FISH RARA 17q21 Variant Translocation Test
Comprehensive Genetic Testing for Acute Promyelocytic Leukemia
The FISH RARA 17q21 Variant Translocation Test represents a cutting-edge diagnostic approach in cancer genetics, specifically designed to detect chromosomal abnormalities associated with acute promyelocytic leukemia (APL). This sophisticated genetic analysis plays a crucial role in modern hematology and oncology practice, providing essential information for accurate diagnosis and targeted treatment planning.
What This Test Measures and Detects
This specialized FISH (Fluorescence In Situ Hybridization) test specifically targets the RARA (Retinoic Acid Receptor Alpha) gene located on chromosome 17 at position q21. The test identifies:
- Translocation events involving the RARA gene
- Variant chromosomal rearrangements beyond the classic t(15;17) translocation
- Genetic abnormalities that may affect treatment response
- Specific breakpoints and fusion gene formations
The detection of RARA gene translocations is particularly significant because these genetic alterations disrupt normal cellular differentiation and contribute to the development of APL, a distinct subtype of acute myeloid leukemia.
Who Should Consider This Test
This genetic test is recommended for individuals presenting with:
- Suspected or newly diagnosed acute promyelocytic leukemia
- Unexplained bleeding tendencies or coagulation abnormalities
- Abnormal blood counts with promyelocyte presence
- Patients with APL who may have variant translocations
- Individuals requiring confirmation of APL diagnosis before treatment initiation
- Patients with treatment-resistant leukemia cases
Clinical Benefits and Importance
Undergoing the FISH RARA 17q21 Variant Translocation Test provides numerous clinical advantages:
- Accurate Diagnosis: Confirms APL diagnosis with high specificity and sensitivity
- Treatment Guidance: Determines eligibility for targeted therapies like ATRA
- Prognostic Information: Helps assess disease severity and potential treatment response
- Monitoring Capability: Enables tracking of minimal residual disease
- Personalized Medicine: Supports development of individualized treatment plans
Understanding Your Test Results
Your FISH RARA 17q21 Variant Translocation Test results will be interpreted by our expert genetic specialists:
- Positive Result: Indicates the presence of RARA gene translocation, confirming APL diagnosis and guiding targeted therapy selection
- Negative Result: Suggests absence of the specific translocation, potentially indicating other leukemia subtypes
- Variant Findings: May reveal unusual translocation patterns requiring specialized interpretation
- Quantitative Data: Provides information about the percentage of abnormal cells detected
All results are accompanied by detailed clinical interpretation and recommendations from our board-certified genetic counselors and hematologists.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $150 |
| Regular Price | $188 |
Nationwide Accessibility
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, Austin, Jacksonville, Fort Worth, Columbus, Charlotte, San Francisco, Indianapolis, Seattle, Denver, Washington DC, Boston, El Paso, Nashville, Detroit, Oklahoma City, Portland, Las Vegas, Memphis, Louisville, Baltimore, and Milwaukee.
Sample Requirements and Processing
Turnaround Time: Samples accepted daily by 4 pm; Reports delivered within 4 days
Sample Type: 5 mL (3 mL minimum) whole blood OR 4 mL (2 mL minimum) Bone Marrow from 2 Green Top (Sodium Heparin) tubes
Shipping Instructions: Ship at 18-22°C. DO NOT FREEZE
Required Documentation: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory
Take Action for Your Health
Don’t delay critical genetic testing that could significantly impact your treatment journey. Our expert team of genetic specialists, hematologists, and oncologists are ready to provide comprehensive genetic analysis and personalized guidance.
Book your FISH RARA 17q21 Variant Translocation Test today by calling our dedicated healthcare line at +1(267) 388-9828 or schedule your appointment online. Take the first step toward accurate diagnosis and targeted treatment planning with our state-of-the-art genetic testing services.
