FISH BCR-ABL or Philadelphia Translocation Test
Understanding the FISH BCR-ABL Philadelphia Translocation Test
The FISH BCR-ABL Philadelphia Translocation Test represents a cornerstone in modern hematological diagnostics, specifically designed to detect one of the most significant genetic abnormalities in cancer medicine. This sophisticated cytogenetic analysis identifies the presence of the Philadelphia chromosome, a hallmark genetic alteration found in approximately 95% of Chronic Myeloid Leukemia (CML) cases and some cases of Acute Lymphoblastic Leukemia (ALL).
This test utilizes Fluorescence In Situ Hybridization (FISH) technology, which employs fluorescent DNA probes that bind specifically to the BCR and ABL genes. When these genes are in their normal positions on chromosomes 22 and 9 respectively, the fluorescent signals appear separate. However, when the Philadelphia translocation occurs, the signals merge, indicating the presence of the abnormal BCR-ABL fusion gene that drives uncontrolled white blood cell production.
What the Test Measures and Detects
The FISH BCR-ABL test specifically identifies:
- The presence of the Philadelphia chromosome translocation t(9;22)
- The BCR-ABL fusion gene formation
- The percentage of cells carrying this genetic abnormality
- Response to targeted therapy monitoring
- Minimal residual disease detection
This test provides both qualitative (presence/absence) and quantitative (percentage of positive cells) information, making it invaluable for both initial diagnosis and ongoing treatment monitoring. The sensitivity of FISH testing allows detection of the Philadelphia chromosome in as few as 1-2% of cells, providing crucial early detection capabilities.
Who Should Consider This Test
Clinical Indications and Symptoms
This test is recommended for individuals presenting with:
- Unexplained elevated white blood cell counts
- Symptoms suggestive of chronic myeloid leukemia
- Enlarged spleen (splenomegaly)
- Fatigue, night sweats, and unexplained weight loss
- Abnormal blood counts detected during routine examinations
- Family history of hematological malignancies
- Patients already diagnosed with CML for treatment monitoring
Oncologists and hematologists typically order this test when clinical symptoms or blood work suggest possible CML. The test is also crucial for patients undergoing tyrosine kinase inhibitor therapy to monitor treatment effectiveness and detect potential resistance.
Benefits of Taking the FISH BCR-ABL Test
Undergoing this specialized genetic testing provides numerous advantages:
- Accurate Diagnosis: Provides definitive confirmation of Philadelphia chromosome presence
- Early Detection: Identifies genetic abnormalities before full disease manifestation
- Treatment Guidance: Helps determine appropriate targeted therapy options
- Monitoring Capability: Tracks treatment response and disease progression
- Prognostic Information: Provides insights into disease course and outcomes
- Minimal Residual Disease Detection: Identifies low levels of persistent disease
Understanding Your Test Results
Interpreting FISH BCR-ABL test results requires professional medical expertise, but general guidance includes:
Positive Result
A positive result indicates the presence of the Philadelphia chromosome and confirms the diagnosis of CML or Philadelphia-positive ALL. The percentage of positive cells helps determine disease burden and monitor treatment response over time.
Negative Result
A negative result suggests the absence of the Philadelphia chromosome, which may indicate either the absence of CML or the presence of Philadelphia-negative leukemia variants requiring different diagnostic approaches.
Quantitative Results
The percentage of cells showing the Philadelphia translocation provides valuable information about disease progression and treatment effectiveness. Decreasing percentages typically indicate positive response to therapy.
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $150 |
| Regular Price | $200 |
Turnaround Time
Samples accepted daily until 4:00 PM | Reports delivered within 4 working days
Sample Requirements
5 mL (3 mL minimum) whole blood OR 4 mL (2 mL minimum) Bone Marrow collected in 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our network of certified cytogenetics laboratories ensures consistent, high-quality testing standards nationwide.
Book Your Test Today
Take control of your health with precise genetic testing. Our specialized FISH BCR-ABL Philadelphia Translocation Test provides the critical information needed for accurate diagnosis and effective treatment planning. Contact our genetic counseling team to schedule your test or discuss your testing needs.
Call or WhatsApp: +1(267) 388-9828
Our experienced genetic specialists are available to answer your questions, provide pre-test counseling, and ensure you receive the comprehensive care and support you deserve throughout the testing process.
