ANCA Anti-Neutrophil Cytoplasmic Antibodies Positive Reflex to ANCA MPO and ANCA PR3 Test
Comprehensive Autoimmune Vasculitis Detection
The ANCA Anti-Neutrophil Cytoplasmic Antibodies Positive Reflex to ANCA MPO and ANCA PR3 Test represents a sophisticated diagnostic approach for identifying autoimmune vasculitis disorders. This advanced immunological assessment plays a crucial role in detecting and differentiating various forms of systemic vasculitis, enabling healthcare providers to make accurate diagnoses and implement targeted treatment strategies.
What Does This Test Measure?
This comprehensive panel evaluates three critical components of autoimmune vasculitis:
- ANCA Antibodies (Immunofluorescence Assay): Detects the presence and pattern of anti-neutrophil cytoplasmic antibodies
- ANCA-MPO (Myeloperoxidase): Measures antibodies against myeloperoxidase enzyme
- ANCA-PR3 (Proteinase 3): Assesses antibodies targeting proteinase 3 enzyme
Clinical Importance and Applications
The ANCA test serves as a cornerstone in autoimmune disease diagnosis, particularly for:
- Granulomatosis with Polyangiitis (GPA)
- Microscopic Polyangiitis (MPA)
- Eosinophilic Granulomatosis with Polyangiitis (EGPA)
- Renal-limited vasculitis
- Monitoring disease activity and treatment response
Who Should Consider ANCA Testing?
This test is recommended for individuals experiencing symptoms suggestive of systemic autoimmune vasculitis:
Common Symptoms and Clinical Presentations
- Unexplained fever, fatigue, and weight loss
- Persistent sinusitis, nasal crusting, or epistaxis
- Joint pain and swelling without clear cause
- Skin rashes, ulcers, or palpable purpura
- Respiratory symptoms including cough, shortness of breath, or hemoptysis
- Renal involvement with hematuria or proteinuria
- Neurological symptoms such as mononeuritis multiplex
- Eye inflammation or vision changes
Benefits of ANCA MPO and PR3 Testing
Early Detection and Accurate Diagnosis
Early identification of ANCA-associated vasculitis enables prompt intervention, potentially preventing irreversible organ damage and improving long-term outcomes.
Treatment Guidance
The specific antibody pattern (MPO vs. PR3) helps guide treatment decisions and predict disease course, allowing for personalized therapeutic approaches.
Disease Monitoring
Serial ANCA testing assists rheumatologists in monitoring disease activity, assessing treatment response, and detecting potential relapses early.
Differential Diagnosis
This test helps distinguish ANCA-associated vasculitis from other autoimmune conditions with similar presentations, ensuring appropriate management.
Understanding Your Test Results
Interpretation Guidelines
Your ANCA test results will be interpreted by our expert immunopathology team:
Positive ANCA with Specific Patterns
- C-ANCA Pattern with PR3 Positivity: Strongly associated with Granulomatosis with Polyangiitis
- P-ANCA Pattern with MPO Positivity: Typically indicates Microscopic Polyangiitis or Renal-limited vasculitis
- Atypical Patterns: May suggest other autoimmune conditions requiring further evaluation
Negative Results
A negative ANCA test doesn’t completely rule out vasculitis, as some patients may have ANCA-negative disease. Clinical correlation remains essential.
Quantitative Values
Your report will include specific antibody titers and patterns, providing valuable information about disease activity and prognosis.
Test Details and Pricing
| Test Component | Description | Price (USD) |
|---|---|---|
| ANCA Anti-Neutrophil Cytoplasmic Antibodies Positive Reflex to ANCA MPO and ANCA PR3 Test | Complete panel including ANCA IFA, MPO, and PR3 antibodies |
Discount Price: $126 Regular Price: $188 |
Sample Requirements and Processing
- Sample Type: 3 mL (2 mL minimum) serum from 1 SST tube
- Shipping: Refrigerated or frozen transport required
- Fasting: Overnight fasting preferred for optimal results
- Turnaround Time: Samples accepted Monday/Wednesday/Friday by 9:00 AM, with next-day results by 6:00 PM
Nationwide Availability
GGC DNA maintains testing facilities across the United States, ensuring convenient access to ANCA testing in major metropolitan areas including:
- New York City and surrounding regions
- Los Angeles and Southern California
- Chicago and Midwest locations
- Houston, Dallas, and Texas facilities
- Miami and Florida centers
- Seattle, Portland, and Pacific Northwest locations
Take Control of Your Autoimmune Health
Don’t let unexplained symptoms compromise your quality of life. The ANCA MPO and PR3 test provides critical insights for diagnosing and managing autoimmune vasculitis disorders. Our specialized immunopathology department, led by experienced rheumatologists, ensures accurate testing and comprehensive result interpretation.
Ready to get answers? Schedule your ANCA test today by calling our dedicated healthcare team at +1(267) 388-9828 or book your appointment online. Take the first step toward understanding your autoimmune health with confidence and clarity.
