies and physical examination
- Patient symptoms and risk factors
- Overall clinical picture
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | HE4 Human Epididymis Protein 4 Test |
| Discount Price | $88 USD |
| Regular Price | $126 USD |
| Turnaround Time | Same Day (Sample Mon/Thu by 4 pm) |
| Sample Type | 2 mL (1 mL min.) serum from 1 SST |
| Shipping Requirements | Refrigerated or frozen |
| Preparation | No special preparation required |
| Testing Method | CMIA (Chemiluminescent Microparticle Immunoassay) |
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our network of certified collection centers ensures accessible, professional testing services wherever you are located.
Take Action for Your Health Today
Early detection of ovarian cancer can significantly impact treatment outcomes and survival rates. The HE4 Human Epididymis Protein 4 Test provides a reliable, advanced screening option for women concerned about ovarian cancer risk. With same-day results and no special preparation required, there’s no reason to delay this important health assessment.
Ready to schedule your HE4 test? Contact our dedicated healthcare team today to book your appointment or discuss your testing needs. Call or WhatsApp us at +1(267) 388-9828 to speak with a healthcare professional who can answer your questions and help you take the next step toward proactive health management.
Don’t wait until symptoms become severe – early detection through advanced biomarker testing like HE4 can make all the difference in your health journey. Trust our experienced team and state-of-the-art testing facilities to provide the accurate, timely results you need for informed healthcare decisions.
