FISH Synovial Sarcoma SS18 SYT 18q11.2 Gene Rearrangement Test
Understanding Synovial Sarcoma Genetic Testing
The FISH Synovial Sarcoma SS18 SYT 18q11.2 Gene Rearrangement Test represents a breakthrough in molecular diagnostics for soft tissue tumors. This specialized cytogenetic analysis plays a crucial role in accurately identifying synovial sarcoma, a rare but aggressive form of cancer that primarily affects young adults. The test’s precision in detecting specific genetic abnormalities makes it an indispensable tool for oncologists and pathologists in establishing definitive diagnoses and guiding appropriate treatment strategies.
What This Test Measures and Detects
This advanced diagnostic test specifically targets the characteristic chromosomal translocation that defines synovial sarcoma:
- Detection of t(X;18)(p11.2;q11.2) chromosomal translocation
- Identification of SS18-SSX gene fusion (SYT-SSX fusion)
- Analysis of SS18 (SYT) gene rearrangement on chromosome 18q11.2
- Confirmation of synovial sarcoma-specific genetic signature
The test utilizes Fluorescence In Situ Hybridization (FISH) technology, which employs fluorescent DNA probes that bind to specific chromosomal regions. When the SS18 gene is rearranged due to the characteristic translocation, the FISH signals appear separated or rearranged, providing visual confirmation of the genetic abnormality.
Who Should Consider This Test
Clinical Indications and Symptoms
This test is recommended for patients presenting with:
- Soft tissue masses with suspicious imaging characteristics
- Tumors in extremities, particularly around joints
- Young adults (15-40 years) with unexplained soft tissue growths
- Cases where initial biopsy results are inconclusive
- Patients with recurrent soft tissue tumors
- Suspected monophasic or biphasic synovial sarcoma patterns
Benefits of Taking the FISH Synovial Sarcoma Test
Choosing this specialized genetic test offers numerous advantages for patients and healthcare providers:
- Accurate Diagnosis: Provides definitive confirmation of synovial sarcoma, eliminating diagnostic uncertainty
- Treatment Guidance: Helps oncologists develop targeted treatment plans based on molecular findings
- Prognostic Information: Different genetic fusion types (SS18-SSX1 vs SS18-SSX2) may influence disease behavior
- Differential Diagnosis: Distinguishes synovial sarcoma from other soft tissue sarcomas with similar histological features
- Minimally Invasive: Requires only formalin-fixed paraffin-embedded tissue from previous biopsies
Understanding Your Test Results
Interpretation Guidelines
Your test results will provide clear information about the presence or absence of the SS18 gene rearrangement:
Positive Result
A positive result indicates detection of the SS18-SSX gene fusion, confirming the diagnosis of synovial sarcoma. This finding:
- Provides definitive diagnostic confirmation
- Supports appropriate treatment planning
- May help predict response to certain therapies
Negative Result
A negative result suggests the absence of the characteristic SS18 rearrangement, which:
- May indicate a different type of soft tissue tumor
- Requires consideration of alternative diagnoses
- Should be interpreted in clinical context with other findings
Inconclusive Result
In some cases, technical factors or sample quality may lead to inconclusive results, necessitating:
- Repeat testing if adequate tissue is available
- Consideration of alternative diagnostic methods
- Clinical correlation with other findings
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $300 |
| Regular Price | $450 |
Turnaround Time and Sample Requirements
Turnaround Time: Samples accepted daily by 4 PM; Reports delivered within 4 working days
Sample Type: Formalin fixed paraffin embedded tissue block containing at least 10% tumor tissue
Shipping: Ship at room temperature with completed Chromosome & FISH analysis Requisition Form (Form 17)
Nationwide Availability
We have diagnostic centers conveniently located across the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network ensures accessible, high-quality genetic testing services nationwide.
Take Action for Your Health
Don’t leave your diagnosis to chance. The FISH Synovial Sarcoma SS18 SYT 18q11.2 Gene Rearrangement Test provides the clarity and confidence needed for effective cancer management. Early and accurate diagnosis is crucial for optimal treatment outcomes.
Ready to schedule your test? Contact us today:
Call or WhatsApp: +1(267) 388-9828
Our genetic specialists are available to answer your questions and help you understand the testing process. Take the first step toward definitive diagnosis and personalized treatment planning.
