FISH EGFR Gene Amplification Test
Comprehensive Introduction to EGFR Gene Testing
The FISH EGFR Gene Amplification Test represents a cutting-edge molecular diagnostic approach that utilizes Fluorescence In Situ Hybridization (FISH) technology to detect abnormalities in the Epidermal Growth Factor Receptor (EGFR) gene. This sophisticated genetic analysis plays a pivotal role in modern oncology by identifying specific genetic alterations that drive cancer progression and influence treatment response.
EGFR is a critical cell surface receptor that regulates cell growth, division, and survival. When amplified or mutated, this gene can become a powerful driver of uncontrolled cell proliferation, contributing to the development and progression of various cancers. The FISH EGFR test provides clinicians with essential genetic information that directly impacts therapeutic decisions and patient management strategies.
What the FISH EGFR Test Measures and Detects
This advanced genetic test specifically identifies:
- EGFR gene amplification – abnormal increases in gene copy number
- Chromosomal rearrangements involving the EGFR locus
- Gene copy number variations that may predict treatment response
- Genetic abnormalities that qualify patients for targeted therapies
The FISH methodology employs fluorescent DNA probes that bind specifically to the EGFR gene region on chromosome 7. Under specialized microscopy, these probes reveal the precise number and location of EGFR genes within tumor cells, providing a visual representation of genetic status that informs clinical decision-making.
Who Should Consider EGFR Gene Amplification Testing
Clinical Indications and Patient Profiles
This test is particularly recommended for patients with:
- Non-small cell lung cancer (NSCLC) being evaluated for EGFR-targeted therapy
- Glioblastoma multiforme requiring comprehensive genetic profiling
- Head and neck squamous cell carcinomas
- Colorectal cancers with potential EGFR pathway involvement
- Patients with treatment-resistant cancers requiring alternative therapeutic options
- Individuals with family history of EGFR-related malignancies
Symptoms and Clinical Presentations
Patients experiencing persistent respiratory symptoms, unexplained neurological changes, or those diagnosed with solid tumors may benefit from EGFR genetic analysis to guide personalized treatment approaches.
Significant Benefits of EGFR Gene Testing
Undergoing FISH EGFR Gene Amplification testing provides numerous clinical advantages:
- Personalized Treatment Planning: Identifies patients likely to respond to EGFR inhibitors
- Therapy Selection Guidance: Helps oncologists choose between conventional chemotherapy and targeted treatments
- Improved Outcomes: Enables more effective, targeted therapeutic interventions
- Reduced Side Effects: Avoids unnecessary treatments in patients unlikely to benefit
- Prognostic Information: Provides insights into disease progression and potential outcomes
- Cost-Effective Care: Directs healthcare resources toward treatments with higher likelihood of success
Understanding Your Test Results
Interpretation Guidelines
Your FISH EGFR Gene Amplification test results will be carefully analyzed and interpreted by our expert cytogeneticists:
- Positive for Amplification: Indicates increased EGFR gene copies, suggesting potential responsiveness to EGFR-targeted therapies
- Negative for Amplification: Normal gene copy number, may indicate alternative treatment approaches
- Borderline Results: May require additional testing or clinical correlation
- Technical Considerations: Results depend on adequate tumor tissue sampling and proper specimen handling
All results include detailed interpretation by board-certified genetic specialists and are presented in a comprehensive report format suitable for clinical decision-making. Your healthcare provider will discuss the implications of your results and develop an appropriate treatment plan based on the genetic findings.
Test Pricing and Service Details
| Service Description | Price (USD) |
|---|---|
| FISH EGFR Gene Amplification Test – Discount Price | $300 |
| FISH EGFR Gene Amplification Test – Regular Price | $450 |
| Turnaround Time: Sample Daily by 4 pm; Report 4 Working Days | |
| Sample Type: Formalin fixed paraffin embedded tissue block with 10% tumor tissue | |
Nationwide Testing Availability
GGC DNA maintains comprehensive testing facilities across the United States, with convenient locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our nationwide network ensures accessible genetic testing services for patients and healthcare providers throughout the country.
Schedule Your Genetic Test Today
Take the next step in personalized cancer care with our advanced FISH EGFR Gene Amplification testing. Our experienced genetic counselors and oncology specialists are available to answer your questions and guide you through the testing process.
Call or WhatsApp: +1(267) 388-9828
Service Hours: Monday – Friday, 8:00 AM – 6:00 PM EST
Don’t delay critical genetic information that could transform your cancer treatment journey. Contact us today to schedule your FISH EGFR Gene Amplification test and take control of your healthcare decisions with confidence and clarity.
