Cortisol Suppression by Dexamethasone Overnight High Dose Test
Comprehensive Adrenal Function Assessment
The Cortisol Suppression by Dexamethasone Overnight High Dose Test represents a sophisticated diagnostic approach for evaluating adrenal gland function and detecting disorders of cortisol regulation. This specialized test provides crucial insights into the hypothalamic-pituitary-adrenal (HPA) axis, which governs the body’s stress response and cortisol production. By administering a high dose of dexamethasone and measuring subsequent cortisol levels, healthcare providers can accurately assess whether the adrenal glands are functioning normally or producing excessive cortisol.
What This Test Measures and Detects
This diagnostic procedure specifically measures:
- Baseline cortisol levels before dexamethasone administration
- Post-dexamethasone cortisol suppression response
- Adrenal gland responsiveness to synthetic glucocorticoids
- HPA axis integrity and regulatory mechanisms
- Potential autonomous cortisol production
The test detects abnormalities in cortisol regulation that may indicate Cushing’s syndrome, adrenal tumors, pituitary disorders, or other endocrine conditions affecting cortisol production. The high-dose dexamethasone protocol helps differentiate between various causes of cortisol excess, providing essential diagnostic information for treatment planning.
Who Should Consider This Test
This test is recommended for individuals experiencing symptoms suggestive of cortisol imbalance or adrenal dysfunction:
Clinical Indications and Symptoms
- Unexplained weight gain, particularly in the face, neck, and trunk
- Persistent high blood pressure that doesn’t respond to conventional treatment
- New-onset diabetes or worsening glucose control
- Muscle weakness and fatigue
- Thinning skin with easy bruising
- Purple stretch marks on abdomen, thighs, and arms
- Mood changes, including depression and anxiety
- Irregular menstrual cycles in women
- Decreased libido and fertility issues
- Osteoporosis or frequent bone fractures
Benefits of Taking the Cortisol Suppression Test
Early Detection and Accurate Diagnosis
This test offers numerous advantages for patients and healthcare providers:
- Early Intervention: Detects adrenal disorders before they cause significant complications
- Precise Diagnosis: Differentiates between various causes of cortisol excess
- Treatment Guidance: Provides essential information for developing targeted treatment plans
- Monitoring Tool: Helps track treatment effectiveness for adrenal conditions
- Comprehensive Assessment: Evaluates multiple aspects of adrenal function simultaneously
Understanding Your Test Results
Interpreting Cortisol Suppression Patterns
Your test results will show how your cortisol levels responded to dexamethasone administration:
- Normal Suppression: Cortisol levels decrease significantly after dexamethasone, indicating normal HPA axis function
- Partial Suppression: Moderate cortisol reduction may suggest pituitary-dependent Cushing’s disease
- No Suppression: Persistent high cortisol levels typically indicate adrenal tumors or ectopic ACTH production
- Exaggerated Suppression: Unusually low cortisol levels may suggest adrenal insufficiency
Your healthcare provider will interpret these results in the context of your symptoms, medical history, and other diagnostic findings to determine the appropriate course of action.
Test Procedure and Preparation
Step-by-Step Testing Protocol
The Cortisol Suppression by Dexamethasone Overnight High Dose Test follows a specific two-day protocol:
- Day 1 – Baseline Sample: Visit our facility at 8 AM for fasting blood draw to measure baseline cortisol levels
- Medication Administration: Take the 4 mg dexamethasone tablet orally at 11 PM the same night
- Day 2 – Post-Medication Sample: Return at 8 AM the next morning for the second blood draw
- Sample Processing: Both samples are analyzed using advanced chemiluminescent immunoassay technology
Important Pre-Test Instructions
- Fast before the baseline blood draw at 8 AM
- Do not take any steroid medications before the test
- Inform your healthcare provider about all current medications
- Follow the exact timing for medication administration and blood draws
- Maintain normal activities between samples unless otherwise instructed
Test Pricing and Availability
| Test Name | Discount Price | Regular Price |
|---|---|---|
| Cortisol Suppression by Dexamethasone Overnight High Dose Test | $32 USD | $36 USD |
Nationwide Testing Availability
We have diagnostic centers conveniently located throughout the United States, including major metropolitan areas:
- New York City and surrounding areas
- Los Angeles and Southern California
- Chicago and Midwest regions
- Houston and Texas locations
- Phoenix and Arizona facilities
- All other major cities across the USA
Our state-of-the-art laboratories utilize advanced chemiluminescent immunoassay technology to ensure accurate and reliable results with daily turnaround times.
Take Control of Your Adrenal Health Today
Don’t let unexplained symptoms affect your quality of life. The Cortisol Suppression by Dexamethasone Overnight High Dose Test provides the comprehensive assessment needed to understand your adrenal function and identify potential disorders. With our affordable pricing at only $32 and convenient locations nationwide, getting the answers you need has never been easier.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your test or speak with our endocrine specialists about your symptoms and testing options.
Early detection of adrenal disorders can significantly improve treatment outcomes and quality of life. Trust our experienced team and advanced diagnostic capabilities to provide the accurate information you need for optimal health management.
