Factor XIII Clot Solubility Functional Qualitative Test
Understanding Factor XIII Clot Solubility Testing
The Factor XIII Clot Solubility Functional Qualitative Test represents a sophisticated diagnostic approach to evaluating blood coagulation stability. This essential hematological assessment specifically examines the functional integrity of Factor XIII, a crucial transglutaminase enzyme that plays a vital role in the final stages of the coagulation cascade. When blood clots form, Factor XIII cross-links fibrin strands, creating a stable, durable clot that resists premature dissolution and provides effective hemostasis.
What This Test Measures and Detects
This specialized coagulation test employs the Clot Dissolution method with 5M Urea to assess the qualitative functionality of Factor XIII. The test specifically measures:
- Clot stability and resistance to chemical dissolution
- Functional activity of Factor XIII enzyme
- Proper cross-linking of fibrin polymers
- Overall clot integrity and durability
The principle involves observing whether formed blood clots dissolve when exposed to urea solution. Normal clots with adequate Factor XIII activity remain stable, while deficient clots dissolve rapidly, indicating potential bleeding disorders.
Who Should Consider This Test
This diagnostic evaluation is particularly important for individuals experiencing:
- Unexplained or excessive bleeding episodes
- Delayed wound healing beyond normal expectations
- Abnormal bruising without significant trauma
- Family history of bleeding disorders
- Post-surgical bleeding complications
- Menorrhagia or heavy menstrual bleeding
- Neonatal bleeding manifestations
- Suspected congenital coagulation deficiencies
Clinical Indications and Symptoms
Patients presenting with recurrent bleeding from minor injuries, spontaneous joint bleeding, or intracranial hemorrhage should strongly consider this evaluation. The test is particularly valuable when routine coagulation screening tests (PT, aPTT) appear normal despite clinical bleeding symptoms.
Benefits of Taking the Factor XIII Test
Undergoing this comprehensive diagnostic assessment provides numerous advantages:
- Accurate Diagnosis: Precisely identifies Factor XIII deficiencies that might be missed by standard coagulation panels
- Treatment Guidance: Helps hematologists develop targeted treatment strategies including Factor XIII replacement therapy
- Risk Assessment: Evaluates bleeding risk before surgical procedures or dental work
- Genetic Counseling: Provides valuable information for family planning when hereditary disorders are suspected
- Monitoring Capability: Enables tracking of treatment effectiveness in known Factor XIII deficiency cases
Understanding Your Test Results
Interpreting Factor XIII Clot Solubility results requires professional medical expertise, but general guidance includes:
Normal Results
Clots that remain intact in urea solution for the designated observation period indicate normal Factor XIII activity. This suggests adequate clot stabilization and reduced bleeding risk.
Abnormal Results
Rapid clot dissolution typically indicates Factor XIII deficiency. This may represent congenital deficiency (rare) or acquired conditions affecting Factor XIII levels. Further quantitative testing and hematology consultation are recommended for abnormal findings.
Clinical Correlation
Results should always be interpreted in the context of clinical symptoms, medical history, and other laboratory findings. Your healthcare provider will explain the implications and recommend appropriate next steps.
Test Information and Pricing
| Test Component | Details |
|---|---|
| Test Name | Factor XIII Clot Solubility Functional Qualitative Test |
| Discount Price | $10 USD |
| Regular Price | $12 USD |
| Turnaround Time | Sample Daily by 1 pm; Report Next Day |
| Sample Type | 3 mL whole blood in 1 Blue Top (Sodium Citrate) tube |
| Methodology | Clot Dissolution with 5M Urea |
Sample Collection Instructions
Proper sample handling is crucial for accurate results:
- Collect 3 mL whole blood in sodium citrate tube
- Mix thoroughly by gentle inversion
- Transport to laboratory within 4 hours
- Overnight fasting is preferred
- Complete Coagulation Requisition Form (Form 15)
- Discuss medication adjustments with your physician
Nationwide Testing Availability
We proudly serve patients across the United States with convenient testing locations in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art laboratories ensure consistent, reliable results regardless of location.
Take Action for Your Health
Don’t let unexplained bleeding symptoms go unaddressed. The Factor XIII Clot Solubility Functional Qualitative Test provides critical insights into your coagulation health. Our experienced hematology team is ready to help you understand your bleeding risks and develop appropriate management strategies.
Book your Factor XIII test today by calling +1(267) 388-9828 or schedule your appointment online. Take the first step toward comprehensive coagulation assessment and peace of mind.
