PROK2 Gene Kallmann Syndrome Type 4 NGS Genetic DNA Test
Comprehensive Genetic Testing for Hormonal Development Disorders
The PROK2 Gene Kallmann Syndrome Type 4 NGS Genetic DNA Test represents a breakthrough in genetic diagnostics for individuals experiencing delayed puberty and reproductive health challenges. This advanced Next-Generation Sequencing (NGS) test specifically targets mutations in the PROK2 gene, which plays a crucial role in the development and function of the hypothalamic-pituitary-gonadal axis – the master control system for reproductive hormone production.
What Does This Test Measure and Detect?
This sophisticated genetic analysis detects specific mutations and variants in the PROK2 gene that are directly associated with Kallmann Syndrome Type 4. The test examines:
- Point mutations, deletions, and insertions in the PROK2 gene coding regions
- Genetic variants affecting prokineticin-2 protein function
- Mutations disrupting normal GnRH neuron migration during embryonic development
- Genetic abnormalities that impair olfactory bulb formation and function
Who Should Consider This Test?
This genetic test is recommended for individuals presenting with the following symptoms or clinical indications:
- Delayed Puberty: Absence of pubertal development by age 14 in boys or 13 in girls
- Hypogonadotropic Hypogonadism: Low levels of sex hormones with normal pituitary anatomy
- Anosmia or Hyposmia: Complete or partial loss of sense of smell
- Family History: Relatives diagnosed with Kallmann Syndrome or congenital hypogonadism
- Reproductive Issues: Infertility or menstrual irregularities without clear cause
- Associated Features: Cleft lip/palate, hearing loss, or renal abnormalities
Significant Benefits of Genetic Testing
Undergoing the PROK2 Gene Kallmann Syndrome Type 4 test provides numerous advantages for patients and healthcare providers:
- Accurate Diagnosis: Confirms or rules out genetic causes of delayed puberty
- Personalized Treatment: Enables targeted hormone replacement therapy
- Family Planning: Provides genetic counseling information for future generations
- Early Intervention: Allows for timely treatment to prevent complications
- Comprehensive Understanding: Helps patients understand the biological basis of their condition
- Improved Outcomes: Facilitates better management of associated health issues
Understanding Your Test Results
Your genetic test results will be carefully interpreted by our team of certified genetic counselors and medical geneticists. Results typically fall into one of these categories:
- Positive Result: Identifies a pathogenic mutation in the PROK2 gene, confirming Kallmann Syndrome Type 4 diagnosis
- Negative Result: No mutations detected in the PROK2 gene, suggesting other causes for symptoms
- Variant of Uncertain Significance: Identifies genetic changes with unclear clinical implications requiring further evaluation
- Carrier Status: Identifies individuals who carry one copy of a mutated gene but may not show symptoms
Our genetic counseling team will provide comprehensive guidance on what your results mean for your health, treatment options, and family planning considerations.
Test Pricing and Details
| Test Component | Details |
|---|---|
| Test Name | PROK2 Gene Kallmann Syndrome Type 4 NGS Genetic DNA Test |
| Discount Price | $500 USD |
| Regular Price | $700 USD |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type | Blood, Extracted DNA, or One Drop Blood on FTA Card |
| Specialty | Pediatrics, Genetics |
| Method | NGS Technology |
| Disease Type | Dysmorphology, Endocrine Disorders |
Pre-Test Requirements
Before undergoing testing, patients should provide:
- Complete clinical history including pubertal development timeline
- Documentation of olfactory function assessment
- Family medical history with emphasis on reproductive and endocrine disorders
- Participation in genetic counseling session to create detailed pedigree chart
- Informed consent for genetic testing and potential implications
Nationwide Testing Availability
We have conveniently located branches across the United States, making genetic testing accessible to patients in all major metropolitan areas including New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, San Antonio, San Diego, Dallas, San Jose, and many other cities. Our state-of-the-art facilities ensure consistent, high-quality testing standards nationwide.
Take the Next Step Toward Understanding Your Health
Don’t let uncertainty about your reproductive health or delayed development continue unanswered. The PROK2 Gene Kallmann Syndrome Type 4 NGS Genetic DNA Test provides the clarity needed for proper diagnosis and effective treatment planning. Our team of genetic specialists is ready to guide you through the testing process and help you understand your results.
Call or WhatsApp us today at +1(267) 388-9828 to schedule your genetic counseling session and book your test. Take control of your health journey with definitive genetic answers.
