DSPP Gene Deafness Autosomal Dominant Type 39 with Dentinogenesis Imperfecta Type 1 NGS Genetic DNA Test
Comprehensive Genetic Analysis for Hearing and Dental Health
The DSPP Gene Deafness Autosomal Dominant Type 39 with Dentinogenesis Imperfecta Type 1 NGS Genetic DNA Test represents a cutting-edge diagnostic approach for identifying genetic mutations responsible for combined hearing loss and dental abnormalities. This specialized test utilizes next-generation sequencing technology to analyze the DSPP (Dentin Sialophosphoprotein) gene, which plays a critical role in both auditory function and dental development.
What This Test Measures and Detects
This comprehensive genetic test specifically targets mutations in the DSPP gene located on chromosome 4q21.3. The test identifies:
- Pathogenic variants associated with autosomal dominant nonsyndromic hearing loss type 39 (DFNA39)
- Genetic mutations causing dentinogenesis imperfecta type 1 (DGI-I)
- Single nucleotide polymorphisms (SNPs) and copy number variations (CNVs)
- Frameshift, missense, and nonsense mutations affecting protein function
- Inheritance patterns and carrier status information
Who Should Consider This Genetic Test
This test is particularly recommended for individuals experiencing:
- Progressive sensorineural hearing loss beginning in childhood or early adulthood
- Family history of hereditary hearing impairment
- Dental abnormalities including translucent or discolored teeth
- Increased tooth fragility and susceptibility to fracture
- Abnormal dentin formation affecting both primary and permanent teeth
- Unexplained hearing loss combined with dental enamel defects
- Planning for family with known genetic history of DFNA39 or DGI-I
Key Benefits of DSPP Genetic Testing
Undergoing this comprehensive genetic analysis provides numerous advantages:
- Early Diagnosis: Enables proactive management of hearing and dental conditions before significant progression occurs
- Personalized Treatment: Guides appropriate hearing aid selection, cochlear implant candidacy, and dental restoration planning
- Genetic Counseling: Provides accurate recurrence risk assessment for family planning decisions
- Differential Diagnosis: Helps distinguish between various forms of hereditary hearing loss and dental disorders
- Preventive Care: Facilitates early intervention strategies to preserve remaining hearing and dental function
Understanding Your Test Results
Your genetic test results will be carefully interpreted by our team of certified genetic counselors and medical geneticists:
- Positive Result: Indicates the presence of a pathogenic DSPP gene mutation, confirming the diagnosis and enabling targeted management
- Negative Result: Suggests that DSPP gene mutations were not detected, though other genetic or environmental factors may still be involved
- Variant of Uncertain Significance (VUS): Identifies genetic changes whose clinical significance requires further investigation
- Carrier Status: Determines if you carry one copy of a mutated gene that could be passed to offspring
Test Pricing Information
| Test Component | Price (USD) |
|---|---|
| Discount Price | $500 |
| Regular Price | $700 |
Nationwide Testing Availability
We have conveniently located branches across the United States, including major metropolitan areas such as New York, Los Angeles, Chicago, Houston, Phoenix, Philadelphia, and many other cities. Our state-of-the-art genetic testing facilities ensure consistent, high-quality results regardless of your location.
Take Control of Your Genetic Health Today
Understanding your genetic predisposition to hearing loss and dental disorders can significantly impact your quality of life and treatment outcomes. Our comprehensive DSPP gene testing provides the clarity needed to make informed healthcare decisions. Don’t wait to uncover the genetic factors affecting your hearing and dental health.
Book your DSPP Gene Deafness Autosomal Dominant Type 39 with Dentinogenesis Imperfecta Type 1 NGS Genetic DNA Test today by calling our genetic specialists at +1(267) 388-9828 or schedule your appointment online. Take the first step toward personalized genetic healthcare and proactive management of your auditory and dental wellbeing.
