Desmoglein DSG 1 and 3 Antibody in Dilution End Point Titre Test
Understanding Autoimmune Skin Disorders
Autoimmune blistering diseases represent a group of serious conditions where the body’s immune system mistakenly attacks healthy skin cells. The Desmoglein DSG 1 and 3 Antibody Test serves as a critical diagnostic tool in identifying these disorders, particularly pemphigus variants that can significantly impact quality of life and require specialized medical management.
What This Test Measures
This specialized immunopathology test detects and quantifies autoantibodies directed against desmoglein 1 and desmoglein 3 proteins. These proteins are essential components of desmosomes – the cellular structures that maintain skin integrity by holding skin cells together. When antibodies attack these proteins, they disrupt cell-to-cell adhesion, leading to the characteristic blistering and erosion seen in pemphigus disorders.
Key Measurements Include:
- Desmoglein 1 antibody levels
- Desmoglein 3 antibody levels
- Quantitative antibody titration
- Disease activity correlation
Who Should Consider This Test?
This test is particularly important for individuals experiencing symptoms suggestive of autoimmune blistering disorders. Consult your dermatologist if you notice:
Common Symptoms:
- Painful blisters or erosions on skin and mucous membranes
- Oral ulcers that don’t heal properly
- Fragile skin that shears easily with minor trauma
- Persistent scalp lesions or hair loss
- Nail abnormalities and bed separation
- Generalized skin involvement with fluid-filled blisters
Clinical Benefits of Testing
Early and accurate diagnosis through Desmoglein antibody testing provides numerous advantages for patient care and treatment outcomes.
Primary Benefits:
- Definitive Diagnosis: Confirms or rules out pemphigus disorders
- Disease Monitoring: Tracks treatment response and disease activity
- Treatment Guidance: Helps optimize immunosuppressive therapy
- Prognostic Information: Correlates antibody levels with disease severity
- Early Intervention: Enables prompt treatment to prevent complications
Understanding Your Test Results
Your test results will provide quantitative measurements of Desmoglein 1 and 3 antibody levels. Higher antibody titers typically correlate with more active disease, while decreasing levels often indicate successful treatment response. Your dermatologist will interpret these results in the context of your clinical presentation and symptoms.
Result Interpretation Guidelines:
- Positive DSG1: Suggests pemphigus foliaceus
- Positive DSG3: Indicates pemphigus vulgaris
- Both Positive: Typically pemphigus vulgaris
- Negative Results: May rule out pemphigus or suggest other blistering disorders
Test Pricing Information
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $300 |
| Regular Price | $450 |
Convenient Testing Locations Nationwide
We have branches across all major cities in the USA, including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, and San Jose. Our state-of-the-art facilities ensure accurate testing with rapid turnaround times.
Testing Details:
- Sample Requirements: 2 mL (1 mL minimum) serum from 1 SST
- Shipping: Refrigerated or frozen overnight
- Fasting: Overnight fasting preferred
- Turnaround: Sample Tuesday/Friday by 9 AM; Report in 3 days
- Methodology: Immunofluorescence Assay (IFA)
Take Control of Your Skin Health Today
Don’t let unexplained blistering or skin lesions go undiagnosed. Our Desmoglein DSG 1 and 3 Antibody Test provides the clarity you need for proper diagnosis and treatment. With convenient locations nationwide and expert interpretation, we make specialized autoimmune testing accessible to everyone.
Ready to get answers? Book your test today by calling +1(267) 388-9828 or schedule your appointment online. Our team is ready to help you take the first step toward better skin health and peace of mind.
