Androstenedione Stimulation by ACTH Test
Understanding the Androstenedione Stimulation Test
The Androstenedione Stimulation by ACTH Test represents a sophisticated diagnostic approach for evaluating adrenal gland function and hormonal regulation. This specialized procedure measures how the adrenal cortex responds to adrenocorticotropic hormone (ACTH) stimulation by tracking changes in androstenedione levels. As a key intermediate steroid in the androgen biosynthesis pathway, androstenedione serves as a crucial biomarker for assessing adrenal steroidogenesis and identifying potential endocrine disorders.
Scientific Basis and Clinical Significance
This test operates on the fundamental principle that healthy adrenal glands should demonstrate a predictable response to ACTH stimulation. When synthetic ACTH (Synacthen) is administered intravenously, it triggers the adrenal cortex to produce and release various steroid hormones, including androstenedione. By measuring baseline and stimulated levels, clinicians can evaluate the functional capacity of the adrenal glands and detect abnormalities in steroid hormone production pathways.
What the Test Measures and Detects
The Androstenedione Stimulation by ACTH Test specifically evaluates:
- Baseline androstenedione levels before ACTH administration
- Stimulated androstenedione levels 90 minutes after ACTH injection
- Adrenal cortex responsiveness to ACTH stimulation
- Functional capacity of steroidogenesis pathways
- Potential enzymatic deficiencies in adrenal hormone production
Clinical Applications
This diagnostic procedure is particularly valuable for detecting congenital adrenal hyperplasia (CAH), adrenal insufficiency, adrenal tumors, and various disorders affecting adrenal androgen production. The test helps differentiate between different types of adrenal disorders and provides essential information for treatment planning and monitoring.
Who Should Consider This Test
This specialized diagnostic test is recommended for individuals experiencing:
- Unexplained hirsutism or excessive hair growth in women
- Menstrual irregularities or fertility concerns
- Signs of virilization in females
- Suspected congenital adrenal hyperplasia
- Adrenal insufficiency symptoms including fatigue and weakness
- Unexplained weight changes and electrolyte imbalances
- Monitoring adrenal function during treatment for adrenal disorders
- Evaluation of ambiguous genitalia in newborns
Risk Factors and Indications
Patients with family history of adrenal disorders, those with autoimmune conditions affecting endocrine function, and individuals showing signs of androgen excess should consider this comprehensive evaluation. The test is also valuable for monitoring treatment effectiveness in diagnosed adrenal conditions.
Benefits of Taking the Androstenedione Stimulation Test
Undergoing this specialized diagnostic procedure offers numerous advantages:
- Accurate Diagnosis: Provides precise assessment of adrenal function and hormone production capabilities
- Early Detection: Identifies adrenal disorders before they progress to more serious complications
- Treatment Guidance: Informs appropriate therapeutic interventions based on specific adrenal responses
- Comprehensive Evaluation: Offers detailed insights into steroidogenesis pathways and adrenal cortex function
- Monitoring Capability: Enables tracking of treatment effectiveness and disease progression
- Differential Diagnosis: Helps distinguish between various adrenal disorders with similar symptoms
Clinical Value
The test provides clinicians with essential data for making informed treatment decisions, particularly in complex endocrine cases where standard hormone measurements may not provide sufficient diagnostic clarity.
Understanding Your Test Results
Interpreting Androstenedione Stimulation Test results requires careful consideration of multiple factors:
Normal Response Patterns
A healthy adrenal response typically shows a significant increase in androstenedione levels following ACTH stimulation. The expected response pattern varies based on age, sex, and individual physiological factors. Your healthcare provider will compare your results to established reference ranges and consider your specific clinical context.
Abnormal Findings and Their Implications
- Blunted Response: May indicate adrenal insufficiency or enzymatic defects in steroidogenesis
- Exaggerated Response: Could suggest congenital adrenal hyperplasia or adrenal tumors
- No Significant Change: May point to complete adrenal failure or severe enzymatic deficiencies
- Pattern Analysis: The specific pattern of response helps differentiate between various adrenal disorders
Clinical Correlation
Results should always be interpreted in conjunction with clinical symptoms, medical history, and other laboratory findings. Your endocrinologist will provide comprehensive analysis and explain what your specific results mean for your health and treatment plan.
Test Pricing and Availability
| Test Description | Price (USD) |
|---|---|
| Androstenedione Stimulation by ACTH Test | $176 USD |
| Discount Price | $126 USD |
Test Specifications
- Turnaround Time: Sample collection Monday/Thursday by 4 PM; Same-day reporting
- Sample Type: 3 mL (1.5 mL minimum) serum from 1 SST for each timed specimen
- Methodology: Chemiluminescent Immunoassay
- Specialty: Endocrinology
- Disease Focus: Disorders of Adrenal Gland
Convenient Testing Locations Across the USA
GGC DNA maintains comprehensive testing facilities throughout major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other locations. Our nationwide network ensures accessible, high-quality diagnostic services for patients across the United States.
Professional Expertise
Our testing is performed by experienced endocrinology specialists using state-of-the-art chemiluminescent immunoassay technology. We maintain the highest standards of accuracy and reliability in all our diagnostic procedures.
Take Control of Your Adrenal Health Today
Don’t let unexplained symptoms compromise your quality of life. The Androstenedione Stimulation by ACTH Test provides the comprehensive evaluation needed to understand your adrenal function and address potential endocrine disorders. With our discounted price of $126 USD and convenient locations across the country, there’s never been a better time to prioritize your endocrine health.
Ready to schedule your test? Contact our dedicated healthcare team today at +1(267) 388-9828 or book your appointment online. Our specialists are available to answer your questions and guide you through the testing process.
Take the first step toward understanding your adrenal health and achieving optimal endocrine function. Book your Androstenedione Stimulation by ACTH Test now and benefit from our expert analysis and comprehensive diagnostic capabilities.
