17-Hydroxyprogesterone (17-OHP) Stimulation by ACTH Test
Understanding the 17-OHP ACTH Stimulation Test
The 17-Hydroxyprogesterone ACTH Stimulation Test is a sophisticated diagnostic procedure specifically designed to assess adrenal gland function and identify potential disorders in the cortisol synthesis pathway. This specialized test plays a critical role in evaluating how your adrenal glands respond to adrenocorticotropic hormone (ACTH) stimulation, providing essential insights into your endocrine health.
What Does This Test Measure?
This comprehensive test measures 17-hydroxyprogesterone (17-OHP) levels in your blood at two specific time points:
- Baseline measurement taken between 8-10 AM after overnight fasting
- Post-stimulation measurement taken 60 minutes after intravenous ACTH administration
The test specifically evaluates the adrenal gland’s ability to convert 17-OHP to cortisol, helping identify enzyme deficiencies that may indicate congenital adrenal hyperplasia (CAH) or other adrenal disorders.
Who Should Consider This Test?
This specialized diagnostic test is recommended for individuals experiencing symptoms that may indicate adrenal gland dysfunction:
Clinical Indications
- Infants and children with ambiguous genitalia or early puberty
- Individuals with symptoms of adrenal insufficiency
- Patients with suspected congenital adrenal hyperplasia
- Women experiencing menstrual irregularities or infertility
- Individuals with unexplained fatigue, weakness, or salt cravings
- Patients with abnormal electrolyte levels or blood pressure issues
- Those with family history of adrenal disorders
Test Procedure and Preparation
Pre-Test Instructions
- Overnight fasting is mandatory before the test
- First basal sample must be drawn between 8-10 AM
- For menstruating females, testing should occur during the first 10 days of the menstrual cycle
- Inform your healthcare provider about all current medications
Testing Process
The test involves two timed blood draws:
- Baseline blood sample collection between 8-10 AM
- Administration of 250 micrograms of synthetic ACTH (Synacthen) intravenously
- Second blood sample collection exactly 60 minutes post-ACTH administration
- Both samples are clearly marked with collection times and shipped refrigerated or frozen
Benefits of 17-OHP ACTH Stimulation Testing
- Accurate Diagnosis: Provides definitive information about adrenal function
- Early Detection: Identifies congenital adrenal hyperplasia before severe symptoms develop
- Treatment Guidance: Helps determine appropriate hormone replacement therapy
- Monitoring Capability: Assesses treatment effectiveness over time
- Comprehensive Evaluation: Offers complete adrenal function assessment
Understanding Your Test Results
Normal Response
A normal test result typically shows:
- Baseline 17-OHP levels within reference range
- Appropriate increase in 17-OHP levels post-ACTH stimulation
- No excessive elevation suggesting enzyme block
Abnormal Findings
Elevated 17-OHP levels may indicate:
- 21-hydroxylase deficiency (most common form of CAH)
- Other enzyme deficiencies in cortisol synthesis pathway
- Adrenal gland dysfunction or hyperplasia
- Need for further diagnostic evaluation
Next Steps
Your healthcare provider will interpret results in context of your clinical presentation and may recommend:
- Additional testing for confirmation
- Endocrinology consultation
- Treatment initiation if indicated
- Regular monitoring and follow-up testing
Test Pricing and Availability
| Price Type | Amount (USD) |
|---|---|
| Discount Price | $76 |
| Regular Price | $84 |
Nationwide Availability
GGC DNA provides comprehensive 17-OHP ACTH Stimulation Testing services across the United States. We have conveniently located branches in all major cities including:
- New York, NY
- Los Angeles, CA
- Chicago, IL
- Houston, TX
- Phoenix, AZ
- Philadelphia, PA
- San Antonio, TX
- San Diego, CA
- Dallas, TX
- San Jose, CA
Book Your Test Today
Take control of your endocrine health with our comprehensive 17-Hydroxyprogesterone ACTH Stimulation Test. Our experienced medical team and state-of-the-art laboratory facilities ensure accurate results and professional care throughout the testing process.
Ready to schedule your test? Contact us today:
Phone: +1(267) 388-9828
Availability: Results typically available within 1 week
Method: Radioimmunoassay for precise measurement
Don’t wait to address potential adrenal health concerns. Our specialized testing provides the clarity needed for proper diagnosis and effective treatment planning. Call now to book your appointment at any of our nationwide locations.
