DPD Gene Mutations 5FU Toxicity Detection Test
Understanding DPD Deficiency and 5-FU Chemotherapy Safety
The DPD Gene Mutations 5FU Toxicity Detection Test represents a groundbreaking advancement in personalized cancer treatment. This sophisticated pharmacogenomic analysis identifies genetic variations in the dihydropyrimidine dehydrogenase (DPD) enzyme, which plays a critical role in metabolizing 5-fluorouracil (5-FU), one of the most commonly prescribed chemotherapy drugs worldwide. Approximately 3-8% of the population carries genetic mutations that impair DPD function, putting them at significant risk for severe, and potentially fatal, toxic reactions to standard 5-FU chemotherapy doses.
What Does This Test Measure?
This comprehensive genetic analysis detects specific mutations in the DPYD gene that codes for the DPD enzyme. The test examines:
- DPD enzyme deficiency genetic markers
- Specific DPYD gene variants associated with reduced enzyme activity
- Genetic predisposition to 5-FU toxicity
- Individual metabolic capacity for fluoropyrimidine drugs
The test provides crucial information about your body’s ability to process 5-FU chemotherapy, helping your healthcare team make informed treatment decisions.
Who Should Consider This Test?
Essential Testing for Cancer Patients
This test is particularly important for individuals who:
- Are scheduled to receive 5-FU or capecitabine chemotherapy
- Have a family history of severe reactions to chemotherapy
- Are planning treatment for colorectal, breast, or gastrointestinal cancers
- Have experienced unexpected side effects from previous chemotherapy
- Want to optimize their cancer treatment safety profile
Clinical Indications and Symptoms
Patients with DPD deficiency may experience severe symptoms when exposed to 5-FU, including:
- Life-threatening neutropenia and bone marrow suppression
- Severe gastrointestinal toxicity (mucositis, diarrhea)
- Neurological complications
- Cardiotoxicity and hand-foot syndrome
- Unexpected drug accumulation and prolonged side effects
Benefits of DPD Gene Testing
Personalized Cancer Treatment Planning
By identifying DPD deficiency before chemotherapy begins, this test enables:
- Personalized dosing strategies – Adjust 5-FU doses based on genetic profile
- Reduced toxicity risk – Prevent severe adverse reactions
- Improved treatment outcomes – Maintain therapeutic efficacy while minimizing harm
- Enhanced patient safety – Avoid life-threatening complications
- Cost-effective care – Reduce hospitalizations from toxicity management
Understanding Your Test Results
Interpreting Genetic Findings
Your test results will fall into one of several categories:
- Normal DPD Activity – Standard 5-FU dosing may be appropriate
- Intermediate DPD Deficiency – Dose reduction may be recommended
- Severe DPD Deficiency – Alternative treatment options should be considered
- Carrier Status – May influence family planning considerations
It’s essential to discuss your results with your oncologist and genetic counselor to develop the most appropriate treatment plan based on your genetic profile.
Test Information and Pricing
| Test Details | Information |
|---|---|
| Test Name | DPD Gene Mutations 5FU Toxicity Detection Test |
| Regular Price | $274 USD |
| Discount Price | $246 USD |
| Turnaround Time | 12-15 working days |
| Sample Type | 4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube |
| Shipping Instructions | Ship refrigerated. DO NOT FREEZE |
| Required Forms | Duly filled Genomics Clinical Information Requisition Form (Form 20) |
| Testing Method | PCR (Polymerase Chain Reaction) |
| Department | Molecular Diagnostics |
Convenient Testing Locations Across the USA
GGC DNA has testing facilities conveniently located throughout the United States, serving patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many more. Our nationwide network ensures accessible, reliable genetic testing services for patients across the country.
Take Control of Your Cancer Treatment Safety
Don’t leave your chemotherapy safety to chance. The DPD Gene Mutations 5FU Toxicity Detection Test provides essential information that can significantly impact your cancer treatment journey. By understanding your genetic predisposition to 5-FU toxicity, you and your healthcare team can make informed decisions that prioritize your safety and treatment success.
Ready to schedule your test? Call our dedicated patient care team at +1(267) 388-9828 or book your appointment online today. Take the first step toward personalized, safer cancer treatment with GGC DNA’s comprehensive pharmacogenomic testing services.
