FISH t(11;14) or LSI IGH/CCND1 Test
Comprehensive Introduction to FISH t(11;14) Testing
The FISH t(11;14) or LSI IGH/CCND1 Test represents a cutting-edge molecular diagnostic tool in modern hematology and oncology. This specialized fluorescence in situ hybridization (FISH) analysis serves as a critical diagnostic marker for identifying specific genetic abnormalities associated with lymphoid malignancies. The test’s importance lies in its ability to detect the characteristic chromosomal translocation that defines certain types of lymphoma, particularly mantle cell lymphoma, enabling precise diagnosis and appropriate treatment planning.
What the Test Measures and Detects
This advanced genetic test specifically identifies the t(11;14)(q13;q32) chromosomal translocation, which results in the fusion of the immunoglobulin heavy chain (IGH) gene on chromosome 14 with the cyclin D1 (CCND1) gene on chromosome 11. The test measures:
- Presence of IGH/CCND1 gene fusion
- Chromosomal rearrangement between chromosomes 11 and 14
- Overexpression of cyclin D1 protein
- Genetic markers for mantle cell lymphoma diagnosis
Who Should Consider This Test
This test is recommended for individuals presenting with specific clinical indications:
- Patients with unexplained lymph node enlargement
- Individuals with suspected lymphoma based on clinical presentation
- Patients with abnormal blood counts suggesting hematological malignancy
- Those with B-cell lymphoma requiring precise classification
- Individuals with symptoms including night sweats, unexplained weight loss, or persistent fatigue
- Patients requiring differential diagnosis between various lymphoma subtypes
Key Benefits of Taking the Test
Undergoing the FISH t(11;14) test provides numerous clinical advantages:
- Definitive Diagnosis: Confirms or rules out mantle cell lymphoma with high accuracy
- Treatment Guidance: Helps oncologists select appropriate targeted therapies
- Prognostic Information: Provides insights into disease behavior and expected outcomes
- Monitoring Tool: Enables tracking of treatment response and disease progression
- Personalized Medicine: Supports development of individualized treatment plans
- Early Detection: Facilitates timely intervention for better patient outcomes
Understanding Your Test Results
Interpreting FISH t(11;14) results requires professional medical expertise, but general guidance includes:
- Positive Result: Indicates presence of IGH/CCND1 fusion, typically confirming mantle cell lymphoma diagnosis
- Negative Result: Suggests absence of the specific translocation, helping rule out certain lymphoma subtypes
- Consultation Required: All results should be discussed with your hematologist or oncologist
- Clinical Correlation: Results are interpreted in context with other clinical and laboratory findings
- Treatment Implications: Positive findings may influence chemotherapy choices and targeted therapy options
Test Pricing Information
| Test Name | Discount Price | Regular Price |
|---|---|---|
| FISH t(11;14) or LSI IGH/CCND1 Test | $150 USD | $188 USD |
Nationwide Testing Availability
We have diagnostic branches conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures accessible, high-quality genetic testing services nationwide.
Book Your Test Today
Take the first step toward accurate diagnosis and effective treatment planning. Our experienced team of genetic specialists and state-of-the-art laboratory facilities ensure reliable results and comprehensive support throughout your testing journey.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your FISH t(11;14) test and receive professional genetic counseling.
Test Specifications
- Turnaround Time: Sample accepted daily by 4 pm; Report delivered in 4 working days
- Sample Type: 5 mL (3 mL minimum) whole blood OR 4 mL (2 mL minimum) Bone Marrow from 2 Green Top (Sodium Heparin) tubes
- Shipping Instructions: Ship at 18-22°C. DO NOT FREEZE
- Required Documentation: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory
